Cited by 117Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Polyphenols as Caloric Restriction Mimetics Regulating Mitochondrial Biogenesis and Mitophagy

Davinelli, Sergio, De Stefani, Diego, De Vivo, Immaculata, Scapagnini, Giovanni·2020·Trends in Endocrinology & Metabolism

Abstract

The tight coordination between mitochondrial biogenesis and mitophagy can be dysregulated during aging, critically influencing whole-body metabolism, health, and lifespan. To date, caloric restriction (CR) appears to be the most effective intervention strategy to improve mitochondrial turnover in aging organisms. The development of pharmacological mimetics of CR has gained attention as an attractive and potentially feasible approach to mimic the CR phenotype. Polyphenols, ubiquitously present in fruits and vegetables, have emerged as well-tolerated CR mimetics that target mitochondrial turnover. Here, we discuss the molecular mechanisms that orchestrate mitochondrial biogenesis and mitophagy, and we summarize the current knowledge of how CR promotes mitochondrial maintenance and to what extent different polyphenols may mimic CR and coordinate mitochondrial biogenesis and clearance.

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Crossref · 10.1016/j.tem.2020.02.011

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Authors
Davinelli, S., De Stefani, D., De Vivo, I., & Scapagnini, G.
Affiliations
University of Molise (IT)
Corresponding author
Davinelli, Sergio
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2020-07
Volume
31
Issue
7
Pages
536-550
ISSN
1043-2760 (ISSN-L)
OpenAlex
W3011512734
Cited by
117
References
98
Citations by year
2026: 8 · 2025: 20 · 2024: 21 · 2023: 11 · 2022: 35 · 2021: 17 · 2020: 5
FWCI
2.48
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Funders
Paolo Sorbini Foundation
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords
polyphenols, caloric restriction mimetics, mitochondrial biogenesis, mitophagy, aging, mitochondrial turnover, lifespan, mitochondrial maintenance
MeSH terms
Animals, Humans, Mitochondria, Caloric Restriction, Polyphenols, Mitophagy

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