The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Cell Atlas of The Human Fovea and Peripheral Retina
Open accessPublished version of a preprint
Abstract
Most irreversible blindness results from retinal disease. To advance our understanding of the etiology of blinding diseases, we used single-cell RNA-sequencing (scRNA-seq) to analyze the transcriptomes of ~85,000 cells from the fovea and peripheral retina of seven adult human donors. Utilizing computational methods, we identified 58 cell types within 6 classes: photoreceptor, horizontal, bipolar, amacrine, retinal ganglion and non-neuronal cells. Nearly all types are shared between the two retinal regions, but there are notable differences in gene expression and proportions between foveal and peripheral cohorts of shared types. We then used the human retinal atlas to map expression of 636 genes implicated as causes of or risk factors for blinding diseases. Many are expressed in striking cell class-, type-, or region-specific patterns. Finally, we compared gene expression signatures of cell types between human and the cynomolgus macaque monkey, Macaca fascicularis . We show that over 90% of human types correspond transcriptomically to those previously identified in macaque, and that expression of disease-related genes is largely conserved between the two species. These results validate the use of the macaque for modeling blinding disease, and provide a foundation for investigating molecular mechanisms underlying visual processing.
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Cited by
Solving neurodegeneration: common mechanisms and strategies for new treatments
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Metadata
- Authors
- Yan, W., Peng, Y.-R., van Zyl, T., Regev, A., Shekhar, K., Juric, D., & Sanes, J. R.
- Venue
- Scientific Reports
- Published
- 2020-06-17
- Volume
- 10
- Issue
- 1
- Pages
- 9802-9802
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W3036431915
- Cited by
- 283
- References
- 69
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- gold
- Licence
- creativecommons.org/licenses/by/4.0 (tdm)
- creativecommons.org/licenses/by/4.0 (vor)
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- Yan, W., Peng, Y.-R., van Zyl, T., Regev, A., Shekhar, K., Juric, D., & Sanes, J. R. (2020). Cell Atlas of The Human Fovea and Peripheral Retina. Scientific Reports. https://doi.org/10.1038/s41598-020-66092-9
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