Cited by 2,165Gut microbiota and healthOral microbiology and periodontitis researchInfant Nutrition and Health

Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy

Open access
Koren, Omry, Goodrich, Julia K., Cullender, Tyler C., Spor, Aymé, Laitinen, Kirsi, Kling Bäckhed, Helene, Gonzalez, Antonio, Werner, Jeffrey J. +6 more·2012·Cell

Abstract

Many of the immune and metabolic changes occurring during normal pregnancy also describe metabolic syndrome. Gut microbiota can cause symptoms of metabolic syndrome in nonpregnant hosts. Here, to explore their role in pregnancy, we characterized fecal bacteria of 91 pregnant women of varying prepregnancy BMIs and gestational diabetes status and their infants. Similarities between infant-mother microbiotas increased with children's age, and the infant microbiota was unaffected by mother's health status. Gut microbiota changed dramatically from first (T1) to third (T3) trimesters, with vast expansion of diversity between mothers, an overall increase in Proteobacteria and Actinobacteria, and reduced richness. T3 stool showed strongest signs of inflammation and energy loss; however, microbiome gene repertoires were constant between trimesters. When transferred to germ-free mice, T3 microbiota induced greater adiposity and insulin insensitivity compared to T1. Our findings indicate that host-microbial interactions that impact host metabolism can occur and may be beneficial in pregnancy.

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Crossref · 10.1016/j.cell.2012.07.008

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  • Certain recurrent mammalian physiological states, such as non-hibernating bears and advanced pregnancy, produce a markedly altered microbiota with increased capacity to harvest dietary energy without metabolic derangement.

    “Certain recurrent physiological states in mammals, such as the non-hibernating period in bears41 and advanced pregnancy42, result in a markedly altered microbiota with an increased capacity to harvest energy from the diet without metabolic derangement.”

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Research works printed but not linked: 1

  1. Carvalho FA Koren O Johansson M Nalbantoglu I Aitken JD Su Y Walters WA González Peña A Clemente JC Barnich N In Review Inability to manage Proteobacteria drives colitis in T5KO mice Cell Host Microbe In Review

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Authors
Koren, O., Goodrich, J. K., Cullender, T. C., Spor, A., Laitinen, K., Kling Bäckhed, H., Gonzalez, A., Werner, J. J., Angenent, L. T., Knight, R., Bäckhed, F., Isolauri, E., Salminen, S., & Ley, R. E.
Affiliations
  • Cornell University (US)
  • University of Turku (FI)
  • Howard Hughes Medical Institute (US)
  • University of Gothenburg (SE)
  • Turku University Hospital (FI)
Corresponding author
Ley, Ruth E.
Venue
Cell
Publisher
Elsevier BV
Published
2012-08
Volume
150
Issue
3
Pages
470-480
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2103761010
Cited by
2,165
References
60
Citations by year
2026: 146 · 2025: 198 · 2024: 215 · 2023: 204 · 2022: 207 · 2021: 214 · 2020: 193 · 2019: 146 · 2018: 112 · 2017: 133 · 2016: 123 · 2015: 106 · 2014: 93 · 2013: 63 · 2012: 11
FWCI
35.07
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion)
Funders
  • David and Lucile Packard Foundation
  • Foundation for the National Institutes of Health
  • Arnold and Mabel Beckman Foundation
  • Hartwell Foundation
  • National Institutes of Health (1dp2od007444-01)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK093595)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords
gut microbiota, pregnancy, host-microbe interactions, metabolic syndrome, gestational diabetes mellitus, infant microbiome, maternal obesity, Proteobacteria, actinobacteria, adiposity, insulin resistance, germ-free mice, inflammation, energy metabolism
MeSH terms
Animals, Feces, Female, Germ-Free Life, Humans, Infant, Pregnancy, Proteobacteria, Metabolic Syndrome, Actinobacteria, Gastrointestinal Tract, Mice, Metagenome

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