Oral Microbiome Alterations Associated with Early Childhood Caries Highlight the Importance of Carbohydrate Metabolic Activities
Open accessAbstract
Dental caries is a highly prevalent oral disease that can lead to severe dental damage and may greatly compromise the quality of life of the affected individuals. Previous studies, including those based on 16S rRNA gene, have revealed that the oral microbiota plays a prominent role in development of the disease. But the approach of those studies was limited in analyzing several key microbiome traits, including species- or strain-level composition and functional profile. Here, we performed metagenomic analyses for a cohort of preschool children with or without caries. Our results showed that caries was associated with extensive microbiota differences at various taxonomic and functional levels. Some caries-associated species had not been previously reported, some of which may have significant clinical implications. A microbiome gene catalogue from children with caries was constructed for the first time. The results demonstrated that caries is associated with alterations of the oral microbiome, including changes in microbial composition and metabolic functional profile.
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Dysbiosis is prompted by various factors, including host diet, inflammatory responses, systemic disruptions, and habits such as alcohol intake, smoking tobacco and consuming alcohol.
“Such dysbiosis is prompted by various factors, including host diet, inflammatory responses, systemic disruptions, and habits such as alcohol intake, smoking tobacco and consuming alcohol.50, 180, 181, 182, 183, 184, 185, 186”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [180]
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The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755 · see citing works
- Authors
- Wang, Y., Wang, S., Wu, C., Chen, X., Duan, Z., Xu, Q., Jiang, W., Xu, L., Wang, T., Su, L., Wang, Y., Chen, Y., Zhang, J., Huang, Y., Tong, S., Zhou, C., Deng, S., & Qin, N.
- Affiliations
- Zhejiang University (CN)
- Tongji University (CN)
- Realbio Genomics Institute, Shanghai, China
- First Affiliated Hospital Zhejiang University (CN)
- Corresponding author
- Deng, Shuli
- Qin, Nan
- ORCID
- Venue
- mSystems
- Publisher
- American Society for Microbiology
- Published
- 2019-12-17
- Volume
- 4
- Issue
- 6
- ISSN
- 2379-5077 (ISSN-L)
- PMC
- PMC6832018
- OpenAlex
- W2984207160
- Cited by
- 105
- References
- 67
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 12 · 2023: 20 · 2022: 23 · 2021: 21 · 2020: 5 · 2019: 1
- FWCI
- 14.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mSystems (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- China State Key Clinical Department of China (2011)
- General project of health and family planning commission of zhejiang province (2016KYA118)
- Natural Science Foundation of Zhejiang Province (LR15H030002, LY17H140004, LGF18H140004, LQ19H140002)
- National Natural Science Foundation of China (81371142, 31670118)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Keywords
- early childhood caries, oral microbiota, carbohydrate metabolism, preschool children, caries-associated bacteria, microbial metabolic functions
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