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Cited by 17Elasticity and Material ModelingBurn Injury Management and OutcomesWound Healing and Treatments

Thermally damaged porcine skin is not a surrogate mechanical model of human skin

Open access
Gallagher, Samara, Kruger, Uwe, Josyula, Kartik, Rahul, Gong, Alex, Song, Agnes, Sweet, Robert, Makled, Basiel +3 more·2022·Scientific Reports
DOI 10.1038/s41598-022-08551-zPMC PMC8927453
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Abstract

Porcine skin is considered a de facto surrogate for human skin. However, this study shows that the mechanical characteristics of full thickness burned human skin are different from those of porcine skin. The study relies on five mechanical properties obtained from uniaxial tensile tests at loading rates relevant to surgery: two parameters of the Veronda-Westmann hyperelastic material model, ultimate tensile stress, ultimate tensile strain, and toughness of the skin samples. Univariate statistical analyses show that human and porcine skin properties are dissimilar (p < 0.01) for each loading rate. Multivariate classification involving the five mechanical properties using logistic regression can successfully separate the two skin types with a classification accuracy exceeding 95% for each loading rate individually as well as combined. The findings of this study are expected to guide the development of effective training protocols and high-fidelity simulators to train burn care providers.

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Research works printed but not linked: 25

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Cited by

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Authors
Gallagher, S., Kruger, U., Josyula, K., Rahul, Gong, A., Song, A., Sweet, R., Makled, B., Parsey, C., Norfleet, J., & De, S.
Affiliations
  • Rensselaer Polytechnic Institute (US)
  • University of Washington (US)
  • Combat Capabilities Development Command Soldier Center (US)
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2022-03-16
Volume
12
Issue
1
Pages
4565-4565
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-022-08551-z
PMC
PMC8927453
OpenAlex
W4220684146
Cited by
17
References
1
Citations by year
2026: 5 · 2025: 5 · 2024: 4 · 2023: 3
FWCI
0.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
U.S. Army Futures Command, Combat Capabilities Development Command Soldier Center STTC (W911NF-17-2-0022, W912CG-20-2-0004)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
  • Health Sciences › Medicine › Epidemiology › Burn Injury Management and Outcomes
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Keywords
porcine skin, human skin, burned skin, skin biomechanics, uniaxial tensile testing, ultimate tensile strength, ultimate tensile strain, toughness, skin tissue engineering, high-fidelity simulators
MeSH terms
Animals, Biomechanical Phenomena, Humans, Skin, Stress, Mechanical, Swine, Tensile Strength

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