The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles
Open accessAbstract
Capable of generating plasmonic and other effects, gold nanostructures can offer a variety of diagnostic and therapy functionalities for biomedical applications, but conventional chemically-synthesized Au nanomaterials cannot always match stringent requirements for toxicity levels and surface conditioning. Laser-synthesized Au nanoparticles (AuNP) present a viable alternative to chemical counterparts and can offer exceptional purity (no trace of contaminants) and unusual surface chemistry making possible direct conjugation with biocompatible polymers (dextran, polyethylene glycol). This work presents the first pharmacokinetics, biodistribution and safety study of laser-ablated dextran-coated AuNP (AuNPd) under intravenous administration in small animal model. Our data show that AuNPd are rapidly eliminated from the blood circulation and accumulated preferentially in liver and spleen, without inducing liver or kidney toxicity, as confirmed by the plasmatic ALAT and ASAT activities, and creatininemia values. Despite certain residual accumulation in tissues, we did not detect any sign of histological damage or inflammation in tissues, while IL-6 level confirmed the absence of any chronic inflammation. The safety of AuNPd was confirmed by healthy behavior of animals and the absence of acute and chronic toxicities in liver, spleen and kidneys. Our results demonstrate that laser-synthesized AuNP are safe for biological systems, which promises their successful biomedical applications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering
Nie, S., & Emory, S. R. (1997) · Science · doi:10.1126/science.275.5303.1102 · Cited by 10,238
Synthesis of thiol-derivatised gold nanoparticles in a two-phase Liquid–Liquid system
Brust, M., Walker, M., Bethell, D., Schiffrin, D. J., & Whyman, R. (1994) · J. Chem. Soc., Chem. Commun. · doi:10.1039/c39940000801 · Cited by 6,707
Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods
Huang, X., El-Sayed, I. H., Qian, W., & El-Sayed, M. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja057254a · Cited by 5,436
Jain, P. K., Lee, K. S., El-Sayed, I. H., & El-Sayed, M. A. (2006) · The Journal of Physical Chemistry B · doi:10.1021/jp057170o · Cited by 4,603
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
Hirsch, L. R., Stafford, R. J., Bankson, J. A., Sershen, S. R., Rivera, B., Price, R. E., Hazle, J. D., Halas, N. J., & West, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232479100 · Cited by 3,955
The golden age: gold nanoparticles for biomedicine
Dreaden, E. C., Alkilany, A. M., Huang, X., Murphy, C. J., & El-Sayed, M. A. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15237h · Cited by 3,550
The blood-brain barrier/neurovascular unit in health and disease
Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661
Gold Nanoparticles Are Taken Up by Human Cells but Do Not Cause Acute Cytotoxicity
Connor, E. E., Mwamuka, J., Gole, A., Murphy, C. J., & Wyatt, M. D. (2005) · Small · doi:10.1002/smll.200400093 · Cited by 2,406
Turkevich Method for Gold Nanoparticle Synthesis Revisited
Kimling, J., Maier, M., Okenve, B., Kotaidis, V., Ballot, H., & Plech, A. (2006) · The Journal of Physical Chemistry B · doi:10.1021/jp061667w · Cited by 2,281
Nano-optics from sensing to waveguiding
Lal, S., Link, S., & Halas, N. J. (2007) · Nature Photonics · doi:10.1038/nphoton.2007.223 · Cited by 2,138
Cited by
Kus-Liśkiewicz, M., Fickers, P., & Ben Tahar, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010952 · Cited by 404
Biosynthesis of Gold and Silver Nanoparticles Using Phytochemical Compounds
Zuhrotun, A., Oktaviani, D. J., & Hasanah, A. N. (2023) · Molecules · doi:10.3390/molecules28073240 · Cited by 281
Domingues, C., Santos, A., Alvarez-Lorenzo, C., Concheiro, A., Jarak, I., Veiga, F., Barbosa, I., Dourado, M., & Figueiras, A. (2022) · ACS Nano · doi:10.1021/acsnano.2c00128 · Cited by 235
Anti-inflammatory role of gold nanoparticles in the prevention and treatment of Alzheimer's disease
Aili, M., Zhou, K., Zhan, J., Zheng, H., & Luo, F. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01023f · Cited by 80
Yang, J., Luly, K. M., & Green, J. J. (2023) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1853 · Cited by 40
Metadata
- Authors
- Bailly, A.-L., Correard, F., Popov, A., Tselikov, G., Chaspoul, F., Appay, R., Al-Kattan, A., Kabashin, A. V., Braguer, D., & Esteve, M.-A.
- Venue
- Scientific Reports
- Published
- 2019-09-09
- Volume
- 9
- Issue
- 1
- Pages
- 12890-12890
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2973014626
- Cited by
- 283
- References
- 74
- FWCI
- 12.52
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles. https://app.cochat.ai/papers/10.1038/s41598-019-48748-3
- The paper
- Bailly, A.-L., Correard, F., Popov, A., Tselikov, G., Chaspoul, F., Appay, R., Al-Kattan, A., Kabashin, A. V., Braguer, D., & Esteve, M.-A. (2019). In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles. Scientific Reports. https://doi.org/10.1038/s41598-019-48748-3
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
