Polyphenols as Caloric Restriction Mimetics Regulating Mitochondrial Biogenesis and Mitophagy
Abstract
The tight coordination between mitochondrial biogenesis and mitophagy can be dysregulated during aging, critically influencing whole-body metabolism, health, and lifespan. To date, caloric restriction (CR) appears to be the most effective intervention strategy to improve mitochondrial turnover in aging organisms. The development of pharmacological mimetics of CR has gained attention as an attractive and potentially feasible approach to mimic the CR phenotype. Polyphenols, ubiquitously present in fruits and vegetables, have emerged as well-tolerated CR mimetics that target mitochondrial turnover. Here, we discuss the molecular mechanisms that orchestrate mitochondrial biogenesis and mitophagy, and we summarize the current knowledge of how CR promotes mitochondrial maintenance and to what extent different polyphenols may mimic CR and coordinate mitochondrial biogenesis and clearance.
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Several polyphenols improve mitochondrial physiology.
“Among them, several polyphenols that improve mitochondrial physiology have been described223.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [223]
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Effects of resveratrol on regulation on UCP2 and cardiac function in diabetic rats
Diao, J., Wei, J. J., Yan, R., Fan, G., Lin, L., & Chen, M. (2018) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-018-0648-7 · Cited by 43 · see citing works
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Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works
Caloric Restriction Mimetics in Nutrition and Clinical Trials
Hofer, S. J., Davinelli, S., Bergmann, M., Scapagnini, G., & Madeo, F. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.717343 · Cited by 109 · see citing works
Self-citationFermented Soy Products: Beneficial Potential in Neurodegenerative Diseases
Jang, C. H., Oh, J., Lim, J. S., Kim, H. J., & Kim, J.-S. (2021) · Foods · doi:10.3390/foods10030636 · Cited by 100 · see citing works
Chen, X., He, Q., Zhai, Q., Tang, H., Li, D., Zhu, X., Zheng, X., Jian, G., Cannon, R. D., Mei, L., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c08165 · Cited by 78 · see citing works
- Authors
- Davinelli, S., De Stefani, D., De Vivo, I., & Scapagnini, G.
- Affiliations
- University of Molise (IT)
- Corresponding author
- Davinelli, Sergio
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 31
- Issue
- 7
- Pages
- 536-550
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W3011512734
- Cited by
- 117
- References
- 98
- Citations by year
- 2026: 8 · 2025: 20 · 2024: 21 · 2023: 11 · 2022: 35 · 2021: 17 · 2020: 5
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Paolo Sorbini Foundation
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- polyphenols, caloric restriction mimetics, mitochondrial biogenesis, mitophagy, aging, mitochondrial turnover, lifespan, mitochondrial maintenance
- MeSH terms
- Animals, Humans, Mitochondria, Caloric Restriction, Polyphenols, Mitophagy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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