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Cardiovascular Function of Modern Pigs Does not Comply with Allometric Scaling Laws

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van Essen, Gerard J., te Lintel Hekkert, Maaike, Sorop, Oana, Heinonen, Ilkka, van der Velden, Jolanda, Merkus, Daphne, Duncker, Dirk J.·2018·Scientific Reports
DOI 10.1038/s41598-017-18775-zPMC PMC5768797
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Abstract

Growing concerns have been expressed regarding cardiovascular performance in modern farm pigs, which has been proposed as a critical factor contributing to the reduced adaptability of modern pigs to stress. Here we tested the hypothesis that cardiac dimensions and pump function in modern heavy farm pigs are disproportionally low for their body weight, and investigated potential underlying mechanisms. The results from the present study indeed demonstrate disproportionally low values for stroke volume and cardiac output in pigs with bodyweights over 150 kg. Importantly, these low values were not the result of impaired left ventricular (LV) systolic contractile function, but were due to a disproportionally small LV end-diastolic volume. The latter was associated with changes in determinants of LV passive stiffness, including (i) an increase in LV myocardial collagen, (ii) a shift from the compliant N2BA titin isoform towards the stiff N2B, and (iii) a marked elevation of aortic blood pressure. Taken together, these results demonstrate reduced pumping capacity of the hearts of heavy modern pigs, due to structural abnormalities in the LV myocardium.

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Metadata

Authors
van Essen, G. J., te Lintel Hekkert, M., Sorop, O., Heinonen, I., van der Velden, J., Merkus, D., & Duncker, D. J.
Affiliations
  • Erasmus MC (NL)
  • University of Turku (FI)
  • Netherlands Heart Institute (NL)
Corresponding author
Duncker, Dirk J.
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2018-01-15
Volume
8
Issue
1
Pages
792-792
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-017-18775-z
PMC
PMC5768797
OpenAlex
W2783442741
Cited by
41
References
4
Citations by year
2025: 6 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 3
FWCI
2.84
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, cc-by)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
  • UTUPub (University of Turku) (submittedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
  • RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders
  • Foundation for Cardiovascular Research
  • European Commission (FP7-Health- 2010, 261409)
  • Sydäntutkimussäätiö
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
farm pigs, cardiovascular function, allometric scaling, stroke volume, cardiac output, left ventricular end-diastolic volume, myocardial collagen, titin isoforms, aortic pressure, heavy pigs, stress adaptability, cardiac pump function
MeSH terms
Animals, Blood Pressure, Body Weight, Collagen, Heart Ventricles, Myocardium, Swine, Ventricular Function, Left, Protein Isoforms, Connectin

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