Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life
Open accessAbstract
Bacterial community acquisition in the infant gut impacts immune education and disease susceptibility. We compared bacterial strains across and within families in a prospective birth cohort of 44 infants and their mothers, sampled longitudinally in the first months of each child's life. We identified mother-to-child bacterial transmission events and describe the incidence of family-specific antibiotic resistance genes. We observed two inheritance patterns across multiple species, where often the mother's dominant strain is transmitted to the child, but occasionally her secondary strains colonize the infant gut. In families where the secondary strain of B. uniformis was inherited, a starch utilization gene cluster that was absent in the mother's dominant strain was identified in the child, suggesting the selective advantage of a mother's secondary strain in the infant gut. Our findings reveal mother-to-child bacterial transmission events at high resolution and give insights into early colonization of the infant gut.
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It is unlikely that infants acquire many of such species directly from food consumption since maternal transmission is the most probable route of acquisition.
“Although it is unlikely that infants acquire many of such species directly from food consumption since maternal transmission is the most probable route of acquisition, 103-105”
From Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome. (2024) · cites this paper as [103]
The Discussion (page not provided) reports evidence of mother-to-child transmission for several shared bacterial species and says acquisition from a shared environmental source likely accounts for a minority of the transmission events studied. It does not assess acquisition directly from food or establish maternal transmission as the most probable route for the broader group of species in the citing claim. (LLM, conf=0.84)
Experimental — accuracy not yet measuredEscherichia coli and Bifidobacterium species (B. uniformis, B. bifidum, B. breve, B. catenulatum) have been found to be highly transmitted from mother to child in several studies.
“that have been found to be highly transmitted from mother to child in several studies10,15,16,17,41 and that are also present but not shared in pairs from non-westernized populations (Figure 2C).”
From Maternal and food microbial sources shape the infant microbiome of a rural Ethiopian population (2023) · cites this paper as [17]
Escherichia coli and Bifidobacterium spp. are the most shared within European mother-infant pairs.
“While Escherichia coli and Bifidobacterium spp. are the most shared within the European pairs, as previously described,10,15,16,17,41”
From Maternal and food microbial sources shape the infant microbiome of a rural Ethiopian population (2023) · cites this paper as [17]
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- Authors
- Yassour, M., Jason, E., Hogstrom, L. J., Arthur, T. D., Tripathi, S., Siljander, H., Selvenius, J., Oikarinen, S., Hyöty, H., Virtanen, S. M., Ilonen, J., Ferretti, P., Pasolli, E., Tett, A., Asnicar, F., Segata, N., Vlamakis, H., Lander, E. S., Huttenhower, C., Knip, M., & Xavier, R. J.
- Affiliations
- Broad Institute (US)
- Tampere University Hospital (FI)
- University of Helsinki (FI)
- Tampere University (FI)
- University of Turku (FI)
- University of Trento (IT)
- Corresponding author
- Yassour, Moran
- Xavier, Ramnik J.
- ORCID
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 24
- Issue
- 1
- Pages
- 146-154.e4
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC6091882
- OpenAlex
- W2821623253
- Cited by
- 455
- References
- 35
- Citations by year
- 2026: 28 · 2025: 54 · 2024: 65 · 2023: 62 · 2022: 55 · 2021: 74 · 2020: 74 · 2019: 30 · 2018: 11
- FWCI
- 17.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Iris (University of Trento) (submittedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Funders
- National Institutes of Health (1DP3DK094338-01)
- Juvenile Diabetes Research Foundation in Israel (2-SRA-2016-247-S-B)
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- infant gut microbiota, strain-level analysis, antibiotic resistance genes, Bacteroides uniformis
- MeSH terms
- Gastrointestinal Microbiome, Adult, Bacteroides, DNA, Bacterial, Feces, Female, Humans, Infant, Infant, Newborn, Longitudinal Studies, Male, Meconium, Mother-Child Relations, Prospective Studies, Cohort Studies, Drug Resistance, Bacterial, Metagenomics
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