Gut microbiota dysbiosis associated with bile acid metabolism in neonatal cholestasis disease
Open accessAbstract
Neonatal cholestasis disease (NCD) is a complex and easily mis-diagnosed condition. We analyzed microbiota community structure in feces and measured short-chain fatty acids, bile acids (BAs) and liver function of 12 healthy, 13 NCD, and 13 treated infants after diagnosis. Based on 16S rRNA gene amplicon sequencing and gas-chromatographic-mass-spectrometric analysis of secondary BAs, we identified microbial genera and metabolites that associate with abnormal bile secretion. Streptococcus gallolyticus and Parabacteroides distasonis, and Lactobacillus gasseri had higher relative abundance in healthy and NCD infants respectively. Compared to NCD patients, healthy infants had higher LCA, CDCA and GCDCA fecal concentrations. The three microbial species and three secondary bile acids were selected as potential non-invasive combined biomarkers to diagnose NCD. We propose that microbiota-metabolite combined biomarkers could be used for diagnosis of NCD, and this may contribute to improved early clinical diagnosis of NCD in the future.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Neonatal cholestasis is associated with dysbiosis in infants.
“Postnatal maturation of the GM in newborn mice was shown to be dependent on BAs and neonatal cholestasis is associated with dysbiosis in infants (326, 327).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [327]
Postnatal maturation of the gut microbiota in newborn mice is dependent on bile acids.
“Postnatal maturation of the GM in newborn mice was shown to be dependent on BAs and neonatal cholestasis is associated with dysbiosis in infants (326, 327).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [327]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
UPARSE: highly accurate OTU sequences from microbial amplicon reads
Edgar, R. C. (2013) · Nature Methods · doi:10.1038/nmeth.2604 · Cited by 16,587 · see citing works
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works
Duodenal Infusion of Donor Feces for Recurrent <i>Clostridium difficile</i>
van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E. G., de Vos, W. M., Visser, C. E., Kuijper, E. J., Bartelsman, J. F. W. M., Tijssen, J. G. P., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1205037 · Cited by 3,708 · see citing works
Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism
Wahlstrom, A. M., Sayin, S. I., Marschall, H., & Bäckhed, F. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.005 · Cited by 2,903 · see citing works
Bile salt biotransformations by human intestinal bacteria
Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829 · see citing works
Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331 · see citing works
Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes
Zhao, L., Zhang, F., Ding, X., Wu, G., Lam, Y. Y., Wang, X., Fu, H., Xue, X., Lu, C., Ma, J., et al. (2018) · Science · doi:10.1126/science.aao5774 · Cited by 2,304 · see citing works
Alterations of the human gut microbiome in liver cirrhosis
Qin, N., Yang, F., Li, A., Prifti, E., Chen, Y., Shao, L., Guo, J., Le Chatelier, E., Yao, J., Wu, L., et al. (2014) · Nature · doi:10.1038/nature13568 · Cited by 2,177 · see citing works
Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
Zhu, W., Gregory, J. C., Org, E., Buffa, J. A., Gupta, N., Wang, Z., Li, L., Fu, X., Wu, Y., Mehrabian, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.011 · Cited by 1,968 · see citing works
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
Buffie, C. G., Bucci, V., Stein, R. R., McKenney, P. T., Ling, L., Gobourne, A., No, D., Liu, H., Kinnebrew, M., Viale, A., et al. (2015) · Nature · doi:10.1038/nature13828 · Cited by 1,872 · see citing works
Yu, J. Q., Feng, Q., Wong, S. H., Zhang, D., Liang, Q. Y., Qin, Y., Tang, L., Zhao, H., Stenvang, J., Li, Y., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-309800 · Cited by 1,247 · see citing works
Wang, K., Liao, M., Zhou, N., Bao, L., Ma, K., Zheng, Z., Wang, Y., Liu, C., Wang, W., Wang, J., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.028 · Cited by 1,166 · see citing works
Self-citationThe Intestinal Microbiota in Colorectal Cancer.
Tilg, H., Adolph, T. E., Gerner, R. R., & Moschen, A. R. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.004 · Cited by 777 · see citing works
Wang, Y., Song, F., Zhu, J., Zhang, S., Yang, Y., Chen, T., Tang, B., Dong, L., Ding, N., Zhang, Q., et al. (2017) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2017.01.001 · Cited by 693 · see citing works
Role of gut microbiota in atherosclerosis
Jonsson, A. L., & Bäckhed, F. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.183 · Cited by 647 · see citing works
Guideline for the Evaluation of Cholestatic Jaundice in Infants
Fawaz, R. L., Baumann, U., Ekong, U. D., Fischler, B., Hadžić, N., Mack, C. L., McLin, V. A., Molleston, J. P., Neimark, E., Ng, V. L., et al. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001334 · Cited by 557 · see citing works
Hypertension-Linked Pathophysiological Alterations in the Gut
Santisteban, M. M., Qi, Y., Zubcevic, J., Kim, S., Yang, T., Shenoy, V., Cole-Jeffrey, C. T., Lobaton, G. O., Stewart, D. C., Rubiano, A., et al. (2017) · Circulation Research · doi:10.1161/circresaha.116.309006 · Cited by 525 · see citing works
Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life
Yassour, M., Jason, E., Hogstrom, L. J., Arthur, T. D., Tripathi, S., Siljander, H., Selvenius, J., Oikarinen, S., Hyöty, H., Virtanen, S. M., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.06.007 · Cited by 455 · see citing works
Beyond intestinal soap—bile acids in metabolic control
Kuipers, F., Bloks, V. W., & Groen, A. K. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.60 · Cited by 453 · see citing works
Moyer, V. A., Freese, D. K., Whitington, P. F., Olson, A. D., Brewer, F., Colletti, R. B., & Heyman, M. B. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200408000-00001 · Cited by 402 · see citing works
Gu, Y., Wang, X., Li, J., Zhang, Y., Zhong, H., Liu, R., Zhang, D., Feng, Q., Xie, X., Hong, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01682-2 · Cited by 396 · see citing works
Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders
Kang, D.-W., Ilhan, Z. E., Isern, N. G., Hoyt, D. W., Howsmon, D. P., Shaffer, M., Lozupone, C. A., Hahn, J., Adams, J. B., & Krajmalnik-Brown, R. (2018) · Anaerobe · doi:10.1016/j.anaerobe.2017.12.007 · Cited by 381 · see citing works
Heinken, A., Ravcheev, D. A., Baldini, F., Heirendt, L., Fleming, R. M. T., & Thiele, I. (2019) · Microbiome · doi:10.1186/s40168-019-0689-3 · Cited by 335 · see citing works
Fecal bacteria act as novel biomarkers for noninvasive diagnosis of colorectal cancer
Liang, Q., Chiu, J., Chen, Y., Huang, Y., Higashimori, A., Fang, J., Brim, H., Ashktorab, H., Ng, S. C., Ng, S. S. M., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-1599 · Cited by 332 · see citing works
Self-citationHartmann, P., Hochrath, K., Horvath, A., Chen, P., Seebauer, C. T., Llorente, C., Wang, L., Alnouti, Y., Fouts, D. E., Stärkel, P., et al. (2018) · Hepatology · doi:10.1002/hep.29676 · Cited by 290 · see citing works
Wu, T., Zhang, Z., Liu, B., Hou, D., Liang, Y., Zhang, J., & Shi, P. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-669 · Cited by 234 · see citing works
Alterations of the Gut Microbiota in Hashimoto's Thyroiditis Patients
Zhao, F., Feng, J., Li, J., Zhao, L., Liu, Y., Chen, H., Jin, Y., Zhu, B., & Wei, Y. (2018) · Thyroid · doi:10.1089/thy.2017.0395 · Cited by 217 · see citing works
Mucosal microbiota of intestinal polyps reveals putative biomarkers of colorectal cancer
Mangifesta, M., Mancabelli, L., Milani, C., Gaiani, F., de’Angelis, N., de’Angelis, G. L., van Sinderen, D., Ventura, M., & Turroni, F. (2018) · Scientific Reports · doi:10.1038/s41598-018-32413-2 · Cited by 211 · see citing works
Large-Scale Survey of Gut Microbiota Associated With MHE Via 16S rRNA-Based Pyrosequencing
Zhang, Z., Zhai, H., Geng, J., Yu, R., Ren, H.-Q., Fan, H., & Shi, P. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.221 · Cited by 188 · see citing works
The Pathogenesis of Biliary Atresia: Evidence for a Virus-Induced Autoimmune Disease
Mack, C. L. (2007) · Seminars in Liver Disease · doi:10.1055/s-2007-985068 · Cited by 183 · see citing works
Interactions between the intestinal microbiota and bile acids in gallstones patients
Keren, N., Konikoff, F. M., Paitan, Y., Gabay, G., Reshef, L., Naftali, T., & Gophna, U. (2015) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12319 · Cited by 177 · see citing works
Etiopathogenesis of Biliary Atresia
Sokol, R. J., & Mack, C. L. (2001) · Seminars in Liver Disease · doi:10.1055/s-2001-19032 · Cited by 162 · see citing works
Significance of Streptococcus gallolyticus subsp. gallolyticus Association With Colorectal Cancer
Pasquereau-Kotula, E., Martins, M., Aymeric, L., & Dramsi, S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00614 · Cited by 155 · see citing works
Database Resources of the BIG Data Center in 2019
Zhang, Z., Zhao, W., Xiao, J., Bào, Y., Wang, F., Hao, L., Zhu, J., Chen, T., Zhang, S., Chen, X., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky993 · Cited by 140 · see citing works
Self-citationBauer, P. V., Duca, F. A., Waise, T. M. Z., Dranse, H. J., Rasmussen, B. A., Puri, A., Rasti, M., O'Brien, C. A., & Lam, T. K. T. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.013 · Cited by 104 · see citing works
Co-occurrence of driver and passenger bacteria in human colorectal cancer
Geng, J., Song, Q., Tang, X., Xiao, L., Fan, H., Peng, H., Guo, Q., & Zhang, Z. (2014) · Gut Pathogens · doi:10.1186/1757-4749-6-26 · Cited by 89 · see citing works
Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome
Hollister, E. B., Oezguen, N., Chumpitazi, B. P., Luna, R. A., Weidler, E. M., Rubio-Gonzales, M., Dahdouli, M., Cope, J. L., Mistretta, T., Raza, S., et al. (2019) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2019.01.006 · Cited by 89 · see citing works
Editorial Genetics, Immunology, and Biliary Atresia
Schreiber, R. A., & Kleinman, R. E. (1993) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199302000-00001 · Cited by 82 · see citing works
Mittal, V., Saxena, A. K., Sodhi, K. S., Thapa, B. R., Rao, K. L. N., Das, A. K., & Khandelwal, N. K. (2011) · American Journal of Roentgenology · doi:10.2214/ajr.10.5180 · Cited by 81 · see citing works
Potential etiologies of biliary atresia
Bezerra, J. A. (2005) · Pediatric Transplantation · doi:10.1111/j.1399-3046.2005.00350.x · Cited by 81 · see citing works
Fecal Biomarkers of Intestinal Health and Disease in Children
Pang, T., Leach, S. T., Katz, T. E., Day, A. S., & Ooi, C. Y. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00006 · Cited by 76 · see citing works
Chand, D., Panigrahi, P., Varshney, N. K., Ramasamy, S., & Suresh, C. G. (2018) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2018.01.003 · Cited by 64 · see citing works
Association of serum bilirubin in newborns affected by jaundice with gut microbiota dysbiosis
Zhou, S., Wang, Z., He, F., Qiu, H., Wang, Y., Wang, H., Zhou, J., Zhou, J., Cheng, G., Zhou, W., et al. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.09.016 · Cited by 61 · see citing works
Self-citationMetabolomics in the Clinical Diagnosis of Inflammatory Bowel Disease
Preter, V. D. (2015) · Digestive Diseases · doi:10.1159/000437033 · Cited by 50 · see citing works
Alterations of Gut Microbiota in Cholestatic Infants and Their Correlation With Hepatic Function
Guo, C., Li, Y., Wang, P., Li, Y., Qiu, C., Li, M., Wang, D., Zhao, R., Li, D., Wang, Y., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02682 · Cited by 50 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- [35]Wu T Gut microbiota dysbiosis and bacterial community assembly associated with cholesterol gallstones in large-scale study BMC genomics 2013 14 669 10.1186/1471-2164-14-669 24083370 PMC3851472 · DOI · Paper page
- [37]Guo, C. et al. Alterations of Gut Microbiota in Cholestatic Infants and Their Correlation With Hepatic Function. Frontiers in microbiology 9, 10.3389/fmicb.2018.02682 (2018). PMC6243132 30483228 · DOI
Cited by
Sorted by citations
Roles of intestinal Parabacteroides in human health and diseases
Cui, Y., Zhang, L., Wang, X., Yi, Y., Shan, Y., Liu, B., Zhou, Y., & Lü, X. (2022) · FEMS Microbiology Letters · doi:10.1093/femsle/fnac072 · Cited by 433 · see citing works
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
Zhao, Q., Dai, M., Huang, R., Duan, J., Zhang, T., Bao, W.-M., Zhang, J.-Y., Gui, S.-Q., Xia, S.-M., Dai, C.-T., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37459-z · Cited by 213 · see citing works
Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome
Hollister, E. B., Oezguen, N., Chumpitazi, B. P., Luna, R. A., Weidler, E. M., Rubio-Gonzales, M., Dahdouli, M., Cope, J. L., Mistretta, T., Raza, S., et al. (2019) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2019.01.006 · Cited by 89 · see citing works
Molecular Mechanisms of Microbiota-Mediated Pathology in Irritable Bowel Syndrome
Mishima, Y., & Ishihara, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228664 · Cited by 89 · see citing works
Xiang, D., Yang, J., Liu, L., Yu, H., Gong, X., & Liu, D. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115606 · Cited by 50 · see citing works
Therapeutic potential of Parabacteroides distasonis in gastrointestinal and hepatic disease
Duan, J., Li, Q., Cheng, Y., Zhu, W., Liu, H., & Li, F. (2024) · MedComm · doi:10.1002/mco2.70017 · Cited by 36 · see citing works
Metaflammation’s Role in Systemic Dysfunction in Obesity: A Comprehensive Review
Crasan, I.-M., Tanase, M., Delia, C., Pîrcălăbioru, G. G., Cîmpean, A., & Ionica, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110445 · Cited by 39 · see citing works
The role played by bacterial infections in the onset and metastasis of cancer
Khatun, S., Appidi, T., & Rengan, A. K. (2021) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2021.100078 · Cited by 33 · see citing works
Loisios-Konstantinidis, I., & Dressman, J. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00903 · Cited by 30 · see citing works
Antioxidative Molecules in Human Milk and Environmental Contaminants
Lorenzetti, S., Plösch, T., & Teller, I. C. (2021) · Antioxidants · doi:10.3390/antiox10040550 · Cited by 30 · see citing works
Gut feelings: the microbiota-gut-brain axis on steroids
So, S. Y., & Savidge, T. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00294.2021 · Cited by 29 · see citing works
Cossiga, V., Lembo, V., Nigro, C., Mirra, P., Miele, C., D’Argenio, V., Leone, A., Mazzone, G., Veneruso, I., Guido, M., et al. (2021) · Nutrients · doi:10.3390/nu13041281 · Cited by 27 · see citing works
Chronic Arsenic Exposure Perturbs Gut Microbiota and Bile Acid Homeostasis in Mice
Yang, Y., Chi, L., Liu, C., Hsiao, Y.-C., & Lü, K. (2023) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.2c00410 · Cited by 22 · see citing works
Self-citationIshizaka, A., Koga, M., Mizutani, T., Lim, L. A., Adachi, E., Ikeuchi, K., Ueda, R., Aoyagi, H., Tanaka, S., Kiyono, H., et al. (2021) · Viruses · doi:10.3390/v13102101 · Cited by 22 · see citing works
Kiriyama, Y., & Nochi, H. (2023) · Genes · doi:10.3390/genes14040825 · Cited by 22 · see citing works
Bile Acids: Physiological Activity and Perspectives of Using in Clinical and Laboratory Diagnostics
Shansky, Y. D., & Bespyatykh, J. (2022) · Molecules · doi:10.3390/molecules27227830 · Cited by 21 · see citing works
Zhai, Y., Fu, S., Zhang, R.-Y., Yin, C., Zhou, H., Zhang, J., & Gao, C. (2019) · Journal of Optics · doi:10.1088/2040-8986/ab146f · Cited by 20 · see citing works
Circulating neutrophil anti-pathogen dysfunction in cirrhosis
Balázs, I., & Stadlbauer, V. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100871 · Cited by 19 · see citing works
Abdo, A. A. A., Zhang, C., Lin, Y., Liang, X., Kaddour, B., Wu, Q., Li, X., Fan, G., Yang, R., Teng, C., et al. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104334 · Cited by 17 · see citing works
Park, S. M., & Rhee, M. S. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.104984 · Cited by 13 · see citing works
Hernandez, J. B., Hayer, S. S., Alvarez, S., Fischer, A., Hassenstab, H. R., Cooper, K., Alsafwani, Z. W., Benson, A. K., Haute, M. J. S. V., Izard, J., et al. (2025) · mSystems · doi:10.1128/msystems.00214-25 · Cited by 13 · see citing works
Gut microbiome-based machine learning model for early colorectal cancer and adenoma screening
Tsai, Y.-J., Lyu, W.-N., Liao, N.-S., Chen, P., Tsai, M., & Chuang, E. Y.-Y. (2025) · Gut Pathogens · doi:10.1186/s13099-025-00750-z · Cited by 13 · see citing works
Ma, X., Wen, G., Zhao, Z. Y., Lu, L., Li, T., Gao, N., & Han, G. (2024) · Scientific Reports · doi:10.1038/s41598-024-58983-y · Cited by 12 · see citing works
Karandikar, K., Bhonde, G., Palav, H. C., Padwal, V., Velhal, S., Pereira, J., Meshram, H., Goel, A., Shah, I., Patel, V. V., et al. (2023) · Microbes and Infection · doi:10.1016/j.micinf.2023.105165 · Cited by 11 · see citing works
Liu, Y., Zhang, Y., Guo, C., Li, M., Wang, Y., & Zhang, L. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1402329 · Cited by 9 · see citing works
Self-citationIlott, N. E., Neyazi, M., Oxford Translational Gastroenterology Unit Investigators, Arancibia-Cárcamo, C. V., Powrie, F. M., & Geremia, A. (2021) · Wellcome Open Research · doi:10.12688/wellcomeopenres.16901.1 · Cited by 5 · see citing works
Tan, Z., Yang, C., Zhao, Y., Yang, X.-B., & Li, T. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c04034 · Cited by 6 · see citing works
Gut microbial bile salt hydrolase as a metabolic gatekeeper in digestive homeostasis and disease
Chu, H., Song, X., Liu, C., Ma, T., & Cui, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1870619 · Cited by 5 · see citing works
Self-citationHussan, H., Ali, M. R., Lyo, V., Webb, A., Pietrzak, M., Zhu, J., Choueiry, F., Li, H., Cummings, B. P., Marco, M. L., et al. (2024) · Obesity Surgery · doi:10.1007/s11695-024-07420-0 · Cited by 4 · see citing works
He, Q., Hong-ji, W., Guo, M., Ye, R., Li, H., & Zhang, Q. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112455 · Cited by 3 · see citing works
He, S., Li, Z., Li, J., & Li, Y. (2025) · Microbiology · doi:10.1099/mic.0.001608 · Cited by 2 · see citing works
Santos, A. A., Pires, D., Marques, V., Alesina, N., Rodrigues, P. M., Bravo, A. C., Gouveia, C., Saraiva, S., Correia, L., Crespo, R., et al. (2025) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2025.105013 · Cited by 2 · see citing works
Li, Y., Chen, Y., Huang, X., Yang, J., Zhou, Z., Ma, X., & Zeng, L. (2026) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2026.2709189 · Cited by 2 · see citing works
Ilott, N. E., Neyazi, M., Oxford Translational Gastroenterology Unit Investigators, Arancibia-Cárcamo, C. V., Powrie, F. M., & Geremia, A. (2022) · Wellcome Open Research · doi:10.12688/wellcomeopenres.16901.2 · Cited by 1 · see citing works
Gore, R., Mohsenipour, M., Wood, J. L., Balasuriya, G. K., Hill‐Yardin, E. L., & Franks, A. E. (2023) · Infection and Immunity · doi:10.1128/iai.00097-23 · Cited by 1 · see citing works
Ziegler, A., Sæves, I., & Almaas, R. (2024) · Clinica Chimica Acta · doi:10.1016/j.cca.2024.119864 · Cited by 1 · see citing works
Formononetin: a promising therapeutic agent targeting the gut-lung axis in acute lung injury
Batu, W., Liu, D., Ren, C., Bi, W., Wang, J., & Wang, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1761248 · Cited by 1 · see citing works
吴, 忠. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1422365
Changes in the Gut Microbiota of Neonates with Hyperbilirubinemia Reaching Phototherapy Thresholds
Yu, Q., Lu, T., Yan, J., Shen, N., Wu, R., Liu, S., Zhang, Z., & Zhu, S. (2025) · International Journal of General Medicine · doi:10.2147/ijgm.s531481
Self-citation
- Authors
- Li, M., Liu, S., Wang, M., Hu, H., Yin, J., Liu, C., & Huang, Y.
- Affiliations
- The First Hospital of Kunming (CN)
- Kunming Medical University (CN)
- Yunnan Center for Disease Control And Prevention (CN)
- Kunming Institute of Zoology (CN)
- Corresponding author
- Liu, Chuanfa
- Huang, Yongkun
- Venue
- Scientific Reports
- Published
- 2020-05-06
- Volume
- 10
- Issue
- 1
- Pages
- 7686-7686
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC7203226
- OpenAlex
- W3021965178
- Cited by
- 41
- References
- 46
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 8 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 2
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- neonatal cholestasis, gut dysbiosis, bile acid metabolism, secondary bile acids, short-chain fatty acids, Streptococcus bovis, Parabacteroides distasonis, Lactobacillus gasseri, fecal microbiota, non-invasive biomarkers, early diagnosis, bile secretion
- MeSH terms
- Gastrointestinal Microbiome, Bile Acids and Salts, Cholestasis, Disease Susceptibility, Feces, Humans, Infant, Infant, Newborn, Liver, Liver Function Tests, Prognosis, Biomarkers, Metagenome, Metagenomics, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
