Low predictive power of clinical features for relapse prediction after antidepressant discontinuation in a naturalistic setting

Berwian, Isabel M.; Wenzel, Julia G.; Kuehn, Leonie; Schnuerer, Inga; Seifritz, Erich; Stephan, Klaas E.; Walter, Henrik; Huys, Quentin J. M.

doi:10.1038/s41598-022-13893-9

Low predictive power of clinical features for relapse prediction after antidepressant discontinuation in a naturalistic setting

The risk of relapse after antidepressant medication (ADM) discontinuation is high. Predictors of relapse could guide clinical decision-making, but are yet to be established. We assessed demographic and clinical variables in a longitudinal observational study before antidepressant discontinuation.…