Resveratrol Ameliorates Mitophagy Disturbance and Improves Cardiac Pathophysiology of Dystrophin-deficient mdx Mice
Open accessAbstract
Autophagy activation improves the phenotype in mdx mice, a Duchenne muscular dystrophy (DMD) model, although the underlying mechanisms are obscure. We previously found that resveratrol, a strong inducer of autophagy, ameliorates the cardiac pathology of mdx mice. Autophagy could eliminate damaged mitochondria, a major source of intracellular reactive oxygen species (ROS), although there is no evidence for mitochondriopathy in dystrophic cardiomyopathy. To elucidate resveratrol’s function, we investigated the deletion of mitochondrial DNA (mtDNA), autophagy of damaged mitochondria (mitophagy), and ROS accumulation in the mdx mouse heart. Low levels of normal mtDNA and abnormal accumulations of mitochondria-containing autophagosomes were found in the mdx mouse heart. Administering resveratrol to mdx mice for 56 weeks ameliorated the cardiomyopathy, with significant reductions in the amount of mtDNA deletion, the number of mitochondria-containing autophagosomes, and the ROS levels. Resveratrol induced nuclear FoxO3a accumulation and the expression of autophagy-related genes, which are targets of FoxOs. The most effective dose in mdx mice was 0.4 g resveratrol/kg food. In conclusion, resveratrol improved cardiomyopathy by promoting mitophagy in the mdx mouse heart. We propose that acquired mitochondriopathy worsens the pathology of DMD and is a potential therapeutic target for the cardiomyopathy in DMD patients.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Resveratrol can induce mitophagy via FOXO3 activation, which triggers the PINK1-Parkin pathway.
“Mitophagy can also be induced by resveratrol via FOXO3 activation, which triggers the PINK1–Parkin pathway230.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [230]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Methods in Mammalian Autophagy Research
Mizushima, N., Yoshimori, T., & Levine, B. (2010) · Cell · doi:10.1016/j.cell.2010.01.028 · Cited by 4,497 · see citing works
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works
Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells
Ikeda, R., Che, X., Yamaguchi, T., Ushiyama, M., Zheng, C., Okumura, H., Takeda, Y., Shibayama, Y., Nakamura, K. T., Jeung, H., et al. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00057.x · Cited by 2,268 · see citing works
Prevalence of Muscular Dystrophies: A Systematic Literature Review
Theadom, A., Rodrigues, M., Roxburgh, R. H., Balalla, S. K., Higgins, C., Bhattacharjee, R., Jones, K., Krishnamurthi, R., & Feigin, V. L. (2014) · Neuroepidemiology · doi:10.1159/000369343 · Cited by 2,054 · see citing works
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
Lee, I. H., Cao, L., Mostoslavsky, R., Lombard, D. B., Liu, J., Bruns, N. E., Tsokos, M., Alt, F. W., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712145105 · Cited by 1,473 · see citing works
Dynamic FoxO transcription factors
Huang, H., & Tindall, D. J. (2007) · Journal of Cell Science · doi:10.1242/jcs.001222 · Cited by 1,106 · see citing works
Milan, G., Romanello, V., Pescatore, F., Armani, A., Paik, J.-H., Frasson, L., Seydel, A., Zhao, J., Abraham, R., Goldberg, A. L., et al. (2015) · Nature Communications · doi:10.1038/ncomms7670 · Cited by 709 · see citing works
Hariharan, N., Maejima, Y., Nakae, J., Paik, J., DePinho, R. A., & Sadoshima, J. (2010) · Circulation Research · doi:10.1161/circresaha.110.227371 · Cited by 688 · see citing works
FOXO transcription factors: key regulators of cellular quality control
Webb, A. E., & Brunet, A. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.003 · Cited by 620 · see citing works
Grumati, P., Coletto, L., Sabatelli, P., Cescon, M., Angelin, A., Bertaggia, E., Blaauw, B., Urciuolo, A., Tiepolo, T., Merlini, L., et al. (2010) · Nature Medicine · doi:10.1038/nm.2247 · Cited by 540 · see citing works
Frescas, D., Valenti, L. V. C., & Accili, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412357200 · Cited by 528 · see citing works
New insights into autophagosome–lysosome fusion
Nakamura, S., & Yoshimori, T. (2017) · Journal of Cell Science · doi:10.1242/jcs.196352 · Cited by 513 · see citing works
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
Morselli, E., Mariño, G., Bennetzen, M. V., Eisenberg, T., Megalou, E. V., Schroeder, S., Cabrera, S., Bénit, P., Rustin, P., Criollo, A., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201008167 · Cited by 495 · see citing works
Self-citationRegulation of TFEB and V‐ATPases by mTORC1
Peña‐Llopis, S., Vega-Rubín-de-Celis, S., Schwartz, J. C., Wolff, N. C., Tran, T. A. T., Zou, L., Xie, X., Corey, D. R., & Brugarolas, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.257 · Cited by 456 · see citing works
Mercuri, E. M., & Francesco Muntoni, A. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61897-2 · Cited by 434 · see citing works
FoxO Transcription Factors Promote Autophagy in Cardiomyocytes
Sengupta, A., Molkentin, J. D., & Yutzey, K. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.024406 · Cited by 428 · see citing works
SIRT1 Negatively Regulates the Mammalian Target of Rapamycin
Ghosh, H. S., McBurney, M., & Robbins, P. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009199 · Cited by 397 · see citing works
What causes mitochondrial DNA deletions in human cells?
Krishnan, K. J., Reeve, A. K., Samuels, D. C., Chinnery, P. F., Blackwood, J. K., Taylor, R. W., Wanrooij, S., Spelbrink, J. N., Lightowlers, R. N., & Turnbull, D. M. (2008) · Nature Genetics · doi:10.1038/ng.f.94 · Cited by 380 · see citing works
Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress
Hori, Y. S., Kuno, A., Hosoda, R., & Horio, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073875 · Cited by 361 · see citing works
Self-citationBeckman, K. B., & Ames, B. N. (2000) · Elsevier eBooks · doi:10.1016/b978-044482650-3/50027-4 · Cited by 307 · see citing works
Dörrie, J., Gerauer, H., Wachter, Y., & Zunino, S. J. (2001) · PubMed · Cited by 292 · see citing works
mTORC1 Phosphorylates UVRAG to Negatively Regulate Autophagosome and Endosome Maturation
Kim, Y. M., Jung, C. H., Seo, M., Kim, E. K., Park, J.-M., Bae, S. S., & Kim, D. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.11.013 · Cited by 272 · see citing works
Autophagy as a new therapeutic target in Duchenne muscular dystrophy
De Palma, C., Morisi, F., Cheli, S., Pambianco, S., Cappello, V, Vezzoli, M., Rovere-Querini, P., Moggio, M., Ripolone, M., Francolini, M., et al. (2012) · Cell Death & Disease · doi:10.1038/cddis.2012.159 · Cited by 269 · see citing works
Terrill, J. R., Radley‐Crabb, H. G., Iwasaki, T., Lemckert, F. A., Arthur, P. G., & Grounds, M. D. (2013) · FEBS Journal · doi:10.1111/febs.12142 · Cited by 182 · see citing works
Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR
Liu, M., Wilk, S. A., Wang, A., Zhou, L., Wang, R.-H., Ogawa, W., Deng, C., Dong, L., & Liu, F. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.169284 · Cited by 177 · see citing works
Rothfuss, O. C., Gasser, T., & Patenge, N. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1082 · Cited by 169 · see citing works
Hori, Y. S., Kuno, A., Hosoda, R., Tanno, M., Miura, T., Shimamoto, K., & Horio, Y. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.183210 · Cited by 163 · see citing works
Self-citationThe QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number
Hunter, S. E., Jung, D., Giulio, R. T. D., & Meyer, J. N. (2010) · Methods · doi:10.1016/j.ymeth.2010.01.033 · Cited by 157 · see citing works
Rimmelé, P., Bigarella, C. L., Liang, R. H.-S., Izac, B., Dieguez‐Gonzalez, R., Barbet, G., Donovan, M. J., Brugnara, C., Blander, J. M., Sinclair, D. A., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.04.015 · Cited by 154 · see citing works
Spurney, C. F., Knoblach, S. M., Pistilli, E. E., Nagaraju, K., Martin, G. R., & Hoffman, E. P. (2008) · Neuromuscular Disorders · doi:10.1016/j.nmd.2008.03.008 · Cited by 144 · see citing works
Cellular and molecular effects of sirtuins in health and disease
Horio, Y., Hayashi, T., Kuno, A., & Kunimoto, R. (2011) · Clinical Science · doi:10.1042/cs20100587 · Cited by 137 · see citing works
Self-citationFOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress
Chaanine, A. H., Kohlbrenner, E., Gamb, S. I., Guenzel, A. J., Klaus, K. A., Fayyaz, A. U., Nair, K. S., Hajjar, R. J., & Redfield, M. M. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00549.2016 · Cited by 99 · see citing works
Kuno, A., Hori, Y. S., Hosoda, R., Tanno, M., Miura, T., Shimamoto, K., & Horio, Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.392050 · Cited by 88 · see citing works
Self-citationRedirecting TGF-β Signaling through the β-Catenin/Foxo Complex Prevents Kidney Fibrosis
Qiao, X., Rao, P., Zhang, Y., Liu, L., Pang, M., Wang, H., Hu, M., Tian, X., Zhang, J., Zhao, Y., et al. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016121362 · Cited by 80 · see citing works
Stuckey, D. J., Carr, C. A., Camelliti, P., Tyler, D. J., Davies, K. E., & Clarke, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0028569 · Cited by 79 · see citing works
Peng, T., Yu, P.-R., Chen, J., Wang, H., Wu, H.-Y., Wei, Y., & Jou, M. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.10.008 · Cited by 67 · see citing works
The cathepsin L gene is a direct target of FOXO1 in skeletal muscle
Yamazaki, Y., Kamei, Y., Sugita, S., Akaike, F., Kanai, S., Miura, S., Hirata, Y., Troen, B. R., Kitamura, T., Nishino, I., et al. (2010) · Biochemical Journal · doi:10.1042/bj20091346 · Cited by 63 · see citing works
Taneike, M., Nishida, K., Omiya, S., Zarrinpashneh, E., Misaka, T., Kitazume-Taneike, R., Austin, R., Takaoka, M., Yamaguchi, O., Gambello, M. J., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0152628 · Cited by 57 · see citing works
Deletion of mtDNA disrupts mitochondrial function and structure, but not biogenesis
Holmuhamedov, E. (2003) · Mitochondrion · doi:10.1016/s1567-7249(03)00053-9 · Cited by 36 · see citing works
Increased Mitochondrial DNA Deletions in the Skeletal Muscle of Myotonic Dystrophy
Sahashi, K., Tanaka, M., Tashiro, M., Ohno, K., Ibi, T., Takahashi, A., & Ozawa, T. (2009) · Gerontology · doi:10.1159/000213303 · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works
Autophagy and cardiac diseases: Therapeutic potential of natural products
Wu, X., Liu, Z., Yu, X., Xu, S., & Luo, J. (2020) · Medicinal Research Reviews · doi:10.1002/med.21733 · Cited by 137 · see citing works
Polyphenols as Caloric Restriction Mimetics Regulating Mitochondrial Biogenesis and Mitophagy
Davinelli, S., De Stefani, D., De Vivo, I., & Scapagnini, G. (2020) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2020.02.011 · Cited by 117 · see citing works
Mitophagy Receptors and Mediators: Therapeutic Targets in the Management of Cardiovascular Ageing
Ajoolabady, A., Aslkhodapasandhokmabad, H., Aghanejad, A., Zhang, Y., & Ren, J. T. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101129 · Cited by 103 · see citing works
Gabandé‐Rodríguez, E., Heras, M. M. G. D. L., & Mittelbrunn, M. (2019) · Cells · doi:10.3390/cells9010082 · Cited by 96 · see citing works
Islam, F., Nafady, M. H., Islam, M. R., Saha, S., Rashid, S., Akter, A., Harun-Or-Rashid, M., Akhtar, M. F., Perveen, A., Ashraf, G. M., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02859-7 · Cited by 92 · see citing works
Kuno, A., Hosoda, R., Tsukamoto, M., Sato, T., Sakuragi, H., Ajima, N., Saga, Y., Tada, K., Taniguchi, Y., Iwahara, N., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac026 · Cited by 82 · see citing works
Self-citationMitochondrial Quality Control: Role in Cardiac Models of Lethal Ischemia-Reperfusion Injury
Kulek, A. R., Anzell, A. R., Wider, J. M., Sanderson, T. H., & Przyklenk, K. (2020) · Cells · doi:10.3390/cells9010214 · Cited by 76 · see citing works
Guan, P., Sun, Z., Wang, N., Zhou, J., Luo, L.-F., Zhao, Y., & Ji, E. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116748 · Cited by 74 · see citing works
Different Antioxidative and Antiapoptotic Effects of Piceatannol and Resveratrol
Hosoda, R., Hamada, H., Uesugi, D., Iwahara, N., Nojima, I., Horio, Y., & Kuno, A. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.000096 · Cited by 73 · see citing works
Self-citationMitophagy: A promising therapeutic target for neuroprotection during ageing and age‐related diseases
Mishra, E., & Thakur, M. K. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16062 · Cited by 71 · see citing works
Mitophagy and Its Contribution to Metabolic and Aging-Associated Disorders
Liu, L., Liao, X., Wu, H., Li, Y., Zhu, Y., & Chen, Q. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.8013 · Cited by 68 · see citing works
Hosoda, R., Nakashima, R., Yano, M., Iwahara, N., Asakura, S., Nojima, I., Saga, Y., Kunimoto, R., Horio, Y., & Kuno, A. (2023) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2023.04.001 · Cited by 75 · see citing works
Self-citationDietary Mitophagy Enhancer: A Strategy for Healthy Brain Aging?
Varghese, N., Werner, S., Grimm, A., & Eckert, A. (2020) · Antioxidants · doi:10.3390/antiox9100932 · Cited by 66 · see citing works
Role of autophagy in muscle disease
Franco‐Romero, A., & Sandri, M. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.101041 · Cited by 61 · see citing works
Targeting Nrf2 for the treatment of Duchenne Muscular Dystrophy
Kourakis, S., Timpani, C. A., de Haan, J. B., Gueven, N., Fischer, D., & Rybalka, E. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101803 · Cited by 50 · see citing works
Song, H.-Y., Chien, C., Yarmishyn, A. A., Chou, S., Yang, Y., Wang, M., Wang, C., Leu, H., Yu, W.-C., Chang, Y., et al. (2019) · Cells · doi:10.3390/cells8040327 · Cited by 50 · see citing works
The Interplay of Mitophagy and Inflammation in Duchenne Muscular Dystrophy
Reid, A. L., & Alexander, M. S. (2021) · Life · doi:10.3390/life11070648 · Cited by 48 · see citing works
Canonical and Noncanonical Roles of Fanconi Anemia Proteins: Implications in Cancer Predisposition
Milletti, G., Strocchio, L., Pagliara, D., Girardi, K., Carta, R., Mastronuzzi, A., Locatelli, F., & Nazio, F. (2020) · Cancers · doi:10.3390/cancers12092684 · Cited by 44 · see citing works
Angebault, C., Panel, M., Lacôte, M., Rieusset, J., Lacampagne, A., & Fauconnier, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.609493 · Cited by 40 · see citing works
Silva‐Rojas, R., Nattarayan, V., Jaque-Fernández, F., Gómez, R., Menuet, A., Reiss, D. J., Goret, M., Messaddeq, N., Lionello, V. M., Kretz, C., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.08.006 · Cited by 40 · see citing works
Dabaj, I., Ferey, J., Marguet, F., Gilard, V., Basset, C., Bahri, Y., Bréhin, A., Vanhulle, C., Leturcq, F., Marret, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-81090-1 · Cited by 37 · see citing works
Ajoolabady, A., Bi, Y., McClements, D. J., Lip, G. Y. H., Richardson, D. R., Reiter, R. J., Klionsky, D. J., & Ren, J. T. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106072 · Cited by 39 · see citing works
Caloric restriction mimetics for the treatment of cardiovascular diseases
Sciarretta, S., Forte, M., Castoldi, F., Frati, G., Versaci, F., Sadoshima, J., Kroemer, G., & Maiuri, M. C. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa297 · Cited by 38 · see citing works
Mitochondrion: A bridge linking aging and degenerative diseases
Zhang, L., Wu, J., Zhu, Z., He, Y., & Fang, R. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121666 · Cited by 38 · see citing works
The role of polyphenols in modulating mitophagy: Implications for therapeutic interventions
Lin, X., Liu, W., Hu, X., Liu, Z., Wang, F., & Wang, J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107324 · Cited by 34 · see citing works
Ahmed, K. R., Rahman, M. M., Islam, M. N., Fahim, M. M. H., Rahman, M. A., & Kim, B. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116497 · Cited by 34 · see citing works
Kawamura, K., Fukumura, S., Nikaido, K., Tachi, N., Kozuka, N., Seino, T. H., Hatakeyama, K., Mori, M., Ito, Y. M., Takami, A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-77197-6 · Cited by 32 · see citing works
Self-citationChemical mitophagy modulators: Drug development strategies and novel regulatory mechanisms
Dong, Y. J., Zhuang, X., Wang, Y.-T., Tan, J., Feng, D., Li, M., Zhong, Q., Song, Z., Shen, H., Fang, E. F., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106835 · Cited by 33 · see citing works
Ahmad, I., & Hoda, M. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105112 · Cited by 32 · see citing works
Casati, S. R., Cervia, D., Roux-Biejat, P., Moscheni, C., Perrotta, C., & Palma, C. D. (2024) · Cells · doi:10.3390/cells13070574 · Cited by 31 · see citing works
Therapeutic Antiaging Strategies
Mishra, S. K., Balendra, V., Esposto, J., Obaid, A. A., Maccioni, R. B., Jha, N. K., Perry, G. L., Moustafa, M., Al-Shehri, M., Singh, M. P., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10102515 · Cited by 33 · see citing works
Oxidative Stress, Inflammation and Connexin Hemichannels in Muscular Dystrophies
González‐Jamett, A. M., Vásquez, W., Cifuentes-Riveros, G., Martínez-Pando, R., Sáez, J. C., & Cárdenas, A. M. (2022) · Biomedicines · doi:10.3390/biomedicines10020507 · Cited by 29 · see citing works
Resveratrol combats chronic diseases through enhancing mitochondrial quality
Tao, W., Zhang, H., Jiang, X., & Chen, N. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250140 · Cited by 29 · see citing works
Liu, M., & Wu, Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.819454 · Cited by 27 · see citing works
Kaziród, K., Myszka, M., Dulak, J., & Łoboda, A. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04636-0 · Cited by 23 · see citing works
Gandhi, S., Sweeney, H. L., Hart, C. C., Han, R., & Perry, C. G. R. (2024) · Cells · doi:10.3390/cells13141168 · Cited by 26 · see citing works
Angelini, G., Mura, G., & Messina, G. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112968 · Cited by 22 · see citing works
CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype
de Zélicourt, A., Fayssoil, A., Dakouane‐Giudicelli, M., de Jesus, I., Karoui, A., Zarrouki, F., Lefebvre, F., Mansart, A., Launay, J., Piquereau, J., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202012860 · Cited by 20 · see citing works
Has resveratrol a potential for mucopolysaccharidosis treatment?
Rintz, E., Pierzynowska, K., Podlacha, M., & Węgrzyn, G. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173534 · Cited by 21 · see citing works
Mucha, O., Kaziród, K., Podkalicka, P., Rusin, K., Dulak, J., & Łoboda, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010470 · Cited by 20 · see citing works
Xu, H., Cai, X., Xu, K., Wu, Q., & Xu, B. (2023) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-023-02885-1 · Cited by 20 · see citing works
SIRT1 deficiency interferes with membrane resealing after cell membrane injury
Fujiwara, D., Iwahara, N., Sebori, R., Hosoda, R., Shimohama, S., Kuno, A., & Horio, Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218329 · Cited by 20 · see citing works
Self-citationEffects of Plant and Animal Natural Products on Mitophagy
Shakeri, F., Bianconi, V., Pirro, M., & Sahebkar, A. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6969402 · Cited by 20 · see citing works
Ng, S. Y., Mikhail, A. I., Mattina, S. R., Manta, A., Diffey, I. J., & Ljubicic, V. (2023) · The FASEB Journal · doi:10.1096/fj.202201846rr · Cited by 18 · see citing works
Boccanegra, B., Verhaart, I. E. C., Cappellari, O., Vroom, E., & Luca, A. D. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104917 · Cited by 18 · see citing works
Mosqueira, M., Konietzny, R., Andresen, C., Wang, C., & Fink, R. (2021) · Basic Research in Cardiology · doi:10.1007/s00395-021-00860-0 · Cited by 17 · see citing works
Mitochondrial DNA Dysfunction in Cardiovascular Diseases: A Novel Therapeutic Target
Xiang, M., Yang, M., Zhang, L., Ouyang, X., Sarapultsev, A., Luo, S., & Hu, D. (2025) · Antioxidants · doi:10.3390/antiox14091138 · Cited by 17 · see citing works
Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases
Rojo, A. I., Buttari, B., Cadenas, S., Carlos, A. R., Cuadrado, A., Falcão, A. S., López, M. G., Georgiev, M. I., Grochot‐Przeczek, A., Gumeni, S., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103464 · Cited by 15 · see citing works
Distal myopathy due to TCAP variants in four unrelated Chinese patients
Lv, X., Gao, F., Dai, T., Zhao, D., Jiang, W., Geng, H., Liu, F., Lin, P., & Yan, C. (2020) · Neurogenetics · doi:10.1007/s10048-020-00623-4 · Cited by 14 · see citing works
Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice
Ziemba, M., Barkhouse, M., Uaesoontrachoon, K., Giri, M., Hathout, Y., Dang, U. J., Gordish‐Dressman, H., Nagaraju, K., & Hoffman, E. P. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246507 · Cited by 14 · see citing works
ATG14 and RB1CC1 play essential roles in maintaining muscle homeostasis
Li, D., Vogel, P., Li-Harms, X., Wang, B., & Kundu, M. (2021) · Autophagy · doi:10.1080/15548627.2021.1911549 · Cited by 12 · see citing works
A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy
Domi, E., Hoxha, M., Prendi, E., & Zappacosta, B. (2021) · Cells · doi:10.3390/cells10061380 · Cited by 12 · see citing works
Nakashima, R., Hosoda, R., Tatekoshi, Y., Iwahara, N., Saga, Y., & Kuno, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-51746-9 · Cited by 11 · see citing works
Self-citationSilva‐Rojas, R., Pérez‐Guàrdia, L., Lafabrie, E., Moulaert, D., Laporte, J., & Böhm, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136968 · Cited by 11 · see citing works
Jayatunga, D. P. W., Hone, E., Fernando, W. M. A. D. B., Garg, M. L., Verdile, G., & Martins, R. N. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.781468 · Cited by 11 · see citing works
Lv, X., Zhang, R., Xu, L., Wang, G., Yan, C., & Lin, P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.836464 · Cited by 11 · see citing works
Bonato, A., Raparelli, G., & Caruso, M. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1496870 · Cited by 10 · see citing works
An anti-ADAMTS1 treatment relieved muscle dysfunction and fibrosis in dystrophic mice
Wang, Y., Xiao, Y., Zheng, Y., Yang, L., & Wang, D. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119756 · Cited by 10 · see citing works
Cardioprotective effect of nicorandil on isoproterenol induced cardiomyopathy in the Mdx mouse model
Sullivan, R. T., Lam, N. T., Haberman, M., Beatka, M. J., Afzal, M. Z., Lawlor, M. W., & Strande, J. L. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-021-02112-4 · Cited by 10 · see citing works
Activation of SIRT1 promotes membrane resealing via cortactin
Iwahara, N., Azekami, K., Hosoda, R., Nojima, I., Hisahara, S., & Kuno, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-19136-1 · Cited by 10 · see citing works
Self-citationResveratrol promotes autophagosome elimination via SIRT1 in cardiomyocytes
Kuno, A., Hosoda, R., Saga, Y., Iwahara, N., Tatekoshi, Y., Numazawa, R., & Horio, Y. (2024) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2024.11.006 · Cited by 8 · see citing works
Self-citationPinker, S. A., & Ullman, M. T. (2002) · Cited by 8 · see citing works
Zhang, J., Huang, J., Lan, J., Li, Q., Ke, L., Jiang, Q., Li, Y., Zhang, H., Zhong, H., Yang, P., et al. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13253 · Cited by 7 · see citing works
Armengol, E. G., Merckx, C., Sutter, H. D., Bleecker, J. D., & Paepe, B. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020439 · Cited by 7 · see citing works
Sarkar, S., Chattopadhyay, A., & Bandyopadhyay, D. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123890 · Cited by 6 · see citing works
Klotho Is Cardioprotective in the mdx Mouse Model of Duchenne Muscular Dystrophy
Javier, A. J. S., Kennedy, F. M., Yi, X., Wehling‐Henricks, M., Tidball, J. G., White, K. E., Witczak, C. A., Kuro‐o, M., & Welc, S. S. (2025) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.12.017 · Cited by 4 · see citing works
Bozzi, M., Sciandra, F., Bigotti, M. G., & Brancaccio, A. (2025) · Cells · doi:10.3390/cells14100721 · Cited by 4 · see citing works
Bal, N. B., Sadı, G., Bostancı, A., Kiremitçi, S., Adanir, I., Uludağ, M. O., & Demirel-Yılmaz, E. (2025) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001744 · Cited by 3 · see citing works
Kuo, C., Manastireanu, D. M., Nieto-Torres, J. L., & Kumsta, C. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl38730 · Cited by 3 · see citing works
Ng, S. Y., Mikhail, A. I., Mattina, S. R., Lesinski, M. A., Rebalka, I. A., Hamstra, S. I., Xhuti, D., Fajardo, V. A., Tarnopolsky, M. A., Nederveen, J. P., et al. (2026) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70200 · Cited by 3 · see citing works
Exogenous and Endogenous Molecules Potentially Proficient to Modulate Mitophagy in Cardiac Disorders
Nakashima, M., Suga, N., & Matsuda, S. (2024) · Kinases and Phosphatases · doi:10.3390/kinasesphosphatases2020010 · Cited by 3 · see citing works
Wijekoon, N., Gonawala, L., Ratnayake, P. D., Sirisena, D., Gunasekara, H., Dissanayake, A., Amaratunga, D., Steinbusch, H. W. M., Hathout, Y., Hoffman, E. P., et al. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1482999 · Cited by 3 · see citing works
Rejiepu, M., Shen, J., Liang, J., Maitikabili, A., Yang, J., Zhang, L., & Mi, N. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.4501 · Cited by 3 · see citing works
Vorwald, M. E., Krishna, S., Lee, J. H., Roths, M. S., Valentine, R. J., & Selsby, J. T. (2026) · The Journal of Physiology · doi:10.1113/jp289832 · Cited by 2 · see citing works
He, L., & Tong, J. (2022) · Natural Product Communications · doi:10.1177/1934578x221109410 · Cited by 2 · see citing works
Key Cellular Effectors in ROS-Mediated Cardiac Diseases
Chaudhuri, R. D., Rana, S., Datta, K., & Sarkar, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-8946-7_7 · Cited by 2 · see citing works
Exploring new therapeutics for Duchenne muscular dystrophy and related cardiomyopathy
Li, B., Xiong, W., Chang, A. C. H., & Chang, A. C. Y. (2025) · Rare Disease and Orphan Drugs Journal · doi:10.20517/rdodj.2024.44 · Cited by 1 · see citing works
Wang, Y., Bao, Y., Deng, X., Duan, H., Wang, Y., Li, H., Zhang, J., Li, J., Han, X., Li, P., et al. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119153 · Cited by 1 · see citing works
Tao, Z., Shi, L., & Cheng, Z. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160608-00164
Autophagy as a Pathogenetic Link and a Target for Therapy of Musculoskeletal System Diseases
Kalugina, K. K., Сухарева, К. С., Churkina, A. I., & Kostareva, A. A. (2021) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093021030145
Hirata, T., Baba, S., Akagi, K., Matsuda, K., Umeda, K., Adachi, S., Heike, T., & Takita, J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0297083
Mitophagy inducers as potential therapeutic agents
D'Arcy, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15260-3.00004-1
Gandhi, S., Delfinis, L. J., Bhatt, P. D., Garibotti, M. C., Bellissimo, C. A., Goli, A. N., Morris, B. A., Brahmbhatt, A. N., Yakobov-Shimonov, S., Rahman, F. A., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102179
DREAMS: Drug REpurposing with Artificial Intelligence for Muscular Disorders
Miagoux, Q., Brullé, L., Lemoine, J., Maignan, N., Ravinder, R., Khazen, W., Méjat, A., Moparthi, S. B., Vassilopoulos, S., Forand, A., et al. (2025) · Drug repurposing · doi:10.58647/drugrepo.25.1.0006
Bereznikova, D. A., & Stanojević, U. S. (2026) · Siberian Journal of Oncology · doi:10.21294/1814-4861-2026-25-1-146-154
Targeting FOXO3 for the Management of Heart Failure: Current Evidence and Future Directions
Park, S. (2026) · Pharmaceuticals · doi:10.3390/ph19091460
Kuno, A., Saga, Y., Hosoda, R., Aida, H., Kurihara, A., Tatekoshi, Y., Abe, K., Numazawa, R., & Iwahara, N. (2026) · The FASEB Journal · doi:10.1096/fj.202601047r
Self-citation
- Authors
- Kuno, A., Hosoda, R., Sebori, R., Hayashi, T., Sakuragi, H., Tanabe, M., & Horio, Y.
- Affiliations
- Sapporo Medical University (JP)
- Corresponding author
- Kuno, Atsushi
- Venue
- Scientific Reports
- Published
- 2018-10-22
- Volume
- 8
- Issue
- 1
- Pages
- 15555-15555
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6197260
- OpenAlex
- W2896564721
- Cited by
- 88
- References
- 40
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 12 · 2023: 7 · 2022: 14 · 2021: 14 · 2020: 17 · 2019: 5
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Japan Research Foundation for Clinical Pharmacology
- Suhara Memorial Foundation
- Japan Society for the Promotion of Science (18K06965, 15K08312)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- resveratrol, mitophagy, Duchenne muscular dystrophy, mdx mice, dystrophic cardiomyopathy, mitochondrial DNA deletions, reactive oxygen species, FOXO3, autophagy, cardiac pathology
- MeSH terms
- Resveratrol, Animals, Antioxidants, Cardiotonic Agents, Disease Models, Animal, Myocardium, Dystrophin, Treatment Outcome, Reactive Oxygen Species, Mice, Inbred mdx, Muscular Dystrophy, Duchenne, Mitophagy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
