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Cited by 334

The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.

Effects of Chlorhexidine mouthwash on the oral microbiome

Open access
Bescos, Raul, Ashworth, Ann, Clarke, Craig, Brookes, Zoe L., Belfield, Louise, Rodiles, Ana, Casas-Agustench, Patricia, Farnham, Garry, Liddle, Luke, Burleigh, Mia, White, Desley, Easton, Chris, Hickson, Mary·2020·Scientific Reports
DOI 10.1038/s41598-020-61912-4
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Abstract

Following a single blind, cross-over and non-randomized design we investigated the effect of 7-day use of chlorhexidine (CHX) mouthwash on the salivary microbiome as well as several saliva and plasma biomarkers in 36 healthy individuals. They rinsed their mouth (for 1 min) twice a day for seven days with a placebo mouthwash and then repeated this protocol with CHX mouthwash for a further seven days. Saliva and blood samples were taken at the end of each treatment to analyse the abundance and diversity of oral bacteria, and pH, lactate, glucose, nitrate and nitrite concentrations. CHX significantly increased the abundance of Firmicutes and Proteobacteria, and reduced the content of Bacteroidetes, TM7, SR1 and Fusobacteria. This shift was associated with a significant decrease in saliva pH and buffering capacity, accompanied by an increase in saliva lactate and glucose levels. Lower saliva and plasma nitrite concentrations were found after using CHX, followed by a trend of increased systolic blood pressure. Overall, this study demonstrates that mouthwash containing CHX is associated with a major shift in the salivary microbiome, leading to more acidic conditions and lower nitrite availability in healthy individuals.

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Crossref · 10.1038/s41598-020-61912-4

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Metadata

Authors
Bescos, R., Ashworth, A., Clarke, C., Brookes, Z. L., Belfield, L., Rodiles, A., Casas-Agustench, P., Farnham, G., Liddle, L., Burleigh, M., White, D., Easton, C., & Hickson, M.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2020-03-24
Volume
10
Issue
1
Pages
103768-103768
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-020-61912-4
OpenAlex
W3013077408
Cited by
334
References
102
FWCI
35.78
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Effects of Chlorhexidine mouthwash on the oral microbiome. https://app.cochat.ai/papers/10.1038/s41598-020-61912-4
The paper
Bescos, R., Ashworth, A., Clarke, C., Brookes, Z. L., Belfield, L., Rodiles, A., Casas-Agustench, P., Farnham, G., Liddle, L., Burleigh, M., White, D., Easton, C., & Hickson, M. (2020). Effects of Chlorhexidine mouthwash on the oral microbiome. Scientific Reports. https://doi.org/10.1038/s41598-020-61912-4

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.