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Cited by 143Gut microbiota and healthInfant Nutrition and HealthOral microbiology and periodontitis research

Development of gut microbiota during the first 2 years of life

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Wernroth, Mona-Lisa, Peura, Sari, Hedman, Anna M., Hetty, Susanne, Vicenzi, Silvia, Kennedy, Beatrice, Fall, Katja, Svennblad, Bodil +10 more·2022·Scientific Reports
DOI 10.1038/s41598-022-13009-3PMC PMC9156670
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Abstract

Although development of microbiota in childhood has been linked to chronic immune-related conditions, early childhood determinants of microbiota development have not been fully elucidated. We used 16S rRNA sequencing to analyse faecal and saliva samples from 83 children at four time-points during their first 2 years of life and from their mothers. Our findings confirm that gut microbiota in infants have low diversity and highlight that some properties are shared with the oral microbiota, although inter-individual differences are present. A considerable convergence in gut microbiota composition was noted across the first 2 years of life, towards a more diverse adult-like microbiota. Mode of delivery accounted for some of the inter-individual variation in early childhood, but with a pronounced attenuation over time. Our study extends previous research with further characterization of the major shift in gut microbiota composition during the first 2 years of life.

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  • The interaction between the gut microbiota and the immune system plays a crucial role in maintaining overall health.

    “The symbiotic relationship between the gut microbiome and the immune system is crucial (2).”

    From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [2]

  • The gut-brain axis relies on intricate signaling pathways, including neurological, immunological, and endocrine mechanisms, with the vagus nerve serving as a crucial conduit for bidirectional communication between the digestive tract and the central nervous system.

    “The gut-brain axis relies on intricate signaling pathways, including neurological, immunological, and endocrine mechanisms, with the vagus nerve serving as a crucial conduit for bidirectional communication between the digestive tract and the central nervous system (2).”

    From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [2]

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Authors
Wernroth, M.-L., Peura, S., Hedman, A. M., Hetty, S., Vicenzi, S., Kennedy, B., Fall, K., Svennblad, B., Andolf, E., Pershagen, G., Theorell-Haglöw, J., Nguyen, D., Sayols-Baixeras, S., Dekkers, K. F., Bertilsson, S., Almqvist, C., Dicksved, J., & Fall, T.
Affiliations
  • Uppsala University (SE)
  • Karolinska Institutet (SE)
  • Örebro University (SE)
  • Danderyds sjukhus (SE)
  • Swedish University of Agricultural Sciences (SE)
  • Karolinska University Hospital (SE)
Corresponding author
Fall, Tove
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2022-05-31
Volume
12
Issue
1
Pages
9080-9080
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-022-13009-3
PMC
PMC9156670
OpenAlex
W4281918806
Cited by
143
References
50
Citations by year
2026: 30 · 2025: 41 · 2024: 45 · 2023: 26 · 2017: 1
FWCI
9.14
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Vetenskapsrådet (2018-02640, 2015-03477)
  • Swedish Initiative for Research on Microdata in the Social And Medical Sciences (340-2013-5867)
  • the Strategic Research Program in Epidemiology at Karolinska Institutet
  • Forskningsrådet om Hälsa, Arbetsliv och Välfärd (2015-00289)
  • Hjärt-Lungfonden (20180512)
  • Uppsala Antibiotic Center
  • EXODIAB
  • Diabetesfonden
  • European Research Council Starting Grant (801965)
  • Uppsala University
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords
gut microbiota development, infancy, early childhood, microbial diversity, oral microbiota, fecal microbiota, saliva microbiota, mode of delivery, interindividual variability, maternal microbiota
MeSH terms
Gastrointestinal Microbiome, Adult, Child, Child, Preschool, Feces, Female, Humans, Infant, Mothers, RNA, Ribosomal, 16S, Microbiota

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