Single-cell transcriptome and cell type-specific molecular pathways of human non-alcoholic steatohepatitis

Fred, Rikard G.; Steen Pedersen, Julie; Thompson, Jonatan J.; Lee, Julie; Timshel, Pascal N.; Stender, Stefan; Opseth Rygg, Marte; Gluud, Lise Lotte; Bjerregaard Kristiansen, Viggo; Bendtsen, Flemming; Hansen, Torben; Pers, Tune H.

doi:10.1038/s41598-022-16754-7

Single-cell transcriptome and cell type-specific molecular pathways of human non-alcoholic steatohepatitis

The aim of this study is to characterize cell type-specific transcriptional signatures in non-alcoholic steatohepatitis (NASH) to improve our understanding of the disease. We performed single-cell RNA sequencing on liver biopsies from 10 patients with NASH. We applied weighted gene co-expression …