Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 57

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Persistent post-concussive syndrome in children after mild traumatic brain injury is prevalent and vastly underdiagnosed

Fried, Eli, Balla, Uri, Catalogna, Merav, Kozer, Eran, Oren-Amit, Adi, Hadanny, Amir, Efrati, Shai·2022·Scientific Reports
DOI 10.1038/s41598-022-08302-0
Open this paper in CoChat — free account

Abstract

Data on epidemiology and prognosticators of persistent post-concussion syndrome (PPCS) after mild traumatic brain injury (mTBI) in the pediatric population is scarce. The aim of this study was to evaluate the prevalence of PPCS in children after mTBI and to identify clinical variables in children who are at high risk for developing PPCS. A multicenter, retrospective matched cohort in which PPCS symptoms were evaluated in children 8–15-year-old, 6–60 months after being admitted to the emergency department because of mTBI. The control group included children admitted to the emergency department because of uncomplicated distal radius fractures. The children's guardians were interviewed for the presence of PPCS symptoms using the "Rivermead Post-Concussion Questionnaire". A multivariable logistic regression model was used to identify predictors of PPCS. Two-hundred and five children were included in the mTBI group and 205 in the control. The median time from the injury was 33.5 months in the mTBI group and 33.8 in the control. The prevalence of PPCS in the mTBI group was 25.3% and PPCS like symptoms in the control was 2.4%, p < 0.001. Within the 6–60 months period, the PPCS prevalence was not influenced by the time that elapsed from the injury. In the mTBI group, motor vehicle accidents and adolescence were found to be risk factors for PPCS. PPCS is underdiagnosed in the pediatric population and 25% of children admitted to the ED due to mTBI may suffer from PPCS. Screening guidelines should be implemented to identify and properly treat these children.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s41598-022-08302-0

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 41

  1. Guerrero, J. L., Thurman, D. J. & Sniezek, J. E. Emergency department visits associated with traumatic brain injury: United States, 1995–1996. Brain Inj. 14(2), 181–186 (2000). · DOI
  2. Kirkwood, M. W. et al. Management of pediatric mild traumatic brain injury: A neuropsychological review from injury through recovery. Clin. Neuropsychol. 22(5), 769–800 (2008). · DOI · Paper page
  3. Taylor, C. A. et al. Traumatic brain injury-related emergency department visits, hospitalizations, and deaths: United States, 2007 and 2013. MMWR Surveill. Summ. 66(9), 1–16 (2017). · DOI · Paper page
  4. Cassidy, J. D. et al. Incidence, risk factors and prevention of mild traumatic brain injury: Results of the WHO collaborating centre task force on mild traumatic brain injury. J. Rehabil. Med. 43 Suppl, 28–60 (2004). · DOI · Paper page
  5. Boussi-Gross, R. et al. Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury: Randomized prospective trial. PLoS One 8(11), e79995 (2013). · DOI · Paper page
  6. Yeates, K. O. et al. Postconcussive symptoms in children with mild closed head injuries. J. Head Trauma Rehabil. 14(4), 337–350 (1999). · DOI · Paper page
  7. Steindel, S. J. International classification of diseases, 10th edition, clinical modification and procedure coding system: Descriptive overview of the next generation HIPAA code sets. J. Am. Med. Inform. Assoc. 17(3), 274–82 (2010). · DOI · Paper page
  8. Hadanny, A. & Efrati, S. Treatment of persistent post-concussion syndrome due to mild traumatic brain injury: Current status and future directions. Expert Rev. Neurother. 16(8), 875–887 (2016). · DOI · Paper page
  9. Ayr, L. K. et al. Dimensions of postconcussive symptoms in children with mild traumatic brain injuries. J. Int. Neuropsychol. Soc. 15(1), 19–30 (2009). · DOI
  10. Kant, R. et al. Tc-HMPAO SPECT in persistent post-concussion syndrome after mild head injury: Comparison with MRI/CT. Brain Inj. 11(2), 115–124 (1997). · DOI
  11. Barlow, K. M. et al. Epidemiology of postconcussion syndrome in pediatric mild traumatic brain injury. Pediatrics 126(2), e374–e381 (2010). · DOI · Paper page
  12. Ewing-Cobbs, L., et al., Persistent postconcussion symptoms after injury. Pediatrics. 142(5), (2018) · DOI
  13. Yeates, K. O. et al. Longitudinal trajectories of postconcussive symptoms in children with mild traumatic brain injuries and their relationship to acute clinical status. Pediatrics 123(3), 735–743 (2009). · DOI · Paper page
  14. Malec, J. F. et al. The mayo classification system for traumatic brain injury severity. J. Neurotrauma 24(9), 1417–1424 (2007). · DOI · Paper page
  15. Lefevre-Dognin, C. et al. Definition and epidemiology of mild traumatic brain injury. Neurochirurgie 67(3), 218–221 (2020). · DOI
  16. Riemann, L. et al. Persistent postconcussive symptoms in children and adolescents with mild traumatic brain injury receiving initial head computed tomography. J. Neurosurg. Pediatr. 27(5), 538–547 (2021). · DOI
  17. Babcock, L. et al. Predicting postconcussion syndrome after mild traumatic brain injury in children and adolescents who present to the emergency department. JAMA Pediatr. 167(2), 156–161 (2013). · DOI · Paper page
  18. Potter, S. et al. The rivermead post concussion symptoms questionnaire: A confirmatory factor analysis. J. Neurol. 253(12), 1603–1614 (2006). · DOI · Paper page
  19. Smith-Seemiller, L. et al. Presence of post-concussion syndrome symptoms in patients with chronic pain vs mild traumatic brain injury. Brain Inj. 17(3), 199–206 (2003). · DOI · Paper page
  20. Mittenberg, W. & Strauman, S. Diagnosis of mild head injury and the postconcussion syndrome. J. Head Trauma Rehabil. 15(2), 783–791 (2000). · DOI
  21. Thornhill, S. et al. Disability in young people and adults one year after head injury: Prospective cohort study. BMJ 320(7250), 1631–1635 (2000). · DOI · Paper page
  22. Silver, J. M., McAllister, T. W. & Yudofsky, S. C. Textbook of Traumatic Brain Injury 2nd edn, 664 (American Psychiatric Pub. xxii, 2011). · DOI · Paper page
  23. Sterr, A. et al. Are mild head injuries as mild as we think? Neurobehavioral concomitants of chronic post-concussion syndrome. BMC Neurol. 6, 7 (2006). · DOI
  24. Iverson, G. L. Outcome from mild traumatic brain injury. Curr. Opin. Psychiatr. 18(3), 301–317 (2005). · DOI · Paper page
  25. King, N. S. & Kirwilliam, S. Permanent post-concussion symptoms after mild head injury. Brain Inj. 25(5), 462–470 (2011). · DOI
  26. Hiploylee, C. et al. Longitudinal study of postconcussion syndrome: Not everyone recovers. J. Neurotrauma 34(8), 1511–1523 (2017). · DOI · Paper page
  27. King, N. Permanent post concussion symptoms after mild head injury: A systematic review of age and gender factors. NeuroRehabilitation 34(4), 741–748 (2014). · DOI
  28. Albanese, B. J. et al. Anxiety sensitivity mediates gender differences in post-concussive symptoms in a clinical sample. Psychiatr. Res. 252, 242–246 (2017). · DOI
  29. Truss, K. et al. Trajectories and risk factors for post-traumatic stress symptoms following pediatric concussion. J. Neurotrauma 34(14), 2272–2279 (2017). · DOI
  30. Caze, T. et al. A prospective pilot study of anxiety sensitivity and adolescent sports-related concussion. Arch. Clin. Neuropsychol. 36(6), 930–939 (2020).
  31. Sigalas, P. D., Barkla, X. & McArdle, P. Underdiagnosis of depression in young people. BMJ 348, 170 (2014). · DOI
  32. Wright, K. D. & Asmundson, G. J. Health anxiety in children: Development and psychometric properties of the childhood illness attitude scales. Cogn. Behav. Ther. 32(4), 194–202 (2003). · DOI
  33. Lumba-Brown, A. et al. Centers for disease control and prevention guideline on the diagnosis and management of mild traumatic brain injury among children. JAMA Pediatr. 172(11), e182853 (2018). · DOI · Paper page
  34. Barlow, K. M. et al. The incidence of postconcussion syndrome remains stable following mild traumatic brain injury in children. Pediatr. Neurol. 53(6), 491–497 (2015). · DOI
  35. McMahon, P. et al. Symptomatology and functional outcome in mild traumatic brain injury: Results from the prospective TRACK-TBI study. J. Neurotrauma 31(1), 26–33 (2014). · DOI · Paper page
  36. Moore, R. D. et al. The persistent influence of pediatric concussion on attention and cognitive control during flanker performance. Biol. Psychol. 109, 93–102 (2015). · DOI
  37. Ransom, D. M. et al. Academic effects of concussion in children and adolescents. Pediatrics 135(6), 1043–1050 (2015). · doi:10.1542/peds.2014-3434
  38. Corwin, D. J. et al. Characteristics and outcomes for delayed diagnosis of concussion in pediatric patients presenting to the emergency department. J. Emerg. Med. 59(6), 795–804 (2020). · DOI
  39. Zogg, C. K. et al. The epidemiology of pediatric head injury treated outside of hospital emergency departments. Epidemiology 29(2), 269–279 (2018). · DOI
  40. Thomas, M. et al. The structure of the rivermead post-concussion symptoms questionnaire in Australian adults with traumatic brain injury. Brain Impair. 19(2), 166–182 (2018). · DOI
  41. Lannsjo, M. et al. Internal construct validity of the rivermead post-concussion symptoms questionnaire. J. Rehabil. Med. 43(11), 997–1002 (2011). · DOI

Cited by

See all 57

Metadata

Authors
Fried, E., Balla, U., Catalogna, M., Kozer, E., Oren-Amit, A., Hadanny, A., & Efrati, S.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2022-03-14
Volume
12
Issue
1
ISSN
2045-2322
DOI
10.1038/s41598-022-08302-0
Cited by
57
References
4
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.