Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 267

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Ascorbate oxidation by iron, copper and reactive oxygen species: review, model development, and derivation of key rate constants

Open access
Shen, Jiaqi, Griffiths, Paul T., Campbell, Steven J., Utinger, Battist, Kalberer, Markus, Paulson, Suzanne E.·2021·Scientific Reports
DOI 10.1038/s41598-021-86477-8
Open this paper in CoChat — free account

Abstract

Ascorbic acid is among the most abundant antioxidants in the lung, where it likely plays a key role in the mechanism by which particulate air pollution initiates a biological response. Because ascorbic acid is a highly redox active species, it engages in a far more complex web of reactions than a typical organic molecule, reacting with oxidants such as the hydroxyl radical as well as redox-active transition metals such as iron and copper. The literature provides a solid outline for this chemistry, but there are large disagreements about mechanisms, stoichiometries and reaction rates, particularly for the transition metal reactions. Here we synthesize the literature, develop a chemical kinetics model, and use seven sets of laboratory measurements to constrain mechanisms for the iron and copper reactions and derive key rate constants. We find that micromolar concentrations of iron(III) and copper(II) are more important sinks for ascorbic acid (both AH 2 and AH−) than reactive oxygen species. The iron and copper reactions are catalytic rather than redox reactions, and have unit stoichiometries: Fe(III)/Cu(II) + AH 2/AH− + O 2→ Fe(III)/Cu(II) + H 2 O 2 + products. Rate constants are 5.7 × 10 4 and 4.7 × 10 4 M−2 s−1 for Fe(III) + AH 2/AH−and 7.7 × 10 4 and 2.8 × 10 6 M−2 s−1 for Cu(II) + AH 2/AH−, respectively.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s41598-021-86477-8

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 58 references

Cited by

See all 267

Metadata

Authors
Shen, J., Griffiths, P. T., Campbell, S. J., Utinger, B., Kalberer, M., & Paulson, S. E.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2021-04-01
Volume
11
Issue
1
Pages
7417-7417
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-021-86477-8
OpenAlex
W3151631725
Cited by
267
References
58
FWCI
16.37
Type
journal article
Language
en
Open access
gold

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Ascorbate oxidation by iron, copper and reactive oxygen species: review, model development, and derivation of key rate constants. https://app.cochat.ai/papers/10.1038/s41598-021-86477-8
The paper
Shen, J., Griffiths, P. T., Campbell, S. J., Utinger, B., Kalberer, M., & Paulson, S. E. (2021). Ascorbate oxidation by iron, copper and reactive oxygen species: review, model development, and derivation of key rate constants. Scientific Reports. https://doi.org/10.1038/s41598-021-86477-8

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.