Intrinsically photosensitive retinal ganglion cells of the human retina
Open accessAbstract
Light profoundly affects our mental and physical health. In particular, light, when not delivered at the appropriate time, may have detrimental effects. In mammals, light is perceived not only by rods and cones but also by a subset of retinal ganglion cells that express the photopigment melanopsin that renders them intrinsically photosensitive (ipRGCs). ipRGCs participate in contrast detection and play critical roles in non-image-forming vision, a set of light responses that include circadian entrainment, pupillary light reflex (PLR), and the modulation of sleep/alertness, and mood. ipRGCs are also found in the human retina, and their response to light has been characterized indirectly through the suppression of nocturnal melatonin and PLR. However, until recently, human ipRGCs had rarely been investigated directly. This gap is progressively being filled as, over the last years, an increasing number of studies provided descriptions of their morphology, responses to light, and gene expression. Here, I review the progress in our knowledge of human ipRGCs, in particular, the different morphological and functional subtypes described so far and how they match the murine subtypes. I also highlight questions that remain to be addressed. Investigating ipRGCs is critical as these few cells play a major role in our well-being. Additionally, as ipRGCs display increased vulnerability or resilience to certain disorders compared to conventional RGCs, a deeper knowledge of their function could help identify therapeutic approaches or develop diagnostic tools. Overall, a better understanding of how light is perceived by the human eye will help deliver precise light usage recommendations and implement light-based therapeutic interventions to improve cognitive performance, mood, and life quality.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
When light enters the eye, it is detected by intrinsically photosensitive retinal ganglion cells, which then send signals to the suprachiasmatic nuclei in the hypothalamus, the brain's master clock that coordinates daily physiological rhythms.
“When light enters the eye, it is detected by intrinsically photosensitive retinal ganglion cells, which then send signals to the suprachiasmatic nuclei in the hypothalamus, the brain's master clock that coordinates daily physiological rhythms [60].”
From Ocular light exposure interventions for sleep, circadian rhythms, rest-activity cycles, mood, and cognitive function in older adults: An Overview of Cochrane and non-Cochrane Systematic Reviews (2025) · cites this paper as [60]
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredThe mechanism behind ocular light exposure interventions lies in the non-image-forming effects of light, mediated by specialised, intrinsically photosensitive retinal ganglion cell photoreceptors in the eye.
“The mechanism behind ocular light exposure interventions lies in the non‐image‐forming effects of light, mediated by specialised, intrinsically photosensitive retinal ganglion cell photoreceptors in the eye [60].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629 · see citing works
Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor
Brainard, G. C., Hanifin, J. P., Greeson, J. M., Byrne, B., Glickman, G., Gerner, E., & Rollag, M. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06405.2001 · Cited by 1,930 · see citing works
Topography of ganglion cells in human retina
Curcio, C. A., & Allen, K. A. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903000103 · Cited by 1,849 · see citing works
Chang, A.-M., Aeschbach, D., Duffy, J. F., & Czeisler, C. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418490112 · Cited by 1,430 · cited 1× · see citing works
“Even low-level light exposure from light-emitting devices, smartphones, or tablets may disrupt sleep (5, 6).”
BackgroundDacey, D. M., Liao, H.-W., Peterson, B. B., Robinson, F. R., Smith, V. C., Pokorny, J., Yau, K.-W., & Gamlin, P. D. (2005) · Nature · doi:10.1038/nature03387 · Cited by 1,333 · see citing works
Thapan, K., Arendt, J., & Skene, D. J. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.t01-1-00261.x · Cited by 1,320 · see citing works
A Novel Human Opsin in the Inner Retina
Provencio, I., Rodriguez, I. R., Jiang, G., Hayes, W. P., Moreira, E. F., & Rollag, M. D. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00600.2000 · Cited by 1,290 · see citing works
Central projections of melanopsin‐expressing retinal ganglion cells in the mouse
Hattar, S., Kumar, M., Park, A., Tong, P., Tung, J., Yau, K., & Berson, D. M. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20970 · Cited by 996 · see citing works
Melanopsin: An opsin in melanophores, brain, and eye
Provencio, I., Jiang, G., De Grip, W. J., Hayes, W. P., & Rollag, M. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.340 · Cited by 975 · see citing works
Artificially lit surface of Earth at night increasing in radiance and extent
Kyba, C. C. M., Kuester, T., de Miguel, A. S., Baugh, K., Jechow, A., Hölker, F., Bennie, J., Elvidge, C. D., Gaston, K. J., & Guanter, L. (2017) · Science Advances · doi:10.1126/sciadv.1701528 · Cited by 958 · see citing works
Cajochen, C., Münch, M., Kobialka, S., Kräuchi, K., Steiner, R., Oelhafen, P., Orgül, S., & Wirz-Justice, A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0957 · Cited by 939 · see citing works
Riemersma-van der Lek, R. F. (2008) · JAMA · doi:10.1001/jama.299.22.2642 · Cited by 803 · see citing works
Ecker, J. L., Dumitrescu, O. N., Wong, K. Y., Alam, N. M., Chen, S., LeGates, T. A., Renna, J. M., Prusky, G. T., Berson, D. M., & Hattar, S. S. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.023 · Cited by 669 · see citing works
Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution
Cowan, C. S., Renner, M., De Gennaro, M., Gross-Scherf, B., Goldblum, D., Hou, Y., Munz, M., Rodrigues, T. M., Krol, J., Szikra, T., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.013 · Cited by 654 · see citing works
Tran, N. M., Shekhar, K., Whitney, I. E., Jacobi, A., Benhar, I., Hong, G., Yan, W., Adiconis, X., Arnold, M. E., Lee, J. M., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.11.006 · Cited by 627 · see citing works
Human and macaque pupil responses driven by melanopsin-containing retinal ganglion cells
Gamlin, P. D. R., McDougal, D. H., Pokorny, J., Smith, V. C., Yau, K.-W., & Dacey, D. M. (2007) · Vision Research · doi:10.1016/j.visres.2006.12.015 · Cited by 617 · see citing works
Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq
Cadwell, C. R., Palasantza, A., Jiang, X., Berens, P., Deng, Q., Yilmaz, M., Reimer, J., Shen, S., Bethge, M., Tolias, K. F., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3445 · Cited by 581 · see citing works
Applebury, M. L., Antoch, M. P., Baxter, L. C., Chun, L. L. Y., Falk, J. D., Farhangfar, F., Kage, K., Krzystolik, M. G., Lyass, L., & Robbins, J. T. (2000) · Neuron · doi:10.1016/s0896-6273(00)00062-3 · Cited by 566 · see citing works
Viola, A. U., James, L. M., Schlangen, L. J., & Dijk, D.-J. (2008) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.1268 · Cited by 565 · see citing works
Light Affects Mood and Learning through Distinct Retina-Brain Pathways
Fernandez, D. C., Fogerson, P. M., Lazzerini Ospri, L., Thomsen, M. B., Layne, R. M., Severin, D., Zhan, J., Singer, J. H., Kirkwood, A., Zhao, H., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.004 · Cited by 505 · see citing works
Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate Retina
Peng, Y., Shekhar, K., Yan, W., Herrmann, D., Sappington, A., Bryman, G. S., van Zyl, T. A., Do, M. T. H., Regev, A., & Sanes, J. R. (2019) · Cell · doi:10.1016/j.cell.2019.01.004 · Cited by 465 · see citing works
Gooley, J. J., Rajaratnam, S. M. W., Brainard, G. C., Kronauer, R. E., Czeisler, C. A., & Lockley, S. W. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000741 · Cited by 447 · see citing works
Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs
Chen, S., Badea, T. C., & Hattar, S. S. (2011) · Nature · doi:10.1038/nature10206 · Cited by 436 · see citing works
Phillips, A. J. K., Vidafar, P., Burns, A. C., McGlashan, E. M., Anderson, C., Rajaratnam, S. M. W., Lockley, S. W., & Cain, S. W. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901824116 · Cited by 430 · see citing works
Retinal receptors in rodents maximally sensitive to ultraviolet light
Jacobs, G. H., Neitz, J., & Deegan, J. F. (1991) · Nature · doi:10.1038/353655a0 · Cited by 415 · see citing works
Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes
Rheaume, B. A., Jereen, A., Bolisetty, M. T., Sajid, M. S., Yang, Y. J., Renna, K., Sun, L., Robson, P., & Trakhtenberg, E. F. (2018) · Nature Communications · doi:10.1038/s41467-018-05134-3 · Cited by 401 · see citing works
Animal models of age related macular degeneration
Pennesi, M. E., Neuringer, M., & Courtney, R. J. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.06.003 · Cited by 391 · see citing works
Melanopsin retinal ganglion cell loss in A lzheimer disease
Morgia, C. L., Ross‐Cisneros, F. N., Koronyo, Y., Hannibal, J., Gallassi, R., Cantalupo, G., Sambati, L., Pan, B. X., Tozer, K. R., Barboni, P., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24548 · Cited by 389 · see citing works
Zaidi, F. H., Hull, J. T., Peirson, S. N., Wulff, K., Aeschbach, D., Gooley, J. J., Brainard, G. C., Gregory-Evans, K., Rizzo, J. F., Czeisler, C. A., et al. (2007) · Current Biology · doi:10.1016/j.cub.2007.11.034 · Cited by 364 · see citing works
Spectral sensitivity of human cone photoreceptors
Schnapf, J. L., Kraft, T. W., & Baylor, D. A. (1987) · Nature · doi:10.1038/325439a0 · Cited by 342 · see citing works
Bailes, H. J., & Lucas, R. J. (2013) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2012.2987 · Cited by 319 · cited 1× · see citing works
“Their spectral sensitivity peaked in the blue region of the spectrum (∼460 nm), different from the peaks of human rods and cones but close to mouse andmacaquemelanopsin peaks (17, 34) and to the human melanopsin expressed in HEK293 cells (61).”
BackgroundMelanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior
Do, M. T. H. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.016 · Cited by 305 · see citing works
Nikonov, S. S., Kholodenko, R. V., Lem, J., & Pugh, E. N. (2006) · The Journal of General Physiology · doi:10.1085/jgp.200609490 · Cited by 298 · see citing works
Touitou, Y., Touitou, D., & Reinberg, A. (2016) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2017.05.001 · Cited by 297 · see citing works
Cell Atlas of The Human Fovea and Peripheral Retina
Yan, W., Peng, Y., van Zyl, T. A., Regev, A., Shekhar, K., Juric, D., & Sanes, J. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-66092-9 · Cited by 286 · see citing works
Age‐related Changes in the Circadian and Homeostatic Regulation of Human Sleep
Cajochen, C., Münch, M., Knoblauch, V., Blatter, K., & Wirz‐Justice, A. (2006) · Chronobiology International · doi:10.1080/07420520500545813 · Cited by 285 · see citing works
Vandewalle, G., Gais, S., Schabus, M., Balteau, E., Carrier, J., Darsaud, A., Sterpenich, V., Albouy, G., Dijk, D. J., & Maquet, P. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm007 · Cited by 277 · see citing works
Synaptic influences on rat ganglion‐cell photoreceptors
Wong, K. Y., Dunn, F. A., Graham, D. M., & Berson, D. M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.133751 · Cited by 265 · see citing works
Melanopsin Contributions to Irradiance Coding in the Thalamo-Cortical Visual System
Brown, T. M., Gias, C., Hatori, M., Keding, S. R., Semo, M., Coffey, P. J., Gigg, J., Piggins, H. D., Panda, S., & Lucas, R. J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000558 · Cited by 259 · see citing works
Melanopsin-Based Brightness Discrimination in Mice and Humans
Brown, T. M., Tsujimura, S.-I., Allen, A. E., Wynne, J., Bedford, R., Vickery, G., Vugler, A., & Lucas, R. J. (2012) · Current Biology · doi:10.1016/j.cub.2012.04.039 · Cited by 256 · see citing works
Brown, T. M. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12655 · Cited by 240 · see citing works
Physiologic Diversity and Development of Intrinsically Photosensitive Retinal Ganglion Cells
Tu, D. C., Zhang, D., Demas, J., Slutsky, E. B., Provencio, I., Holy, T. E., & Gelder, R. N. V. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.031 · Cited by 236 · see citing works
Functional and Morphological Differences among Intrinsically Photosensitive Retinal Ganglion Cells
Schmidt, T. M., & Kofuji, P. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4117-08.2009 · Cited by 233 · see citing works
Biology and therapy of inherited retinal degenerative disease: insights from mouse models
Veleri, S., Lazar, C. H., Chang, B., Sieving, P. A., Banin, E., & Swaroop, A. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.017913 · Cited by 232 · see citing works
Stabio, M. E., Fogerson, P. M., Ilardi, M. C., Borghuis, B. G., Chan, E., Weng, S.-J., Auferkorte, O. N., Demb, J. B., & Berson, D. M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1422-12.2012 · Cited by 229 · see citing works
Paksarian, D., Rudolph, K. E., Stapp, E. K., Dunster, G. P., He, J., Mennitt, D. J., Hattar, S. S., Casey, J. A., James, P., & Merikangas, K. R. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.1935 · Cited by 227 · see citing works
Hannibal, J., Hindersson, P., Østergaard, J., Georg, B., Heegaard, S., Larsen, P. J., & Fahrenkrug, J. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0313 · Cited by 213 · see citing works
Figueiro, M., Plitnick, B., Lok, A., Jones, G., Higgins, P., Hornick, T., & Rea, M. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s68557 · Cited by 211 · see citing works
Opponent melanopsin and S-cone signals in the human pupillary light response
Spitschan, M., Jain, S., Brainard, D. H., & Aguirre, G. K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400942111 · Cited by 192 · see citing works
Morgia, C. L., Ross‐Cisneros, F. N., Sadun, A. A., Hannibal, J., Munarini, A., Mantovani, V., Barboni, P., Cantalupo, G., Tozer, K. R., Sancisi, E., et al. (2010) · Brain · doi:10.1093/brain/awq155 · Cited by 191 · see citing works
Melanopsin Bistability: A Fly's Eye Technology in the Human Retina
Mure, L. S., Cornut, P., Rieux, C., Drouyer, E., Denis, P., Gronfier, C., & Cooper, H. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005991 · Cited by 175 · see citing works
Self-citationPhotoresponse diversity among the five types of intrinsically photosensitive retinal ganglion cells
Zhao, X., Stafford, B. K., Godin, A. L., King, W. M., & Wong, K. Y. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.262782 · Cited by 174 · see citing works
Hannibal, J., Christiansen, A. T., Heegaard, S., Fahrenkrug, J., & Kiilgaard, J. F. (2017) · Journal of Comparative Neurology · doi:10.1002/cne.24181 · Cited by 169 · see citing works
Visual transduction in human rod photoreceptors.
Kraft, T. W., Schneeweis, D. M., & Schnapf, J. L. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019661 · Cited by 165 · see citing works
Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions
Aranda, M. L., & Schmidt, T. M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03641-5 · Cited by 164 · see citing works
Circadian Photoentrainment in Mice and Humans
Foster, F., Hughes, S., & Peirson, S. N. (2020) · Biology · doi:10.3390/biology9070180 · Cited by 163 · see citing works
Individual differences in light sensitivity affect sleep and circadian rhythms
Chellappa, S. L. (2021) · Sleep · doi:10.1093/sleep/zsaa214 · Cited by 163 · see citing works
Bardy, C., van den Hurk, M., Kakaradov, B., Erwin, J. A., Jaeger, B. N., Hernandez, R. V., Eames, T., Paucar, A. A., Gorris, M. A. J., Marchand, C., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.158 · Cited by 160 · see citing works
Sleep fragmentation in patients from a nursing home
Ancoli-Israel, S., Parker, L., Sinaee, R., Fell, R. L., & Kripke, D. F. (1989) · Journal of Gerontology · doi:10.1093/geronj/44.1.m18 · Cited by 157 · cited 1× · see citing works
“However, there are also reports of reduced amplitude of circadian rhythm in body temperature and increasing prevalence of sleep fragmentation among the elderly (95, 96), which can be improved by bright light (8).”
BackgroundCentral projections of intrinsically photosensitive retinal ganglion cells in the macaque monkey
Hannibal, J., Kankipati, L., Strang, C. E., Peterson, B. B., Dacey, D. M., & Gamlin, P. D. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23555 · Cited by 153 · see citing works
Liao, H., Ren, X., Peterson, B. B., MARSHAK, D. W., Yau, K., Gamlin, P. D., & Dacey, D. M. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.23995 · Cited by 153 · see citing works
Schmidt, T. M., & Kofuji, P. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22579 · Cited by 126 · see citing works
Functional diversity of human intrinsically photosensitive retinal ganglion cells
Mure, L. S., Vinberg, F., Hanneken, A. M., & Panda, S. (2019) · Science · doi:10.1126/science.aaz0898 · Cited by 124 · see citing works
Self-citationLight-Induced Pupillary Responses in Alzheimer's Disease
Chougule, P. S., Najjar, R. P., Finkelstein, M. T., Kandiah, N., & Miléa, D. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00360 · Cited by 117 · see citing works
Spitschan, M., Bock, A. S., Ryan, J., Frazzetta, G., Brainard, D. H., & Aguirre, G. K. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711522114 · Cited by 116 · see citing works
Synapses in neurodegenerative diseases
Bae, J. R., & Kim, S. H. (2017) · BMB Reports · doi:10.5483/bmbrep.2017.50.5.038 · Cited by 113 · see citing works
Retinal Ganglion Cells and Circadian Rhythms in Alzheimer’s Disease, Parkinson’s Disease, and Beyond
Morgia, C. L., Ross‐Cisneros, F. N., Sadun, A. A., & Carelli, V. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00162 · Cited by 111 · see citing works
Cui, Q., Ren, C., Sollars, P. J., Pickard, G. E., & So, K. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.11.002 · Cited by 110 · see citing works
Esquiva, G., Lax, P., Pérez-Santonja, J. J., García-Fernández, J. M., & Cuenca, N. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00079 · Cited by 106 · see citing works
Nasir‐Ahmad, S., Lee, S., Martin, P. R., & Grünert, U. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24176 · Cited by 105 · see citing works
Body Silhouette Trajectories Over the Lifespan and Insomnia Symptoms: The Paris Prospective Study 3
Lisan, Q., Tafflet, M., Thomas, F., Boutouyrie, P., Guibout, C., Haba‐Rubio, J., Climie, R. E., Perier, M., van Sloten, T. T., Pannier, B., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-38145-7 · Cited by 105 · see citing works
Form vision from melanopsin in humans
Allen, A. E., Martial, F. P., & Lucas, R. J. (2019) · Nature Communications · doi:10.1038/s41467-019-10113-3 · Cited by 104 · see citing works
Metabolic Implications of Exposure to Light at Night: Lessons from Animal and Human Studies
Fleury, G., Masís‐vargas, A., & Kalsbeek, A. (2020) · Obesity · doi:10.1002/oby.22807 · Cited by 100 · see citing works
Melanopsin-mediated pupil function is impaired in Parkinson’s disease
Joyce, D. S., Feigl, B., Kerr, G., Roeder, L., & Zele, A. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-26078-0 · Cited by 90 · see citing works
What is the ‘spectral diet’ of humans?
Webler, F. S., Spitschan, M., Foster, F., Andersen, M., & Peirson, S. N. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.06.006 · Cited by 90 · see citing works
Photoreceptor inputs to pupil control
Spitschan, M. (2019) · Journal of Vision · doi:10.1167/19.9.5 · Cited by 88 · see citing works
Ortuño‐Lizarán, I., Esquiva, G., Beach, T. G., Serrano, G. E., Adler, C. H., Lax, P., & Cuenca, N. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0596-z · Cited by 87 · see citing works
Melanopsin-expressing retinal ganglion cells: implications for human diseases
La Morgia, C., Ross-Cisneros, F. N., Hannibal, J., Montagna, P., Sadun, A. A., & Carelli, V. (2011) · Vision Research · doi:10.1016/j.visres.2010.07.023 · Cited by 84 · see citing works
Human retinohypothalamic tract as revealed by in vitro postmortem tracing
Dai, J., van der Vliet, J., Swaab, D. F., & Buijs, R. M. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980803)397:3 · Cited by 83 · see citing works
Adhikari, P., Pearson, C. A., Anderson, A. M., Zele, A. J., & Feigl, B. (2015) · Scientific Reports · doi:10.1038/srep17610 · Cited by 83 · see citing works
Gaston, K. J. (2018) · Science · doi:10.1126/science.aau8226 · Cited by 81 · see citing works
Small-molecule antagonists of melanopsin-mediated phototransduction
JONES, K. A., Hatori, M., Mure, L. S., Bramley, J. R., Artymyshyn, R. P., Hong, S.-P., Marzabadi, M. R., Zhong, H., Sprouse, J. S., Zhu, Q., et al. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1333 · Cited by 77 · see citing works
Self-citationThe rat retina has five types of ganglion-cell photoreceptors
Reifler, A. N., Chervenak, A. P., Dolikian, M. E., Benenati, B. A., Meyers, B. S., Demertzis, Z. D., Lynch, A. M., Li, B. Y., Wachter, R. D., Abufarha, F. S., et al. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.11.010 · Cited by 68 · see citing works
Molecular signatures of retinal ganglion cells revealed through single cell profiling
Laboissonniere, L. A., Goetz, J. J., Martin, G. M., Bi, R., Lund, T. J. S., Ellson, L., Lynch, M. R., Mooney, B., Wickham, H., Liu, P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-52215-4 · Cited by 68 · see citing works
Najjar, R. P., Sharma, S., Atalay, E., Rukmini, A. V., Sun, C., Lock, J. Z., Baskaran, M., Perera, S., Husain, R., Lamoureux, E. L., et al. (2018) · Ophthalmology · doi:10.1016/j.ophtha.2018.02.024 · Cited by 66 · see citing works
Melanopsin Retinal Ganglion Cells and Pupil: Clinical Implications for Neuro-Ophthalmology
Morgia, C. L., Carelli, V., & Carbonelli, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01047 · Cited by 66 · see citing works
Sondereker, K. B., Stabio, M. E., & Renna, J. M. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24873 · Cited by 63 · see citing works
Does Pupil Constriction under Blue and Green Monochromatic Light Exposure Change with Age?
Daneault, V., Vandewalle, G., Hébert, M., Teikari, P., Mure, L. S., Doyon, J., Gronfier, C., Cooper, H. M., Dumont, M., & Carrier, J. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730412441172 · Cited by 59 · see citing works
Self-citationLoss of Melanopsin-Expressing Retinal Ganglion Cells in Severely Staged Glaucoma Patients
Obara, E. A. A., Hannibal, J., Heegaard, S., & Fahrenkrug, J. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19997 · Cited by 59 · see citing works
Schroeder, M. M., Harrison, K. R., Jaeckel, E. R., Berger, H. N., Zhao, X., Flannery, M. P., Pierre, E. S., Pateqi, N., Jachimska, A., Chervenak, A. P., et al. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00203 · Cited by 55 · see citing works
Efficient Coding by Midget and Parasol Ganglion Cells in the Human Retina
Soto, F., Hsiang, J.-C., Rajagopal, R., Piggott, K., Harocopos, G. J., Couch, S. M., Custer, P. L., Morgan, J., & Kerschensteiner, D. (2020) · Neuron · doi:10.1016/j.neuron.2020.05.030 · Cited by 55 · see citing works
Delwig, A., Larsen, D. D., Yasumura, D., Yang, C. F., Shah, N. M., & Copenhagen, D. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149501 · Cited by 50 · see citing works
Lucas, R. J., Allen, A. E., Milosavljevic, N., Storchi, R., & Woelders, T. (2020) · Annual Review of Vision Science · doi:10.1146/annurev-vision-030320-041239 · Cited by 50 · see citing works
Loss of Melanopsin-Expressing Retinal Ganglion Cells in Patients With Diabetic Retinopathy
Obara, E. A. A., Hannibal, J., Heegaard, S., & Fahrenkrug, J. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-21168 · Cited by 49 · see citing works
Immunohistochemical Evidence of a Melanopsin Cone in Human Retina
Dkhissi‐Benyahya, O., Rieux, C., Hut, R. A., & Cooper, H. M. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1459 · Cited by 47 · see citing works
Visual properties of human retinal ganglion cells
Reinhard, K., & Münch, T. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246952 · Cited by 47 · see citing works
Oh, A. J., Amore, G., Sultan, W., Asanad, S., Park, J. C., Romagnoli, M., Morgia, C. L., Karanjia, R., Harrington, M. G., & Sadun, A. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226197 · Cited by 45 · see citing works
Lee, S. K., Sonoda, T., & Schmidt, T. M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.024 · Cited by 44 · see citing works
GABAergic organization of the cat medial geniculate body
Huang, C. L., Larue, D. T., & Winer, J. A. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991220)415:3 · Cited by 39 · see citing works
Retinal Architecture and Melanopsin-Mediated Pupillary Response Characteristics
Meltzer, E. I., Sguigna, P. V., Subei, A. M., Beh, S. C., Kildebeck, E., Conger, D. L., Conger, A., Lucero, M., Frohman, B. S., Frohman, A. N., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2016.5131 · Cited by 36 · see citing works
Hayter, E. A., & Brown, T. M. (2018) · BMC Biology · doi:10.1186/s12915-018-0552-1 · Cited by 35 · see citing works
Sexton, T. J., Bleckert, A., Turner, M. H., & Gelder, R. N. V. (2015) · Neural Development · doi:10.1186/s13064-015-0042-x · Cited by 34 · see citing works
Melanopsin Cell Dysfunction is Involved in Sleep Disruption in Parkinson’s Disease
Feigl, B., Dumpala, S., Kerr, G., & Zele, A. J. (2020) · Journal of Parkinson s Disease · doi:10.3233/jpd-202178 · Cited by 34 · see citing works
Transcriptomic Signatures of Postnatal and Adult Intrinsically Photosensitive Ganglion Cells
Berg, D. J., Kartheiser, K., Leyrer, M. L., Saali, A., & Berson, D. M. (2019) · eNeuro · doi:10.1523/eneuro.0022-19.2019 · Cited by 30 · see citing works
Influence of Opa1 Mutation on Survival and Function of Retinal Ganglion Cells
González-Menéndez, I., Reinhard, K., Tolivia, J., Wissinger, B., & Münch, T. A. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-16743 · Cited by 24 · see citing works
Early-Stage Alzheimer’s Disease Does Not Alter Pupil Responses to Colored Light Stimuli
Kawasaki, A., Ouanes, S., Crippa, S. V., & Popp, J. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200120 · Cited by 24 · see citing works
Functional organization of midget and parasol ganglion cells in the human retina
Kling, A., Gogliettino, A. R., Shah, N. P., Wu, E. G., Brackbill, N., Sher, A., Litke, A. M., Silva, R. A., & Chichilnisky, E. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.07.240762 · Cited by 24 · see citing works
Extracellular Recordings from Human Retinal Ganglion Cells
Weinstein, G. W., Hobson, R. R., & Baker, F. (1971) · Science · doi:10.1126/science.171.3975.1021 · Cited by 22 · see citing works
Direct visual and circadian pathways target neuroendocrine cells in primates
Abizaid, A., Horvath, B., Keefe, D. L., Leranth, C., & Horvath, T. L. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03737.x · Cited by 22 · see citing works
Intrinsic Photosensitive Retinal Ganglion Cells in the Diurnal Rodent, Arvicanthis ansorgei
Karnas, D., Hicks, D., Mordel, J., Pévet, P., & Meissl, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073343 · Cited by 22 · see citing works
de Lima, R. R. M., Pinato, L., do Nascimento, R. B. S., Engelberth, R. C. G. J., do Nascimento, E. S., Cavalcante, J. C., Britto, L. R. G., Costa, M. S. M. O., & Cavalcante, J. S. (2012) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2012.04.001 · Cited by 18 · see citing works
Rheaume, B. A., Jereen, A., Bolisetty, M. T., Sajid, M. S., Yang, Y. J., Renna, K., Sun, L., Robson, P., & Trakhtenberg, E. F. (2018) · Nature Communications · doi:10.1038/s41467-018-05792-3 · Cited by 13 · see citing works
What is the "spectral diet" of humans?Preprint
Webler, F. S., Spitschan, M., Foster, F., Andersen, M., & Peirson, S. N. (2019) · doi:10.31219/osf.io/dqkv3 · Cited by 6 · see citing works
Melanopsin Effects on Pupil Responses
White, O. B., & Costello, F. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2016.5385 · Cited by 3 · see citing works
Sleep and circadian phenotype in people without cone-mediated visionPreprint
Spitschan, M., Garbazza, C., Kohl, S., & Cajochen, C. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.02.129502 · Cited by 3 · see citing works
Revival of light-evoked neuronal signals in the post-mortem mouse and human retinaPreprint
Abbas, F., Becker, S., Jones, B. W., Mure, L. S., Panda, S., Hanneken, A. M., & Vinberg, F. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.30.180497 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Blue Light Exposure: Ocular Hazards and Prevention—A Narrative Review
Cougnard‐Grégoire, A., Merle, B. M. J., Aslam, T. M., Seddon, J. M., Aknin, I., Klaver, C. C. W., Garhöfer, G., García‐Layana, A., Minnella, A. M., da Silva, R. M., et al. (2023) · Ophthalmology and Therapy · doi:10.1007/s40123-023-00675-3 · Cited by 202 · see citing works
Reducing nighttime light exposure in the urban environment to benefit human health and society
Zielińska-Dąbkowska, K. M., Schernhammer, E. S., Hanifin, J. P., & Brainard, G. C. (2023) · Science · doi:10.1126/science.adg5277 · Cited by 158 · see citing works
Understanding light pollution: Recent advances on its health threats and regulations
Cao, M., Xu, T., & Yin, D. (2022) · Journal of Environmental Sciences · doi:10.1016/j.jes.2022.06.020 · Cited by 122 · see citing works
The cognitive impact of light: illuminating ipRGC circuit mechanisms
Mahoney, H. L., & Schmidt, T. M. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00788-5 · Cited by 81 · see citing works
Spitschan, M., Kervezee, L., Lok, R., McGlashan, E., Najjar, R. P., Allen, A. E., Andersen, M., Bará, S., Blattner, P., Blume, C., et al. (2023) · eBioMedicine · doi:10.1016/j.ebiom.2023.104889 · Cited by 60 · see citing works
Self-citationIt is time for a moonshot to find “Cures” for diabetic retinal disease
Levine, S. R., Sapieha, P. S., Dutta, S., Sun, J. K., & Gardner, T. W. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101051 · Cited by 52 · see citing works
The Blue Light Hazard Versus Blue Light Hype
Mainster, M. A., Findl, O., Dick, H. B., Desmettre, T. J., Ledesma‐Gil, G., Curcio, C. A., & Turner, P. L. (2022) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2022.02.016 · Cited by 54 · see citing works
The Mammalian Circadian Time-Keeping System
Patton, A. P., & Hastings, M. H. (2023) · Journal of Huntington s Disease · doi:10.3233/jhd-230571 · Cited by 50 · see citing works
Gubin, D. G., Danilenko, K. V., Stefani, O., Kolomeichuk, S. N., Markov, A., Petrov, I. M., Voronin, K., Mezhakova, M. S., Borisenkov, M. F., Shigabaeva, A., et al. (2023) · Biology · doi:10.3390/biology13010022 · Cited by 51 · see citing works
Križaj, D., Cordeiro, S., & Strauß, O. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101114 · Cited by 47 · see citing works
Campbell, I., Sharifpour, R., & Vandewalle, G. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5010012 · Cited by 43 · see citing works
Höhn, C., Hahn, M. A., Gruber, G., Pletzer, B. A., Cajochen, C., & Hoedlmoser, K. (2024) · Brain Communications · doi:10.1093/braincomms/fcae173 · Cited by 45 · see citing works
Light Pollution and Oxidative Stress: Effects on Retina and Human Health
Salceda, R. (2024) · Antioxidants · doi:10.3390/antiox13030362 · Cited by 40 · see citing works
PupilEXT: Flexible Open-Source Platform for High-Resolution Pupillometry in Vision Research
Zandi, B., Lode, M., Herzog, A., Sakas, G., & Khanh, T. Q. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.676220 · Cited by 34 · see citing works
Photoreceptor contributions to the human pupil light reflex
Barrionuevo, P. A., Issolio, L., & Tripolone, M. C. (2023) · Journal of Photochemistry and Photobiology · doi:10.1016/j.jpap.2023.100178 · Cited by 33 · see citing works
An Anatomy of Fungal Eye: Fungal Photoreceptors and Signalling Mechanisms
Bayram, Ö., & Bayram, Ö. (2023) · Journal of Fungi · doi:10.3390/jof9050591 · Cited by 30 · see citing works
Menéndez‐Velázquez, A., Morales, D., & García-Delgado, A. B. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031849 · Cited by 31 · see citing works
The impact of lifestyle factors on myopia development: Insights and recommendations
Ba, M., & Li, Z. (2024) · AJO International · doi:10.1016/j.ajoint.2024.100010 · Cited by 29 · see citing works
Chen, H., Shi, X., Liu, N., Jiang, Z., Ma, C., Luo, G., Liu, S., Wei, X., Liu, Y., & Ming, D. (2024) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2024.112998 · Cited by 27 · see citing works
Chaffiol, A., Provansal, M., Joffrois, C., Blaize, K., Labernède, G., Goulet, R., Burban, E., Brazhnikova, E., Duebel, J., Pouget, P., et al. (2021) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2021.11.009 · Cited by 26 · see citing works
Circadian Disruption in Glaucoma: Causes, Consequences, and Countermeasures
Gubin, D. G., Malishevskaya, Т. N., Weinert, D., Zakharova, E., Astakhov, S. Y., & Cornélissen, G. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2912410 · Cited by 25 · see citing works
Perea‐García, J. O., Ramarajan, K., Kret, M. E., Hobaiter, C., & Monteiro, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-20900-6 · Cited by 24 · see citing works
Circadian regulation in aging: Implications for spaceflight and life on earth
Malhan, D., Schoenrock, B., Yalçın, M., Blottner, D., & Relógio, A. (2023) · Aging Cell · doi:10.1111/acel.13935 · Cited by 24 · see citing works
miRNA Studies in Glaucoma: A Comprehensive Review of Current Knowledge and Future Perspectives
Dobrzycka, M., Sulewska, A., Biecek, P., Charkiewicz, R., Karabowicz, P., Charkiewicz, A. E., Gołaszewska, K., Milewska, P., Michalska‐Falkowska, A., Nowak, K., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914699 · Cited by 25 · see citing works
Zang, L., Liu, X., Li, Y., Liu, J., Lu, Q., Zhang, Y., & Meng, Q. (2023) · PLoS ONE · doi:10.1371/journal.pone.0293977 · Cited by 25 · see citing works
Melanopsin-mediated optical entrainment regulates circadian rhythms in vertebrates
Pan, D., Wang, Z., Chen, Y., & Cao, J. (2023) · Communications Biology · doi:10.1038/s42003-023-05432-7 · Cited by 25 · see citing works
Virtual reality-based study assessing the impact of lighting on attention in university classrooms
Cabanes, N. C., Higuera-Trujillo, J. L., & Llinares, C. (2024) · Journal of Building Engineering · doi:10.1016/j.jobe.2024.108902 · Cited by 26 · see citing works
OPA1 Dominant Optic Atrophy: Pathogenesis and Therapeutic Targets
Wong, D., Harvey, J. P., Jurkutė, N., Thomasy, S. M., Moosajee, M., Yu‐Wai‐Man, P., & Gilhooley, M. J. (2023) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0000000000001830 · Cited by 23 · see citing works
Increased ocular dopamine levels in rabbits after blue light stimulation of the optic nerve head
Carpena‐Torres, C., Schilling, T., Huete‐Toral, F., Bahmani, H., & Carracedo, G. (2023) · Experimental Eye Research · doi:10.1016/j.exer.2023.109604 · Cited by 22 · see citing works
Fernandez, F. (2022) · Nature and Science of Sleep · doi:10.2147/nss.s251712 · Cited by 26 · see citing works
The Newborn's Reaction to Light as the Determinant of the Brain's Activation at Human Birth
Polese, D., Riccio, M. L., Fagioli, M., Mazzetta, A., Fagioli, F., Parisi, P., & Fagioli, M. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.933426 · Cited by 22 · see citing works
Depression scores are associated with retinal ganglion cells loss
Gubin, D. G., Neroev, V. V., Malishevskaya, Т. N., Kolomeichuk, S. N., Cornélissen, G., Yuzhakova, N., Власова, А. С., & Weinert, D. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.04.039 · Cited by 20 · see citing works
Understanding the role of chronopharmacology for drug optimization: what do we know?
Fujimura, A., & Ushijima, K. (2023) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2023.2233438 · Cited by 20 · see citing works
Zouache, M. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.778404 · Cited by 19 · see citing works
Kralik, J., & Kleinlogel, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111515 · Cited by 18 · see citing works
Bjerrum, L. B., Nordhus, I. H., Sørensen, L., Wulff, K., Bjorvatn, B., Flo, E., & Visted, E. (2024) · Biological Psychology · doi:10.1016/j.biopsycho.2024.108845 · Cited by 20 · see citing works
Killgore, W. D. S., Alkozei, A., Vanuk, J. R., Reign, D., Grandner, M. A., & Dailey, N. S. (2022) · Neuroreport · doi:10.1097/wnr.0000000000001774 · Cited by 18 · see citing works
Fernandez, F. (2022) · Dove Medical Press (Taylor and Francis Group) · Cited by 18 · see citing works
Zhang, C., Zhu, Z., Zhao, J., Li, Y., Zhang, Z., & Zheng, Y. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.160809 · Cited by 19 · see citing works
Li, H., Gao, M., Song, H., Wu, X. Y., Li, G., Cui, Y., Li, Y., Xie, Z., Ren, Q., & Zhang, H. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1185890 · Cited by 18 · see citing works
Illuminating the way: the role of bright light therapy in the treatment of depression
Rajačić, B. K., Šagud, M., Pivac, N., & Begić, D. (2023) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2023.2273396 · Cited by 19 · see citing works
Impact of light on task‐evoked pupil responses during cognitive tasks
Campbell, I., Beckers, E., Sharifpour, R., Berger, A., Paparella, I., Aizpurua, J. F. B., Koshmanova, E., Mortazavi, N., Sherif, S., & Vandewalle, G. (2023) · Journal of Sleep Research · doi:10.1111/jsr.14101 · Cited by 18 · see citing works
Martínez-Pérez, C., Sánchez‐Tena, M. Á., Sánchez‐González, J., Villa-Collar, C. C., & Alvarez-Peregrina, C. C. (2025) · Acta Ophthalmologica · doi:10.1111/aos.17478 · Cited by 16 · see citing works
Seeing and sensing temporal variations in natural daylight
Pastilha, R., & Hurlbert, A. C. (2022) · Progress in brain research · doi:10.1016/bs.pbr.2022.04.013 · Cited by 17 · see citing works
Joyce, D. S., Houser, K. W., Peirson, S. N., Zeitzer, J. M., & Zele, A. J. (2022) · Cambridge University Press eBooks · doi:10.1017/9781009029865 · Cited by 16 · see citing works
Yoshikawa, T., Obayashi, K., Miyata, K., Saeki, K., & Ogata, N. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.3.24 · Cited by 15 · see citing works
Impact of repeated short light exposures on sustained pupil responses in an fMRI environment
Beckers, E., Campbell, I., Sharifpour, R., Paparella, I., Berger, A., Aizpurua, J. F. B., Koshmanova, E., Mortazavi, N., Talwar, P., Sherif, S., et al. (2023) · Journal of Sleep Research · doi:10.1111/jsr.14085 · Cited by 15 · see citing works
Cabanes, N. C., Higuera-Trujillo, J. L., & Llinares, C. (2023) · Energy and Buildings · doi:10.1016/j.enbuild.2023.113496 · Cited by 13 · see citing works
Is melanopsin activation affecting large field color-matching functions?
Barrionuevo, P. A., Filgueira, C. P., & Cao, D. (2022) · Journal of the Optical Society of America A · doi:10.1364/josaa.457223 · Cited by 13 · see citing works
Li, M., Sun, H., Hou, Z., Hao, S., Jin, L., & Wang, B. (2023) · Small · doi:10.1002/smll.202306451 · Cited by 12 · see citing works
Costello, A., Linning‐Duffy, K., Vandenbrook, C., Donohue, K. D., O’Hara, B. F., Kim, A. B., Lonstein, J. S., & Yan, L. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.04.012 · Cited by 16 · see citing works
Brain stimulation with 40 Hz heterochromatic flicker extended beyond red, green, and blue
Henney, M. A., Carstensen, M. S., Thorning‐Schmidt, M. W., Kubińska, M., Grønberg, M. G., Nguyen, M., Madsen, K. H., Clemmensen, L. K. H., & Petersen, P. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-52679-z · Cited by 12 · see citing works
Correlated color temperature and light intensity: Complementary features in non-visual light field
Argüelles-Prieto, R., Madrid, J. A., Rol, M. A., & Bonmatí‐Carrión, M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0254171 · Cited by 11 · see citing works
Blue-light stimulation of the blind-spot constricts the pupil and enhances contrast sensitivity
Schilling, T., Soltanlou, M., Nuerk, H., & Bahmani, H. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286503 · Cited by 11 · see citing works
Gabinet, N. M. (2024) · Exploration of neuroscience · doi:10.37349/en.2024.00057 · Cited by 10 · see citing works
Kubota, N., Tamori, Y., Baba, K., & Yamanaka, Y. (2022) · Sleep and Biological Rhythms · doi:10.1007/s41105-021-00360-7 · Cited by 10 · see citing works
Chaigne, C., Sapède, D., Cousin, X., Sanchou, L., Blader, P., & Cau, E. (2024) · PLoS Genetics · doi:10.1371/journal.pgen.1011172 · Cited by 9 · see citing works
Screening of genes interacting with high myopia and neuropsychiatric disorders
Liu, Y., Liu, Y., Zhang, W., Xue, Z.-Q., Zhang, F.-X., Xu, W.-G., & Zhuang, W. (2023) · Scientific Reports · doi:10.1038/s41598-023-45463-y · Cited by 9 · see citing works
Sánchez-Cano, A. I., Bartolomé, M. J. L., & Solanas, E. (2025) · Life · doi:10.3390/life15050715 · Cited by 8 · see citing works
Human trichromacy and refractive development
Gawne, T. J., She, Z., & Khanal, S. (2025) · Vision Research · doi:10.1016/j.visres.2025.108632 · Cited by 8 · see citing works
Blue light emitted from digital devices - impact on our sleep
Kurek, J., GADOMSKA, A., GORZYŃSKI, R., MOLCZYK-SIEŃCZAK, J., Garstka, M., DOMINIK, H., Czudy, Z., PAWĘSKA, W., RADWAŃSKI, J., & POLATOWSKA, M. (2023) · Journal of Education Health and Sport · doi:10.12775/jehs.2023.40.01.007 · Cited by 7 · see citing works
Wong, N., Yip, S. P., & Huang, C.-L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713652 · Cited by 8 · see citing works
Yuan, M., Liu, H., Zhu, R., Li, Y., Song, S., & Yang, A. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13726 · Cited by 12 · see citing works
Effects of blue light during and after exposure on auditory working memory
Kim, K., Yokosawa, K., Okada, K., Onishi, H., Tan, Y., & Lee, S. (2025) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-025-00395-6 · Cited by 6 · see citing works
ipRGC properties prevent light from shifting the SCN clock during daytime
Komal, R., Beier, C., Nath, A., Grimes, W. N., Wang, H. M., Berry, M. H., Gao, C., Yang, S. Y., Thurman, M., Ostermeyer, G. P., et al. (2026) · Nature · doi:10.1038/s41586-025-09894-z · Cited by 6 · see citing works
Effect of Light on Dairy Cattle in Farm Conditions – A Review
Adamczyk, K., Herbut, P., Godyń, D., Angrecka, S., Kupczyński, R., & Vieira, F. M. C. (2024) · Annals of Animal Science · doi:10.2478/aoas-2024-0052 · Cited by 6 · see citing works
Nagata, E., Takao, M., Toriumi, H., Suzuki, M., Fujii, N., Kohara, S., Tsuda, A., Nakayama, T., Kadokura, A., & Hadano, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147980 · Cited by 6 · see citing works
The importance of ligand gated ion channels in sleep and sleep disorders
Arnold, E. C., Soler-Llavina, G. J., Kambara, K., & Bertrand, D. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115532 · Cited by 7 · see citing works
Basics, benefits, and pitfalls of pupillometers assessing visual function
Philibert, M., & Miléa, D. (2024) · Eye · doi:10.1038/s41433-024-03151-9 · Cited by 6 · see citing works
Murukesu, R. R., Alkaff, Z. A., Bridges, C., & Spitschan, M. (2025) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd016157 · Cited by 5 · see citing works
Matynia, A., Recio, B. S., Myers, Z., Parikh, S., Goit, R. K., Brecha, N. C., & Müller, L. P. D. S. (2024) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.65.1.28 · Cited by 6 · see citing works
Sleep Patterns in Children With Blindness: A Comparison With Normally Sighted Peers
Adhikari, S., van Nispen, R. M. A., Poudel, M. P., van Rens, F. E. C. A., Elsman, E. B. M., van der Werf, Y. D., & van Rens, G. H. M. B. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.14.46 · Cited by 5 · see citing works
Georgieva, I., Tchekalarova, J. D., Nenchovska, Z., Kortenska, L., & Tzoneva, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910294 · Cited by 5 · see citing works
Seeing the Light: Perception and Discrimination of Illumination Color
Hurlbert, A. C., & Yu, C. (2025) · Annual Review of Vision Science · doi:10.1146/annurev-vision-121423-013755 · Cited by 5 · see citing works
Wong, Q. Y. A., Lim, J. J., Ng, J. Y., Lim, Y. Y. E., Sio, Y. Y., & Chew, F. T. (2024) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-024-00356-5 · Cited by 5 · see citing works
Light pollution: time to consider testicular effects
Liu, P. Y. (2024) · Frontiers in Toxicology · doi:10.3389/ftox.2024.1481385 · Cited by 5 · see citing works
A study on the effect of blue light on kidney stone formation in rats via the brain-kidney axis
Fang, D., Hu, Y., Wang, C., Fan, J., & Wen, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-85586-y · Cited by 4 · see citing works
Sánchez-Cano, A. I., Blasco-Yachemet, L., & Aporta, J. (2025) · Buildings · doi:10.3390/buildings15111779 · Cited by 4 · see citing works
A new method to quantify the human visual threshold from melanopsin sensitive ganglion cells
Rabin, J. C., Poole, E., Price, W., Kaur, G., Hall, K., Sailors, V., Andrews, B., & Somphruek, R. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1132230 · Cited by 4 · see citing works
Guia, I. D., Eslick, S., Naismith, S. L., Kanduri, S., Shah, T. M., & Martins, R. N. (2024) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-230150 · Cited by 4 · see citing works
Ritter, P. S., Glenn, T., Achtyes, E. D., Alda, M., Ağaoğlu, E., Altınbaş, K., Andreassen, O. A., Angelopoulos, E. K., Ardau, R., Aydın, M., et al. (2024) · International Journal of Bipolar Disorders · doi:10.1186/s40345-024-00364-5 · Cited by 3 · see citing works
Hua, Z., Shen, Y., & Zhou, X. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18030282 · Cited by 4 · see citing works
Inner-retinal changes in AMD: Evidence, mechanisms, and future perspectives
Trinh, M., Kalloniatis, M., Jones, B. W., Yiu, G. C., Borrelli, E., & Nivison‐Smith, L. (2026) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2026.101463 · Cited by 3 · see citing works
Royer, M., Abboushi, B., & Bermudez, E. R.-F. (2025) · LEUKOS The Journal of the Illuminating Engineering Society of North America · doi:10.1080/15502724.2024.2434977 · Cited by 4 · see citing works
Integrating monitors into circadian lighting strategies for offices
Dianagri, A. T., Göçer, Ö., & Hu, W. (2025) · Journal of Building Engineering · doi:10.1016/j.jobe.2025.113051 · Cited by 3 · see citing works
Das, G., & Milner, T. E. (2024) · Frontiers in Photonics · doi:10.3389/fphot.2024.1389683 · Cited by 2 · see citing works
Derengowski, N., Knoop, M., & Völker, S. (2025) · Lighting Research & Technology · doi:10.1177/14771535251339672 · Cited by 2 · see citing works
Volf, C., Aggestrup, A. S., Petersen, P. M., Dam-Hansen, C., Knorr, U., Petersen, E. E., Engstrøm, J., Hansen, T. S., Madsen, H. Ø., Hageman, I., et al. (2025) · Chronobiology International · doi:10.1080/07420528.2025.2530129 · Cited by 3 · see citing works
Photoreceptor-specific scene statistics reveal melanopic structure in natural environments
Tabandeh, N., & Spitschan, M. (2026) · iScience · doi:10.1016/j.isci.2026.116661 · Cited by 2 · see citing works
Chronobiologic treatments for mood disorders
Dallaspezia, S., & Benedetti, F. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-323-90918-1.00011-3 · Cited by 3 · see citing works
The impact of circadian rhythms on retinal immunity
Ren, H., Yuan, Y., Zhang, D., Xing, Y., & Chen, Z. (2025) · Chronobiology International · doi:10.1080/07420528.2025.2460675 · Cited by 2 · see citing works
Srikanta, S. B., Brown, T. W., Malescot, A., Cloutier, M., Zhu, L., Coutanson, C., Malki, M., Storch, K.-F., Rungta, R. L., Cayouette, M., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70018 · Cited by 2 · see citing works
Sleep links hippocampal propensity for epileptiform activity to its viscerosensory inputs
Levichkina, E. V., Pigarev, I. N., Grayden, D. B., Petrou, S., & Vidyasagar, T. R. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1559529 · Cited by 1 · see citing works
Multimodality in the Collicular Pathway: Towards Compensatory Visual Processes
Rusciano, D., & Bagnoli, P. (2025) · Cells · doi:10.3390/cells14090635 · Cited by 2 · see citing works
Gan, J., Wang, M., Li, C.-Y., Huang, Y., Liu, Z., Bai, W., Xu, W., Sun, M.-H., Kang, M., Morgan, I. G., et al. (2025) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-025-06950-2 · Cited by 2 · see citing works
Regional activity within the human amygdala varies with season, mood and illuminance
Campbell, I., Balda, J., Sharifpour, R., Paparella, I., Beckers, E., Mortazavi, N., Read, J., Phillips, C. L. M., Collette, F., Talwar, P., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67715-3 · Cited by 2 · see citing works
Open-source Python module for the analysis of personalized light exposure dataPreprint
Hammad, G. H., Wulff, K., Skene, D. J., Münch, M. Y., & Spitschan, M. (2023) · doi:10.31219/osf.io/msk9n · Cited by 2 · see citing works
Exploring the relationship between melanopsin gene variants, sleep, and markers of brain health
Armstrong, A. M., O’Brien, E. K., Porter, T., Doré, V., Bourgeat, P., Maruff, P. T., Rowe, C. C., Villemagne, V. L., Rainey‐Smith, S. R., & Laws, S. M. (2025) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.70056 · Cited by 1 · see citing works
Effects of binocularity and eye dominance on visually-driven ocular tracking
Seyedmadani, K., Tucker, K. A., Anderson, M. R., Akay, M., Akay, M., & Stone, L. S. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1504628 · Cited by 1 · see citing works
In Vitro retinal ganglion cell differentiation and enrichment under the scope: do subtypes matter?
Baakdhah, T. W., & Sivak, J. M. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1750142 · Cited by 1 · see citing works
- Authors
- Mure, L. S.
- Affiliations
- University of Bern (CH)
- Corresponding author
- Mure, Ludovic S.
- ORCID
- Mure, Ludovic S.
- Venue
- Frontiers in Neurology
- Publisher
- Frontiers Media SA
- Published
- 2021-03-25
- Volume
- 12
- Pages
- 636330-636330
- ISSN
- 1664-2295 (ISSN-L)
- PMC
- PMC8027232
- OpenAlex
- W3151649762
- Cited by
- 151
- References
- 116
- Citations by year
- 2026: 32 · 2025: 31 · 2024: 27 · 2023: 37 · 2022: 19 · 2021: 5
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Neurology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- BORIS (University Library Bern) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Open Access CRIS of the University of Bern
- Funders
- University of Bern
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- intrinsically photosensitive retinal ganglion cells, melanopsin, human retina, non-image-forming vision, circadian entrainment, pupillary light reflex, melatonin suppression, light perception, phototherapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
