CoChat
Sign Up
Cited by 15Infectious Encephalopathies and EncephalitisViral Infections and Immunology ResearchVirology and Viral Diseases

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Multicenter prospective surveillance study of viral agents causing meningoencephalitis

Open access
Törün, Selda Hançerli, Kaba, Özge, Yakut, Nurhayat, Kadayıfçı, Eda Kepenekli, Kara, Manolya, Yanartaş, Mehpare Sarı, Somer, Ayper, Duramaz, Burcu Bursal, Türel, Özden, Dalgıç, Nazan, Alp, Emel Ekşi, Salı, Enes, Çakır, Deniz, Önal, Pınar, Çokuğraş, Haluk, Aygün, Fatma Deniz, Karbuz, Adem, Önel, Mustafa, Meşe, Sevim, Ağaçfidan, Ali·2021·Scientific Reports
DOI 10.1038/s41598-021-86687-0PMC PMC8010096
Open this paper in CoChat — free accountOpen PDF

Abstract

The frequency of bacterial factors causing central nervous system infections has decreased as a result of the development of our national immunization program. In this study, it is aimed to obtain the data of our local surveillance by defining the viral etiology in cases diagnosed with meningoencephalitis for 1 year. Previously healhty 186 children, who applied with findings suggesting viral meningoencephalitis to 8 different tertiary health centers between August 2018 and August 2019, in Istanbul, were included. The cerebrospinal fluid (CSF) sample was evaluated by polymerase chain reaction. The M:F ratio was 1.24 in the patient group, whose age ranged from 1 to 216 months (mean 40.2 ± 48.7). Viral factor was detected in 26.8%. Enterovirus was the most common agent (24%) and followed by Adenovirus (22%) and HHV type 6 (22%). In the rest of the samples revealed HHV type 7 (10%), EBV (6%), CMV (6%), HSV type 1 (6%), Parvovirus (4%) and VZV (2%). The most common symptoms were fever (79%) and convulsions (45.7%). Antibiotherapy and antiviral therapy was started 48.6% and 4% respectively. Mortality and sequela rate resulted 0.53% and 3.7%, respectively. This highlights the importance of monitoring trends in encephalitis in Turkey with aview to improving pathogen diagnosis for encephalitis and rapidly identifying novel emerging encephalitis-causing pathogens that demand public health action especially in national immunisation programme.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s41598-021-86687-0

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 Distribution of participants by age group and gender.
Figure 1 Distribution of participants by age group and gender.CC BY · PubMed Central
Figure 2 Application seasons of patients who are positive as a result of viral panel. HHV Human Herpes Virus, CMV Cytomegalovirus, HSV Herpes Simplex Virus, EBV Ebstein Barr Virus, VZV Varicella Zoster Virus.
Figure 2 Application seasons of patients who are positive as a result of viral panel. HHV Human Herpes Virus, CMV Cytomegalovirus, HSV Herpes Simplex Virus, EBV Ebstein Barr Virus, VZV Varicella Zoster Virus.CC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 17 references

Research works printed but not linked: 1

  1. Khetsuriani, N. et al. Enterovirus surveillance–United States, 1970–2005. MMWR Surveill. Summ. 55, 1 (2006).

Cited by

Sorted by citations

See all 15

Related

See all

Metadata

Authors
Törün, S. H., Kaba, Ö., Yakut, N., Kadayıfçı, E. K., Kara, M., Yanartaş, M. S., Somer, A., Duramaz, B. B., Türel, Ö., Dalgıç, N., Alp, E. E., Salı, E., Çakır, D., Önal, P., Çokuğraş, H., Aygün, F. D., Karbuz, A., Önel, M., Meşe, S., & Ağaçfidan, A.
Affiliations
  • Istanbul University (TR)
  • Marmara University (TR)
  • Bezmiâlem Vakıf Üniversitesi (TR)
  • Sağlık Bilimleri Üniversitesi (TR)
  • Ümraniye Eğitim ve Araştırma Hastanesi (TR)
  • Istanbul University-Cerrahpaşa (TR)
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2021-03-30
Volume
11
Issue
1
Pages
7216-7216
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-021-86687-0
PMC
PMC8010096
OpenAlex
W3145486091
Cited by
15
References
17
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 2
FWCI
0.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Dspace Repository (Marmara Üniversitesi) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
This study was supported by the Turkish Pediatric Institution within the framework of the "Initial R
Topics
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
viral meningoencephalitis, viral etiology, enterovirus, adenovirus, human herpesvirus 6, human herpesvirus 7, herpes simplex virus type 1, cytomegalovirus, varicella-zoster virus, parvovirus, cerebrospinal fluid PCR, pediatric encephalitis, immunization programs, Istanbul
MeSH terms
Adolescent, Antiviral Agents, Child, Child, Preschool, Enterovirus Infections, Enterovirus, Female, Humans, Infant, Infant, Newborn, Male, Meningoencephalitis, Prospective Studies, Virus Diseases, Viruses

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Multicenter prospective surveillance study of viral agents causing meningoencephalitis. https://app.cochat.ai/papers/10.1038/s41598-021-86687-0
The paper
Törün, S. H., Kaba, Ö., Yakut, N., Kadayıfçı, E. K., Kara, M., Yanartaş, M. S., Somer, A., Duramaz, B. B., Türel, Ö., Dalgıç, N., Alp, E. E., Salı, E., Çakır, D., Önal, P., Çokuğraş, H., Aygün, F. D., Karbuz, A., Önel, M., Meşe, S., & Ağaçfidan, A. (2021). Multicenter prospective surveillance study of viral agents causing meningoencephalitis. Scientific Reports. https://doi.org/10.1038/s41598-021-86687-0