Common functional alterations identified in blood transcriptome of autoimmune cholestatic liver and inflammatory bowel diseases
Open accessAbstract
Primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis (UC), are heterogeneous chronic autoimmune diseases that may share underlying pathogenic mechanisms. Herein, we compared simultaneously analyzed blood transcriptomes from patients with PBC, PSC, and IBD. Microarray-based measurements were conducted using RNA isolated from whole blood samples from 90, 45, 95 and 93 patients with PBC, PSC, CD, and UC, respectively, and 47 healthy controls. Expression levels of selected transcripts were analyzed by quantitative reverse-transcribed PCR using an independent cohort of 292, 71 and 727 patients with PBC, PSC, and IBD, respectively. Of 4026, 2650 and 4967 probe sets differentially expressed (adjusted p-value < 0.05) in samples from patients with PBC, PSC, and IBD, respectively, compared with healthy controls, 1946 were common to all three comparisons. Functional analyses indicated that most terms enriched for genes differentially expressed in PBC, PSC, and IBD patients compared with healthy controls were related to mitochondrial function, the vesicle endomembrane system, and GTPase-mediated processes. This study indicates that microarray-based profiling of blood gene expression supports research into the molecular mechanisms underlying disease, rather than being useful for selection of diagnostic biomarkers for use in clinical practice.
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ARID3A expression in whole blood is marginally but significantly increased in PBC patients compared to healthy controls.
“The results showed a marginal but significant increase in ARID3A expression in whole blood cells from PBC compared to HCs (Fig. 6C).”
From A regulatory variant at 19p13.3 is associated with primary biliary cholangitis risk and ARID3A expression (2023) · cites this paper as [20]
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- Authors
- Ostrowski, J., Goryca, K., Lazowska, I., Rogowska, A., Paziewska, A., Dabrowska, M., Ambrozkiewicz, F., Karczmarski, J., Balabas, A., Kluska, A., Piatkowska, M., Zeber-Lubecka, N., Kulecka, M., Habior, A., Mikula, M., The Polish PBC study Group, Walewska-Zielecka, B., Krawczyk, M., Cichoz-Lach, H., Milkiewicz, P., Kowalik, A., Mucha, K., Raczynska, J., Musialik, J., Boryczka, G., Wasilewicz, M., Ciecko-Michalska, I., Ferenc, M., Janiak, M., Kanikowska, A., Stankiewicz, R., Hartleb, M., Mach, T., Grzymislawski, M., Raszeja-Wyszomirska, J., Wunsch, E., Bobinski, T., The Polish IBD study Group, Kierkus, J., Socha, P., Lodyga, M., Klopocka, M., Iwanczak, B., Bak-Drabik, K., Walkowiak, J., Radwan, P., Grzybowska-Chlebowczyk, U., Korczowski, B., & Starzynska, T.
- Affiliations
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Medical University of Warsaw (PL)
- Medical University of Lublin (PL)
- Medical University of Silesia (PL)
- Poznan University of Medical Sciences (PL)
- Jagiellonian University (PL)
- Pomeranian Medical University (PL)
- Children's Memorial Health Institute (PL)
- Nicolaus Copernicus University (PL)
- University of Rzeszów (PL)
- Corresponding author
- Ostrowski, Jerzy
- Habior, Andrzej
- ORCID
- Ostrowski, Jerzy
- Goryca, Krzysztof
- Rogowska, Agnieszka
- Paziewska, Agnieszka
- Karczmarski, Jakub
- Kluska, Anna
- Kulecka, Maria
- Habior, Andrzej
- Krawczyk, Marek
- Milkiewicz, Piotr
- Kowalik, Agnieszka
- Mucha, Krzysztof
- Musialik, Joanna
- Boryczka, Grzegorz
- Janiak, Maria
- Kanikowska, Alina
- Hartleb, Marek
- Grzymislawski, Marian
- Wunsch, Ewa
- Socha, Piotr
- Radwan, Piotr
- Korczowski, Bartosz
- Venue
- Scientific Reports
- Published
- 2019-05-10
- Volume
- 9
- Issue
- 1
- Pages
- 7190-7190
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6510750
- OpenAlex
- W2943921438
- Cited by
- 36
- References
- 72
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 4 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by-nc-nd)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- Funders
- Narodowe Centrum Nauki (2011/02/A/NZ5/00339, 2011/01/B/NZ5/05291)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- primary biliary cirrhosis, primary sclerosing cholangitis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, blood transcriptome, differentially expressed genes, mitochondrial function, autoimmune liver disease, shared pathogenesis
- MeSH terms
- Adolescent, Adult, Aged, Child, Child, Preschool, Female, Gene Expression Regulation, Humans, Infant, Liver Cirrhosis, Biliary, Male, Middle Aged, RNA, Messenger, Cholangitis, Sclerosing, Inflammatory Bowel Diseases, Case-Control Studies, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Gene Regulatory Networks, Young Adult
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