The clinical importance of a cytokine network in the acute phase of sepsis
Open accessAbstract
Sepsis remains a major cause of death. Cytokines interact closely with each other and play a crucial role in the progression of sepsis. We focussed on the associations of a cytokine network with prognosis and disease severities in sepsis. This retrospective study included 31 patients with sepsis and 13 healthy controls. Blood samples were collected from patients on days 1, 2, 4, 6, 8, 11 and 15 and from healthy controls. Levels of PAI-1, IFN-α, IFN-γ, IL-1β, IL-6, IL-8, IL-12/IL-23p40, IL-17A, TNF-α, MCP-1, IL-4 and IL-10 were measured. SOFA, JAAM DIC and ISTH DIC scores were evaluated at the same times blood samples were taken. Network analysis revealed a network formed by PAI-1, IL-6, IL-8, MCP-1 and IL-10 on days 1, 2 and 4 throughout the acute phase of sepsis. There were positive correlations of each cytokine and the combined score (IL-6 + IL-8 + IL-10 + MCP-1) with the SOFA, JAAM DIC and ISTH DIC scores throughout the acute phase. A Cox proportional hazards model focussed on the acute phase showed that the above combined score was significantly related with patient prognosis, suggesting that the cytokine network of IL-6, IL-8, MCP-1 and IL-10 could play a pivotal role in the acute phase of sepsis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In septic shock, underlying dysregulated immune responses produce cytokines in response to infection.
“In septic shock, underlying dysregulated immune responses produce cytokines in response to infection [23].”
From Non-Diabetic Hypoglycemia: Evaluation and Management in Adults (2025) · cites this paper as [23]
The Introduction (page unavailable) describes pathogen-associated signals activating immune cells in sepsis and an inflammatory response driven by cytokines. The Discussion (page unavailable) also says activated immune cells produce cytokines. These passages support the proposed mechanism in sepsis, but do not establish it specifically for septic shock. (LLM, conf=0.83)
Experimental — accuracy not yet measuredThis systemic overdrive accelerates glucose utilization that may outpace the body's gluconeogenic capacity.
“This systemic overdrive accelerates glucose utilization that eventually may outpace the body's gluconeogenic capacity.”
From Non-Diabetic Hypoglycemia: Evaluation and Management in Adults (2025) · cites this paper as [23]
The Introduction and Discussion describe a systemic inflammatory response and a cytokine network in sepsis, but do not address glucose utilization or gluconeogenic capacity. Searches for those terms and for glucose metabolism and hypoglycemia found no passage in our copy supporting the claimed metabolic effect; page numbers were not available. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cytoscape: A software Environment for integrated models of biomolecular interaction networks
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888 · see citing works
The third international consensus definitions for sepsis and septic shock (Sepsis-3).
Singer, M., Deutschman, C. S., Seymour, C. W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G. R., Chiche, J.-D., Coopersmith, C. M., et al. (2016) · JAMA · doi:10.1001/jama.2016.0287 · Cited by 28,250 · see citing works
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985) · Critical Care Medicine · doi:10.1097/00003246-198510000-00009 · Cited by 15,333 · see citing works
APACHE II-A Severity of Disease Classification System
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,379 · see citing works
Bone, R. C., BALK, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1644 · Cited by 13,192 · see citing works
Chen, Y., Wang, L., Kang, Q., Zhang, X., Yu, G., Wan, X., Wang, J., & Zhu, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477308 · Cited by 10,730 · see citing works
APACHE II: a severity of disease classification system.
Knaus, W. A., Draper, E. S., Wagner, D. P., & Zimmerman, J. E. (1985) · PubMed · Cited by 6,034 · see citing works
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference
(1992) · Critical Care Medicine · doi:10.1097/00003246-199206000-00025 · Cited by 5,091 · see citing works
Surviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002255 · Cited by 3,652 · see citing works
Hematological Problems in Pediatric Intensive Care
Revel‐Vilk, S., Cox, P. N., Robitaille, N., & Blanchette, V. S. (2013) · Pediatric and adolescent medicine · doi:10.1159/000350346 · Cited by 3,526 · see citing works
Serial Evaluation of the SOFA Score to Predict Outcome in Critically Ill Patients
Ferreira, F. L. (2001) · JAMA · doi:10.1001/jama.286.14.1754 · Cited by 2,862 · see citing works
Taylor, F., Toh, C.-H., Hoots, K., Wada, H., & Levi, M. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1616068 · Cited by 2,285 · see citing works
Pierrakos, C. N., & Vincent, J. (2010) · Critical Care · doi:10.1186/cc8872 · Cited by 1,389 · see citing works
A genomic storm in critically injured humans
Xiao, W., Mindrinos, M. N., Seok, J., Cuschieri, J., Cuenca, A. G., Gao, H., Hayden, D. L., Hennessy, L. V., Moore, E. E., Minei, J. P., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20111354 · Cited by 1,226 · see citing works
Levi, M. M., & van der Poll, T. (2016) · Thrombosis Research · doi:10.1016/j.thromres.2016.11.007 · Cited by 852 · see citing works
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis
Bozza, F. A., Salluh, J. I., Japiassú, A. M., Soares, M., de Assis, E. F., Gomes, R. N., Bozza, M. T., Castro-Faria-Neto, H. C., & Bozza, P. T. (2007) · Critical Care · doi:10.1186/cc5783 · Cited by 740 · see citing works
Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View
Schulte, W., Bernhagen, J., & Bucala, R. (2013) · Mediators of Inflammation · doi:10.1155/2013/165974 · Cited by 720 · see citing works
Immunotherapeutic Implications of Il-6 Blockade for Cytokine Storm
Tanaka, T., Narazaki, M., & Kishimoto, T. (2016) · Immunotherapy · doi:10.2217/imt-2016-0020 · Cited by 708 · see citing works
Self-citationİnce, C., Mayeux, P. R., Nguyen, T. C., Gómez, H., Kellum, J. A., Ospina-Tascón, G. A., Glenn Hernández, P., Murray, P. T., & Backer, D. D. (2016) · Shock · doi:10.1097/shk.0000000000000473 · Cited by 676 · see citing works
Gando, S., Iba, T., Eguchi, Y., Ohtomo, Y., Okamoto, K., Koseki, K., Mayumi, T., Murata, A., Ikeda, T., Ishikura, H., et al. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000202209.42491.38 · Cited by 647 · see citing works
Self-citationHost–pathogen interactions in sepsis
van der Poll, T., & Opal, S. M. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70265-7 · Cited by 552 · see citing works
Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding
Iskander, K. N., Osuchowski, M. F., Stearns-Kurosawa, D. J., Kurosawa, S., Stepien, D. M., Valentine, C., & Remick, D. G. (2013) · Physiological Reviews · doi:10.1152/physrev.00037.2012 · Cited by 451 · see citing works
The late phase of sepsis is characterized by an increased microbiological burden and death rate
Otto, G. P., Soßdorf, M., Claus, R. A., Rödel, J., Menge, K., Reinhart, K., Bauer, M. W., & Riedemann, N. C. (2011) · Critical Care · doi:10.1186/cc10332 · Cited by 431 · see citing works
The Cytokine Network in Chronic Obstructive Pulmonary Disease
Barnes, P. J. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0220tr · Cited by 412 · see citing works
How Cytokine Networks Fuel Inflammation: Toward a cytokine-based disease taxonomy
Schett, G., Elewaut, D., McInnes, I. B., Dayer, J.-M., & Neurath, M. F. (2013) · Nature Medicine · doi:10.1038/nm.3260 · Cited by 406 · see citing works
Wada, H., Matsumoto, T., & Yamashita, Y. (2014) · Journal of Intensive Care · doi:10.1186/2052-0492-2-15 · Cited by 322 · see citing works
Martin, T., Cardarelli, P. M., Parry, G. C., Felts, K. A., & Cobb, R. R. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270508 · Cited by 317 · see citing works
IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways
Schraufstätter, I. U., Chung, J., & Burger, M. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.280.6.l1094 · Cited by 278 · see citing works
ODA, S., Hirasawa, H., Shiga, H., NAKANISHI, K., MATSUDA, K., & NAKAMUA, M. (2004) · Cytokine · doi:10.1016/j.cyto.2004.10.010 · Cited by 253 · see citing works
Multiplex cytokine profiling in patients with sepsis
Mera, S., Țățulescu, D., Cismaru, C. M., Bondor, C. I., Slavcovici, A., Zanc, V., Cârstina, D., & Oltean, M. (2010) · Apmis · doi:10.1111/j.1600-0463.2010.02705.x · Cited by 231 · see citing works
Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases
Amarasekara, D. S., Yu, J., & Rho, J. (2015) · Journal of Immunological Research · doi:10.1155/2015/832127 · Cited by 175 · see citing works
Andaluz‐Ojeda, D., Bobillo, F., Iglesias, V., Almansa, R., Rico, L., Gandía, F., Resino, S., Tamayo, E., de Lejarazu, R. O., & Bermejo-Martín, J. F. (2011) · Cytokine · doi:10.1016/j.cyto.2011.12.002 · Cited by 171 · see citing works
Plasma Biomarkers for Acute Respiratory Distress Syndrome
Terpstra, M. L., Aman, J., Amerongen, G. P. V. N., & Groeneveld, A. B. J. (2013) · Critical Care Medicine · doi:10.1097/01.ccm.0000435669.60811.24 · Cited by 169 · see citing works
Cytokine profile in severe gram-positive and gram-negative abdominal sepsis
Šurbatović, M., Popović, N., Vojvodić, D., Milošević, I., Acimovic, G., Stojičić, M., Veljović, M., Jevdjić, J., Djordjevic, D., & Radakovic, S. (2015) · Scientific Reports · doi:10.1038/srep11355 · Cited by 139 · see citing works
Tumour necrosis factor in infectious disease
Waters, J. P., Pober, J. S., & Bradley, J. R. (2013) · The Journal of Pathology · doi:10.1002/path.4187 · Cited by 136 · see citing works
Predictive Value of IL-8 for Sepsis and Severe Infections After Burn Injury
Kraft, R., Herndon, D. N., Finnerty, C. C., Cox, R. A., Song, J., & Jeschke, M. G. (2014) · Shock · doi:10.1097/shk.0000000000000294 · Cited by 125 · see citing works
Tissue factor expression in blood cells.
Østerud, B. (2010) · Thrombosis Research · doi:10.1016/j.thromres.2010.01.032 · Cited by 111 · see citing works
MCP-1 induces activation of MAP-kinases ERK, JNK and p38 MAPK in human endothelial cells
Werle, M., SCHMAL, U., Hanna, K., & Kreuzer, J. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00600-4 · Cited by 98 · see citing works
Levi, M. M., & van der Poll, T. (2013) · Intensive Care Medicine · doi:10.1007/s00134-013-3054-1 · Cited by 64 · see citing works
Mizobata, Y. (2017) · Journal of Intensive Care · doi:10.1186/s40560-016-0197-5 · Cited by 61 · see citing works
Chen, S., Wang, A. Y. L., Fan, H., Lo, W., Wang, C., & Sytwu, H. (2011) · Clinical and Developmental Immunology · doi:10.1155/2012/970789 · Cited by 46 · see citing works
Sousa, A. N., Raposo, F. J. A., Fonseca, S., Valente, L., Duarte, F., Gonçalves, M., Tuna, D., & Paiva, J.-A. (2015) · Disease Markers · doi:10.1155/2015/747036 · Cited by 40 · see citing works
The role of tissue factor in systemic inflammatory response syndrome
Egorina, E. M., Sovershaev, M. A., & Hansen, J. (2011) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0b013e328346ef3f · Cited by 35 · see citing works
Janssens, U., Dujardin, R., Graf, J., Lepper, W., Ortlepp, J. R., Merx, M. W., Zarse, M., Reffelmann, T., & Hanrath, P. (2001) · Critical Care · doi:10.1186/cc1292 · Cited by 29 · see citing works
Overview of Maximum Likelihood Estimation
Harrell, F. E. (2001) · Springer series in statistics · doi:10.1007/978-1-4757-3462-1_9 · Cited by 22 · see citing works
Koyama, K., & Nunomiya, S. (2017) · Journal of Intensive Care · doi:10.1186/s40560-017-0259-3 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review
Barichello, T., Generoso, J. S., Singer, M., & Dal‐Pizzol, F. (2022) · Critical Care · doi:10.1186/s13054-021-03862-5 · Cited by 471 · see citing works
Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms
Kang, S., & Kishimoto, T. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00649-0 · Cited by 382 · see citing works
Self-citationKang, S., Tanaka, T., Inoue, H., Ono, C., Hashimoto, S., Kioi, Y., Matsumoto, H., Matsuura, H., Matsubara, T., Shimizu, K., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2010229117 · Cited by 328 · see citing works
Self-citationCajander, S., Kox, M., Scicluna, B. P., Weigand, M. A., Mora, R. A., Flohé, S. B., Martín‐Loeches, I., Lachmann, G., Girardis, M., García‐Salido, A., et al. (2023) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(23)00330-2 · Cited by 238 · see citing works
Current methods to analyze lysosome morphology, positioning, motility and function
Barral, D. C., Staiano, L., Almeida, C. G., Cutler, D. F., Eden, E. R., Futter, C. E., Galione, A., Marques, A. R. A., Medina, D. L., Napolitano, G., et al. (2022) · Traffic · doi:10.1111/tra.12839 · Cited by 179 · see citing works
Shankar‐Hari, M., Calandra, T., Soares, M. P., Bauer, M. W., Wiersinga, W. J., Prescott, H. C., Knight, J. C., Baillie, J. K., Bos, L. D. J., Derde, L. P. G., et al. (2024) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(23)00468-x · Cited by 142 · see citing works
Lei, Y., Martinez, C. G., Torres-Odio, S., Bell, S. L., Birdwell, C. E., Bryant, J. D., Tong, C. W.-C., Watson, R. O., West, L. C., & West, A. P. (2021) · Science Advances · doi:10.1126/sciadv.abe7548 · Cited by 131 · see citing works
BCG vaccination–induced emergency granulopoiesis provides rapid protection from neonatal sepsis
Brook, B., Harbeson, D. J., Shannon, C. P., Cai, B., He, D. X., Ben-Othman, R., Francis, F., Huang, Y. Z., Varankovich, N. V., Liu, A. C., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax4517 · Cited by 126 · see citing works
Choi, S., Yang, J., Lee, S. Y., Kim, J., Lee, J., Kim, W. J., Lee, S., & Kim, C. (2022) · Advanced Science · doi:10.1002/advs.202202089 · Cited by 102 · see citing works
Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases
Tang, X., Ji, T.-T., Dong, J.-R., Feng, H., Chen, F.-Q., Chen, X., Zhao, H., Chen, D., & Ma, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313009 · Cited by 102 · see citing works
Anderberg, S. B., Luther, T., Berglund, M., Larsson, R. L., Rubertsson, S., Lipcsey, M., Larsson, A. O., Frithiof, R., & Hultström, M. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155389 · Cited by 87 · see citing works
Befriending the Hostile Tumor Microenvironment in CAR T-Cell Therapy
Lindo, L., Wilkinson, L., & Hay, K. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.618387 · Cited by 88 · see citing works
Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory properties
Wang, X., Zhang, Y., Kong, H., Cheng, J., Zhang, M., Sun, Z., Wang, S., Liu, J., Qu, H., & Zhao, Y. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1699810 · Cited by 79 · see citing works
Liu, G., Jiang, C., Lin, X., & Yang, Y. (2021) · Open Research (University of Surrey) · doi:10.1002/viw.20210003 · Cited by 77 · see citing works
Wang, A., Pope, S. D., Weinstein, J. S., Yu, S., Zhang, C., Booth, C. J., & Medzhitov, R. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820704116 · Cited by 67 · see citing works
Apoptotic cell therapy for cytokine storm associated with acute severe sepsis
Karbian, N., Abutbul, A., el-Amore, R., Eliaz, R., Beeri, R., Reicher, B., & Mevorach, D. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02748-8 · Cited by 63 · see citing works
Frimpong, A., Owusu, E. D. A., Amponsah, J. A., Obeng-Aboagye, E., van der Puije, W., Frempong, A. F., Kusi, K. A., & Ofori, M. F. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.901433 · Cited by 63 · see citing works
Skrypnyk, N. I., Gist, K. M., Okamura, K., Montford, J. R., You, Z.-Y., Yang, H.-C., Moldovan, R., Bodoni, E., Blaine, J., Edelstein, C., et al. (2019) · Kidney International · doi:10.1016/j.kint.2019.11.013 · Cited by 53 · see citing works
Involvement of Inflammation and Its Resolution in Disease and Therapeutics
Alfaro, S., Acuña, V., Ceriani, R., Cavieres, M. F., Oppenheimer, C. W., & Campos‐Estrada, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810719 · Cited by 63 · see citing works
The immunology of sepsis: translating new insights into clinical practice
Kox, M., Bauer, M. W., Bos, L. D. J., Bouma, H. R., Calandra, T., Calfee, C. S., Chousterman, B. G., Derde, L. P. G., Giamarellos‐Bourboulis, E. J., Gómez, H., et al. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-025-01004-6 · Cited by 68 · see citing works
Anterior pituitary function in critical illness
Téblick, A., Langouche, L., & Van den Berghe, G. (2019) · Endocrine Connections · doi:10.1530/ec-19-0318 · Cited by 52 · see citing works
Langeland, H., Damås, J. K., Mollnes, T. E., Ludviksen, J. K., Ueland, T., Michelsen, A. E., Løberg, M., Bergum, D., Nordseth, T., Skjærvold, N. K., et al. (2021) · Resuscitation · doi:10.1016/j.resuscitation.2021.11.026 · Cited by 50 · see citing works
Precision medicine in sepsis and septic shock: From omics to clinical tools
Ruiz‐Rodríguez, J. C., Plata-Menchaca, E. P., Chiscano‐Camón, L., Ruiz-Sanmartín, A., Pérez-Carrasco, M., Palmada, C., Ribas, V. J., Martínez‐Gallo, M., Hernández-González, M., González‐López, J. J., et al. (2022) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v11.i1.1 · Cited by 49 · see citing works
Dual-Enhanced Plasmonic Biosensing for Point-of-Care Sepsis Detection
Chin, L. K., Yang, J.-Y., Chousterman, B. G., Jung, S., Kim, D.-G., Kim, D., Lee, S., Castro, C. M., Weissleder, R., Park, S., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c10371 · Cited by 49 · see citing works
Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis
Garzón-Tituaña, M., Sierra-Monzón, J. L., Comas, L., Santiago, L., Ushakova, T. K., Uranga-Murillo, I., Ramírez-Labrada, A., Tapia, E., Morte-Romea, E., Algarate, S., et al. (2021) · Theranostics · doi:10.7150/thno.49288 · Cited by 49 · see citing works
The Multifaceted Function of Granzymes in Sepsis: Some Facts and a Lot to Discover
Garzón-Tituaña, M., Arias, M. A., Sierra-Monzón, J. L., Morte-Romea, E., Santiago, L., Ramírez-Labrada, A., Martínez‐Lostao, L., Paño‐Pardo, J. R., Gálvez, E. M., & Pardo, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01054 · Cited by 46 · see citing works
Liu, P., Xiao, Z., Yan, H., Lu, X., Zhang, X., Luo, L., Long, C., & Zhu, Y. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106685 · Cited by 43 · see citing works
Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function
Li, C., Ture, S. K., Nieves-López, B., Blick-Nitko, S. K., Maurya, P., Livada, A. C., Stahl, T. J., Kim, M., Pietropaoli, A. P., & Morrell, C. N. (2024) · Circulation Research · doi:10.1161/circresaha.123.323662 · Cited by 44 · see citing works
Varga, N.-I., Bagiu, I. C., Vulcănescu, D. D., Lăzureanu, V. E., Turaiche, M., Roșca, O., Bota, A. V., & Horhat, F. G. (2025) · Biomolecules · doi:10.3390/biom15030407 · Cited by 40 · see citing works
Photoacoustic monitoring of angiogenesis predicts response to therapy in healing wounds
Mantri, Y., Tsujimoto, J., Donovan, B., Fernandes, C. C., Garimella, P. S., Penny, W. F., Anderson, C. A., & Jokerst, J. V. (2022) · Wound Repair and Regeneration · doi:10.1111/wrr.12992 · Cited by 39 · see citing works
Interleukin-18 serum levels in sepsis: Correlation with disease severity and inflammatory markers
Mierzchała-Pasierb, M., Krzystek‐Korpacka, M., Leśnik, P., Adamik, B., Płaczkowska, S., Serek, P., Gamian, A., & Lipińska-Gediga, M. (2019) · Cytokine · doi:10.1016/j.cyto.2019.04.003 · Cited by 38 · see citing works
Kohoutková, M. H., Lázničková, P., Bendíčková, K., Zuani, M. D., Andrejčinová, I., Tomášková, V., Suk, P., Šrámek, V., Helán, M., & Frič, J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15791 · Cited by 36 · see citing works
Zou, Z.-Y., Huang, J.-J., Luan, Y., Yang, Z.-J., Zhou, Z.-P., Zhang, J., Yao, Y.-M., & Wu, M. T. (2022) · Burns & Trauma · doi:10.1093/burnst/tkac029 · Cited by 34 · see citing works
Deciphering the balance of IL-6/IL-10 cytokines in severe to critical COVID-19 patients
Azaiz, M. B., Jemaa, A. B., Sellami, W., Romdhani, C., Ouslati, R., Gharsallah, H., Ghazouani, E., & Ferjani, M. (2022) · Immunobiology · doi:10.1016/j.imbio.2022.152236 · Cited by 35 · see citing works
Ebihara, T., Matsumoto, H., Matsubara, T., Matsuura, H., Hirose, T., Shimizu, K., Ogura, H., Kang, S., Tanaka, T., & Shimazu, T. (2021) · Shock · doi:10.1097/shk.0000000000001756 · Cited by 31 · see citing works
Self-citationHedetoft, M., Garred, P., Madsen, M. B., & Hyldegaard, O. (2021) · Physiological Reports · doi:10.14814/phy2.14757 · Cited by 31 · see citing works
Modeling Tumor Disease and Sepsis by Networks of Adaptively Coupled Phase Oscillators
Sawicki, J., Berner, R., Löser, T., & Schöll, E. (2022) · Frontiers in Network Physiology · doi:10.3389/fnetp.2021.730385 · Cited by 31 · see citing works
LaFavers, K. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031702 · Cited by 28 · see citing works
Metwally, H., Elbrashy, M. M., Ozawa, T., Okuyama, K., White, J. T., Tulyeu, J., Søndergaard, J. N., Wing, J. B., Muratsu, A., Matsumoto, H., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2402226121 · Cited by 26 · see citing works
Self-citationExosomes as novel biomarkers in sepsis and sepsis related organ failure
Yuan, Y., Xiao, Y., Zhao, J., Zhang, L., Li, M., Luo, L., Jia, Y., Wang, K., Chen, Y., Wang, P., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05817-0 · Cited by 27 · see citing works
Nguyen, T. H., Turek, I., Meehan-Andrews, T., Zacharias, A., & Irving, H. R. (2020) · PLoS ONE · doi:10.1371/journal.pone.0244570 · Cited by 27 · see citing works
Strampe, J., Asogun, D., Speranza, E. E., Pahlmann, M., Soucy, A., Bockholt, S., Pallasch, E., Becker‐Ziaja, B., Duraffour, S., Bhadelia, N., et al. (2021) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30737-4 · Cited by 27 · see citing works
Heparan sulfates and heparan sulfate binding proteins in sepsis
Liao, Y.-E., Liu, J., & Arnold, K. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1146685 · Cited by 26 · see citing works
Immune gene expression networks in sepsis: A network biology approach
Kim, K. S., Jekarl, D. W., Yoo, J., Lee, S., Kim, M., & Kim, Y. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247669 · Cited by 26 · see citing works
Nguyen, T. H., Turek, I., Meehan-Andrews, T., Zacharias, A., & Irving, H. R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263968 · Cited by 27 · see citing works
Early Diagnosis of Sepsis: The Role of Biomarkers and Rapid Microbiological Tests
Plata-Menchaca, E. P., Ruiz‐Rodríguez, J. C., & Ferrer, R. (2024) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0044-1787270 · Cited by 25 · see citing works
Protective Effects of Idebenone against Sepsis Induced Acute Lung Damage
Akpınar, E., Kutlu, Z., Köse, D., Aydın, P., Tavacı, T., Bayraktutan, Z., Yüksel, T. N., Yıldırım, S., Eser, G., & Dinçer, B. (2021) · Journal of Investigative Surgery · doi:10.1080/08941939.2021.1898063 · Cited by 24 · see citing works
Marashian, S. M., Hashemian, M., Pourabdollah, M., Nasseri, M., Mahmoudian, S., Reinhart, F., & Eslaminejad, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.929837 · Cited by 24 · see citing works
A cytokine/PTX3 prognostic index as a predictor of mortality in sepsis
Davoudian, S., Piovani, D., Desai, A., Mapelli, S. N., Leone, R., Sironi, M., Valentino, S., Silva-Gomes, R., Stravalaci, M., Asgari, F., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.979232 · Cited by 24 · see citing works
Pischke, S. E., Hestenes, S., Johansen, H. T., Fure, H., Bugge, J. F., Espinoza, A. W., Skulstad, H., Edvardsen, T., Fosse, E. T., Mollnes, T. E., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218624 · Cited by 23 · see citing works
Signaling networks in inflammatory pathways and risk for suicidal behavior
Rengasamy, M., Zhong, Y., Marsland, A., Chen, K., Douaihy, A., Brent, D., & Melhem, N. M. (2020) · Brain, Behavior, & Immunity - Health · doi:10.1016/j.bbih.2020.100122 · Cited by 21 · see citing works
Evolving Paradigms in Sepsis Management: A Narrative Review
Kim, M., Choi, E.-J., & Choi, E.-J. (2024) · Cells · doi:10.3390/cells13141172 · Cited by 23 · see citing works
Localized cytokine responses to total knee arthroplasty and total knee revision complications
Prince, N., Penatzer, J. A., Dietz, M. J., & Boyd, J. W. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02510-w · Cited by 22 · see citing works
Serial Change of Endotoxin Tolerance in a Polymicrobial Sepsis Model
Lee, M. J., Bae, J., Lee, J. H., Park, Y. J., Lee, H. A. R., Mun, S., Kim, Y.-S., Yune, C. J., Chung, T. N., & Kim, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126581 · Cited by 19 · see citing works
Kumari, T., Verma, D. P., Kuldeep, J., Dhanabal, V. B., Verma, N. K., Sahai, R., Tripathi, A. K., Saroj, J., Ali, M., Mitra, K., et al. (2022) · ACS Chemical Biology · doi:10.1021/acschembio.2c00569 · Cited by 19 · see citing works
The mechanistic basis linking cytokine storm to thrombosis in COVID-19
Wolf, A. J., Khimani, F., Yoon, B., Gerhart, C. R. B., Endsley, D., Ray, A., Yango, A. F., Flynn, S. D., Lip, G. Y. H., Gonzalez, S. A., et al. (2022) · Thrombosis Update · doi:10.1016/j.tru.2022.100110 · Cited by 18 · see citing works
Rosenthal, L., Leithner, C., Tong, G., Streitberger, K. J., Krech, J., Storm, C., & Schmitt, K. R. L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226005 · Cited by 18 · see citing works
Bender, D. E., Schaettler, M. O., Sheehan, K. C. F., Johanns, T. M., & Dunn, G. P. (2021) · Biomarker Insights · doi:10.1177/11772719211006666 · Cited by 17 · see citing works
Imaging approaches for monitoring three‐dimensional cell and tissue culture systems
Hilzenrat, G., Gill, E. T., & McArthur, S. L. (2022) · Journal of Biophotonics · doi:10.1002/jbio.202100380 · Cited by 17 · see citing works
Stavropoulou, E., Ieronymaki, E., Dimitroulia, E., Constantinidis, T. C., Vrioni, G., Tsatsanis, C., & Tsakris, A. (2022) · Microorganisms · doi:10.3390/microorganisms10122374 · Cited by 17 · see citing works
Kang, S., Onishi, S., Ling, Z., Inoue, H., Zhang, Y., Chang, H., Zhao, H., Wang, T., Okuzaki, D., Matsuura, H., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315898120 · Cited by 17 · see citing works
Self-citationComprehensive Analysis of the Safety Profile of a Single-Stranded RNA Nano-Structure Adjuvant
Park, H.-J., Ko, H. L., Won, D., Hwang, D., Shin, Y., Kwak, H., Kim, H., Yun, J.-W., & Nam, J. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11090464 · Cited by 17 · see citing works
Immune Response Resetting as a Novel Strategy to Overcome SARS-CoV-2–Induced Cytokine Storm
Nowill, A. E., & de Campos-Lima, P. O. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000892 · Cited by 17 · see citing works
Blood purification in sepsis and COVID-19: what´s new in cytokine and endotoxin hemoadsorption
Ruiz‐Rodríguez, J. C., Plata-Menchaca, E. P., Chiscano‐Camón, L., Ruiz‐Sanmartín, A., & Ferrer, R. (2022) · Journal of Anesthesia Analgesia and Critical Care · doi:10.1186/s44158-022-00043-w · Cited by 16 · see citing works
HSP-Target of Therapeutic Agents in Sepsis Treatment
Vulczak, A., Catalão, C. H. R., de Freitas, L. A. P., & Rocha, M. J. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174255 · Cited by 16 · see citing works
C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera
de França, F. S., Villas-Boas, I. M., Cogliati, B., Woodruff, T. M., Reis, E. D. S., Lambris, J. D., & Tambourgi, D. V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.652242 · Cited by 16 · see citing works
Ebihara, T., Matsubara, T., Togami, Y., Matsumoto, H., Tachino, J., Matsuura, H., Kojima, T., Sugihara, F., Seno, S., Okuzaki, D., et al. (2022) · Journal of Clinical Immunology · doi:10.1007/s10875-022-01386-3 · Cited by 15 · see citing works
Self-citationMohr, E. T. B., Nascimento, M. V. P. D. S., da Rosa, J. S., Vieira, G. N., Kretzer, I. F., Sandjo, L. P., & Dalmarco, E. M. (2019) · Mediators of Inflammation · doi:10.1155/2019/6474168 · Cited by 17 · see citing works
Epigenetic scores for the circulating proteome as tools for disease predictionPreprint
Gadd, D. A., Hillary, R. F., McCartney, D. L., Zaghlool, S. B., Stevenson, A. J., Nangle, C., Campbell, A., Flaig, R., Harris, S. E., Walker, R. M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.01.404681 · Cited by 15 · see citing works
ELAVL1 promotes LPS-induced endothelial cells injury through modulation of cytokine storm
Zhou, C., Luo, Y., Huang, Z., Dong, F., Lin, J., Luo, L., Li, X., Cai, C., & Wu, W. (2023) · Immunobiology · doi:10.1016/j.imbio.2023.152412 · Cited by 15 · see citing works
Leaking chemokines confuse neutrophils
Márki, A., & Ley, K. F. (2020) · Journal of Clinical Investigation · doi:10.1172/jci136259 · Cited by 15 · see citing works
de França, F. S., Gabrili, J. J. M., Mathieu, L., Burgher, F., Blomet, J., & Tambourgi, D. V. (2021) · Archives of Toxicology · doi:10.1007/s00204-020-02959-0 · Cited by 14 · see citing works
Paul, B. R., De, U. K., Sarkar, V. K., Gandhar, J. S., Patra, M. K., Agrawal, R. K., Singh, M. K., Soni, S., & Chethan, G. E. (2023) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2023.110598 · Cited by 14 · see citing works
Skeletal Muscle Myofibers Directly Contribute to LPS-Induced Systemic Inflammatory Tone
Bivona, J. J., Mank, M. M., Stapleton, R. D., Files, D. C., Toth, M. J., & Poynter, M. E. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.917917 · Cited by 13 · see citing works
Gouveia, G. A., Saateh, A., Świetlikowska, A., Scarpellini, C., Tsang, E., Altug, H., Merkx, M., Dillen, A., Leirs, K., Spasić, D., et al. (2024) · ACS Sensors · doi:10.1021/acssensors.4c02569 · Cited by 13 · see citing works
Villegas-Novoa, C., Gallegos‐Infante, J. A., González‐Laredo, R. F., García-Carrancá, A. M., Herrera-Rocha, K. M., Jacobo-Karam, J. S., Moreno‐Jiménez, M. R., & Rocha‐Guzmán, N. E. (2019) · Medicinal Chemistry Research · doi:10.1007/s00044-019-02448-9 · Cited by 13 · see citing works
Choi, S. J., Dwyer, C. N., Rapkin, L. M., Cormier, M., Hindmarch, C. C. T., Nesbitt, K., Michels, A., Hopman, W. M., Swystun, L. L., & Lillicrap, D. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2022.11.022 · Cited by 12 · see citing works
Tan, K. K., Minejima, E., Lou, M., Mack, W. J., Nieberg, P., & Wong‐Beringer, A. (2021) · BMC Infectious Diseases · doi:10.1186/s12879-021-06010-0 · Cited by 12 · see citing works
Wadehn, H., Raluy, L. P., Kolman, J. P., Dücker, C. M., Trochimiuk, M., Appl, B., Boettcher, M., Reinshagen, K., & Trah, J. (2021) · Central European Journal of Immunology · doi:10.5114/ceji.2021.111493 · Cited by 12 · see citing works
Clère-Jehl, R., Merdji, H., Kassem, M., Macquin, C., de Cauwer, A., Sibony, A., Kurihara, K., Minniti, L., Fayçal, C. A., Bahram, S., et al. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0401oc · Cited by 12 · see citing works
Metabolic reprogramming tailors T cell immunity in sepsis
Xian, D., Chen, F., Liu, B., & Wang, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1679493 · Cited by 11 · see citing works
Stervbo, U., Bajda, S., Wehler, P., Rohn, B., Streichhahn, M., Temizsoy, S., Kohut, E., Roch, T., Viebahn, R., Westhoff, T. H., et al. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155044 · Cited by 11 · see citing works
Zheng, Q., Xu, D., Wang, Q., Liu, W., Liu, W., & Wang, J. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.107246 · Cited by 11 · see citing works
Resistin forms a network with inflammatory cytokines and is associated with prognosis in major burns
Onishi, S., Matsuura, H., Osuka, A., Matsumoto, H., Ebihara, T., & Ogura, H. (2021) · Burns · doi:10.1016/j.burns.2021.10.009 · Cited by 11 · see citing works
Self-citationHydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice
Matsuura, H., Matsumoto, H., Okuzaki, D., Shimizu, K., Ogura, H., Ebihara, T., Matsubara, T., Hirano, S., & Shimazu, T. (2021) · Journal of Surgical Research · doi:10.1016/j.jss.2021.01.022 · Cited by 11 · see citing works
Self-citationNon-Diabetic Hypoglycemia: Evaluation and Management in Adults
Looi, E., & Lawler, H. M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14134393 · Cited by 10 · see citing works
“In septic shock, underlying dysregulated immune responses produce cytokines in response to infection [23].”
Tian, Z., Zhao, C., Huang, T., Yu, L., Sun, Y., Tao, Y., Cao, Y., Du, R., Lin, W., & Zeng, J. (2024) · Pharmaceuticals · doi:10.3390/ph17070817 · Cited by 10 · see citing works
Tavacı, T., Halıcı, Z., Çadırcı, E., Özkaraca, M., & Kaşalı, K. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01649-6 · Cited by 10 · see citing works
Relouw, F. J. A., Kox, M., Taal, H. R., Koch, B. C. P., Prins, M. W. J., & van Riel, N. A. W. (2024) · npj Systems Biology and Applications · doi:10.1038/s41540-024-00473-y · Cited by 13 · see citing works
Bai, R., & Guo, J. (2025) · Biology Direct · doi:10.1186/s13062-025-00669-0 · Cited by 9 · see citing works
Alzubaidi, A. N., Karabayir, İ., Akbilgiç, O., & Langham, M. R. (2020) · Annals of Surgery · doi:10.1097/sla.0000000000004234 · Cited by 9 · see citing works
Wu, D., Wang, L., Hong, D., Zheng, C., Zeng, Y., Ma, H., Lin, J., Chen, J., & Zheng, R. (2022) · Clinical Immunology · doi:10.1016/j.clim.2021.108915 · Cited by 9 · see citing works
Cardiac‐gated spectroscopic photoacoustic imaging for ablation‐induced necrotic lesion visualization
Gao, S., Ashikaga, H., Suzuki, M., Mansi, T., Kim, Y., Ghesu, F., Kang, J., Boctor, E. M., Halperin, H. R., & Zhang, H. K. (2024) · Journal of Biophotonics · doi:10.1002/jbio.202400126 · Cited by 8 · see citing works
Rodrigues, C. S., Kapadia, F. N., Shetty, A., Lambe, G., Mansukhani, D., & Khodaiji, S. (2021) · Indian Journal of Critical Care Medicine · doi:10.5005/jp-journals-10071-24079 · Cited by 8 · see citing works
Ruiz‐Rodríguez, J. C., Chiscano‐Camón, L., Ruiz‐Sanmartín, A., Costa-Allué, N., Bajaña, I., Nicolás-Morales, P., Bastidas, J., Cantenys-Molina, S., Hernández-González, M., Larrosa, N., et al. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15031057 · Cited by 7 · see citing works
Are corticosteroids in intensive care immunosuppressive? Reflections and hypotheses
Braïk, R. (2025) · Anaesthesia Critical Care & Pain Medicine · doi:10.1016/j.accpm.2025.101492 · Cited by 7 · see citing works
Yan, Y., Jin, P., Lu, J., Cheng, D., Xu, J., Yuan, J., Yu, Z., & Hu, Y. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-21-2171 · Cited by 7 · see citing works
Aging exacerbates cardiac dysfunction and mortality in sepsis through enhancing TLR2 activity
Zhai, Y., Yao, Q., The, E., Ao, L., Fullerton, D. A., & Meng, X. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1293866 · Cited by 7 · see citing works
Schmoch, T., Gallenstein, N., Peters, V., Bartošová, M., Uhle, F., Kummer, L., Mair, A., Krauser, U., Feißt, M., Nawroth, P. P., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105644 · Cited by 6 · see citing works
You, S., Kweon, O. J., Jung, S., Baek, M. S., & Kim, W. (2023) · Acute and Critical Care · doi:10.4266/acc.2023.00507 · Cited by 6 · see citing works
- Authors
- Matsumoto, H., Ogura, H., Shimizu, K., Ikeda, M., Hirose, T., Matsuura, H., Kang, S., Takahashi, K., Tanaka, T., & Shimazu, T.
- Affiliations
- The University of Osaka (JP)
- Osaka City University (JP)
- Corresponding author
- Matsumoto, Hisatake
- ORCID
- Venue
- Scientific Reports
- Published
- 2018-09-18
- Volume
- 8
- Issue
- 1
- Pages
- 13995-13995
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6143513
- OpenAlex
- W2891533504
- Cited by
- 193
- References
- 47
- Citations by year
- 2026: 14 · 2025: 30 · 2024: 20 · 2023: 18 · 2022: 36 · 2021: 34 · 2020: 27 · 2019: 14
- FWCI
- 14.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- A Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology in Japan.
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- sepsis, cytokine network, prognostic factors, interleukin-6, interleukin-8, MCP-1, IL-10, plasminogen activator inhibitor-1, SOFA score, disseminated intravascular coagulation, disease severity, network analysis
- MeSH terms
- Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Prospective Studies, ROC Curve, Severity of Illness Index, Biomarkers, Survival Rate, Case-Control Studies, Cytokines, Disease Progression, Sepsis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
