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Cited by 71Nerve injury and regenerationComputational Drug Discovery MethodsSpinal Cord Injury Research

Neuroprotective Drug for Nerve Trauma Revealed Using Artificial Intelligence

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Romeo-Guitart, David, Forés, Joaquim, Herrando-Grabulosa, Mireia, Valls, Raquel, Leiva-Rodríguez, Tatiana, Galea, Elena, González-Pérez, Francisco, Navarro, Xavier +5 more·2018·Scientific Reports
DOI 10.1038/s41598-018-19767-3PMC PMC5790005
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Abstract

Here we used a systems biology approach and artificial intelligence to identify a neuroprotective agent for the treatment of peripheral nerve root avulsion. Based on accumulated knowledge of the neurodegenerative and neuroprotective processes that occur in motoneurons after root avulsion, we built up protein networks and converted them into mathematical models. Unbiased proteomic data from our preclinical models were used for machine learning algorithms and for restrictions to be imposed on mathematical solutions. Solutions allowed us to identify combinations of repurposed drugs as potential neuroprotective agents and we validated them in our preclinical models. The best one, NeuroHeal, neuroprotected motoneurons, exerted anti-inflammatory properties and promoted functional locomotor recovery. NeuroHeal endorsed the activation of Sirtuin 1, which was essential for its neuroprotective effect. These results support the value of network-centric approaches for drug discovery and demonstrate the efficacy of NeuroHeal as adjuvant treatment with surgical repair for nervous system trauma.

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  • Molecular data (for example, -omics) can be transformed into mathematical maps by artificial intelligence, thereby providing quantitative representations of the otherwise-vague notion of phenotypes.

    “Currently, molecular data (for example, -omics) can be transformed into mathematical maps by artificial intelligence118, thereby providing quantitative representations of the otherwise-vague notion of phenotypes.”

    From Reactive astrocyte nomenclature, definitions, and future directions (2021) · cites this paper as [118]

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Authors
Romeo-Guitart, D., Forés, J., Herrando-Grabulosa, M., Valls, R., Leiva-Rodríguez, T., Galea, E., González-Pérez, F., Navarro, X., Petegnief, V., Bosch, A., Coma, M., Mas, J. M., & Casas, C.
Affiliations
  • Universitat Autònoma de Barcelona (ES)
  • Anaxomics (Spain) (ES)
  • Institució Catalana de Recerca i Estudis Avançats (ES)
Corresponding author
Casas, Caty
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2018-01-30
Volume
8
Issue
1
Pages
1879-1879
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-018-19767-3
PMC
PMC5790005
OpenAlex
W2805994895
Cited by
71
References
69
Citations by year
2026: 5 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 8 · 2021: 19 · 2020: 13 · 2019: 8 · 2018: 2
FWCI
4.78
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Fundació la Marató de TV3
  • European Commission (306240)
  • Ministerio de Economía y Competitividad (#SAF 2014-59701, 2014-59701)
  • Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
Keywords
neuroprotection, drug repurposing, motor neurons, SIRT1, protein networks, mathematical modeling, proteomics, anti-inflammatory activity, locomotor recovery, drug discovery
MeSH terms
Machine Learning, Algorithms, Animals, Artificial Intelligence, Cell Line, Female, Nerve Regeneration, Peripheral Nervous System Diseases, Radiculopathy, Spinal Cord, Spinal Nerve Roots, Wounds and Injuries, Rats, Sprague-Dawley, Neuroprotective Agents, Recovery of Function, Mice, Rats

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