Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis
Abstract
Summary: We selected 42 early‐stage primary biliary cirrhosis (PBC) patients and 30 healthy controls (HC). Metagenomic sequencing of the 16S rRNA gene was used to characterize the fecal microbiome. UPLC‐MS/MS assaying of small molecules was used to characterize the metabolomes of the serum, urine and feces. Liquid chip assaying of serum cytokines was used to characterize the immune profiles. The gut of PBC patients were depleted of some potentially beneficial bacteria, such as Acidobacteria, Lachnobacterium sp., Bacteroides eggerthii and Ruminococcus bromii , but were enriched in some bacterial taxa containing opportunistic pathogens, such as γ‐Proteobacteria, Enterobacteriaceae, Neisseriaceae, Spirochaetaceae , Veillonella , Streptococcus , Klebsiella , Actinobacillus pleuropneumoniae , Anaeroglobus geminatus , Enterobacter asburiae , Haemophilus parainfluenzae , Megasphaera micronuciformis and Paraprevotella clara . Several altered gut bacterial taxa exhibited potential interactions with PBC through their associations with altered metabolism, immunity and liver function indicators, such as those of Klebsiella with IL‐2A and Neisseriaceae with urinary indoleacrylate. Many gut bacteria, such as some members of Bacteroides, were altered in their associations with the immunity and metabolism of PBC patients, although their relative abundances were unchanged. Consequently, the gut microbiome is altered and may be critical for the onset or development of PBC by interacting with metabolism and immunity.
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The gut microbiomes of patients with advanced liver disease and cirrhosis are characterized by increased potentially pathogenic bacteria and reduced beneficial bacteria.
“The gut microbiomes of patients with advanced liver disease and cirrhosis are characterized by an increase in potentially pathogenic bacteria, along with reduced numbers of bacteria with beneficial properties32,84,85.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [85]
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- Authors
- Lv, L., Fang, D., Shi, D., Chen, D., Yan, R., Zhu, Y., Chen, Y., Shao, L., Guo, F., Wu, W., Li, A., Shi, H., Jiang, X., Jiang, H., Xiao, Y., Zheng, S., & Li, L.
- Affiliations
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003 Hangzhou China
- First Affiliated Hospital Zhejiang University (CN)
- ORCID
- Li, Ang
- Venue
- Environmental Microbiology
- Publisher
- Wiley
- Published
- 2016-07
- Volume
- 18
- Issue
- 7
- Pages
- 2272-2286
- ISSN
- 1462-2912 (ISSN-L)
- 1462-2920
- OpenAlex
- W2462265698
- Cited by
- 245
- References
- 34
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 43 · 2023: 23 · 2022: 33 · 2021: 28 · 2020: 25 · 2019: 30 · 2018: 13 · 2017: 19 · 2016: 1
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Environmental Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (NSFC) (81570512)
- National Basic Research Program of China (973 program) (2013CB531401)
- NSFC (81330011)
- Fundamental Research Funds for the Central Universities (2015FZA7014)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- primary biliary cirrhosis, gut microbiota, fecal microbiota, serum metabolome, urinary metabolome, serum cytokines, opportunistic pathogens, Bacteroides, Klebsiella, Neisseriaceae, host-microbe interactions, liver function indicators
- MeSH terms
- Gastrointestinal Microbiome, Bacteria, Feces, Female, Humans, Liver Cirrhosis, Biliary, Male, Middle Aged, Gastrointestinal Tract, Metagenomics
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