Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy
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Many of the immune and metabolic changes occurring during normal pregnancy also describe metabolic syndrome. Gut microbiota can cause symptoms of metabolic syndrome in nonpregnant hosts. Here, to explore their role in pregnancy, we characterized fecal bacteria of 91 pregnant women of varying prepregnancy BMIs and gestational diabetes status and their infants. Similarities between infant-mother microbiotas increased with children's age, and the infant microbiota was unaffected by mother's health status. Gut microbiota changed dramatically from first (T1) to third (T3) trimesters, with vast expansion of diversity between mothers, an overall increase in Proteobacteria and Actinobacteria, and reduced richness. T3 stool showed strongest signs of inflammation and energy loss; however, microbiome gene repertoires were constant between trimesters. When transferred to germ-free mice, T3 microbiota induced greater adiposity and insulin insensitivity compared to T1. Our findings indicate that host-microbial interactions that impact host metabolism can occur and may be beneficial in pregnancy.
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Certain recurrent mammalian physiological states, such as non-hibernating bears and advanced pregnancy, produce a markedly altered microbiota with increased capacity to harvest dietary energy without metabolic derangement.
“Certain recurrent physiological states in mammals, such as the non-hibernating period in bears41 and advanced pregnancy42, result in a markedly altered microbiota with an increased capacity to harvest energy from the diet without metabolic derangement.”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [42]
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The gut microbiota and its role in the development of allergic disease: A wider perspective
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The gut microbiome is altered in a letrozole-induced mouse model of polycystic ovary syndrome
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Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?
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Links between the microbiome and bone
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Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease
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Steroids, stress and the gut microbiome-brain axis
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The developing gut microbiota and its consequences for health
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- Authors
- Koren, O., Goodrich, J. K., Cullender, T. C., Spor, A., Laitinen, K., Kling Bäckhed, H., Gonzalez, A., Werner, J. J., Angenent, L. T., Knight, R., Bäckhed, F., Isolauri, E., Salminen, S., & Ley, R. E.
- Affiliations
- Cornell University (US)
- University of Turku (FI)
- Howard Hughes Medical Institute (US)
- University of Gothenburg (SE)
- Turku University Hospital (FI)
- Corresponding author
- Ley, Ruth E.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 150
- Issue
- 3
- Pages
- 470-480
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3505857
- OpenAlex
- W2103761010
- Cited by
- 2,165
- References
- 60
- Citations by year
- 2026: 146 · 2025: 198 · 2024: 215 · 2023: 204 · 2022: 207 · 2021: 214 · 2020: 193 · 2019: 146 · 2018: 112 · 2017: 133 · 2016: 123 · 2015: 106 · 2014: 93 · 2013: 63 · 2012: 11
- FWCI
- 35.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 386 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- David and Lucile Packard Foundation
- Foundation for the National Institutes of Health
- Arnold and Mabel Beckman Foundation
- Hartwell Foundation
- National Institutes of Health (1dp2od007444-01)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK093595)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- gut microbiota, pregnancy, host-microbe interactions, metabolic syndrome, gestational diabetes mellitus, infant microbiome, maternal obesity, Proteobacteria, actinobacteria, adiposity, insulin resistance, germ-free mice, inflammation, energy metabolism
- MeSH terms
- Animals, Feces, Female, Germ-Free Life, Humans, Infant, Pregnancy, Proteobacteria, Metabolic Syndrome, Actinobacteria, Gastrointestinal Tract, Mice, Metagenome
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