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Cited by 3Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac electrophysiology and arrhythmias

Novel laparoscopic renal denervation immediately reduces atrial fibrillation inducibility: a swine model study

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Kwon, Soonil, Choi, Eue-Keun, Ahn, Hyo-Jeong, Lee, So-Ryoung, Oh, Seil, Kim, Si Hyun, Do, Minh-Tung, Han, Jang Hee +1 more·2023·Scientific Reports
DOI 10.1038/s41598-023-47077-wPMC PMC10640613
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Abstract

Catheter-based approaches may have inherent limitations in achieving effective renal denervation (RDN) and treatment of atrial fibrillation (AF). This study aimed to investigate the acute effects of novel laparoscopic RDN on modulating AF inducibility using a swine model. Four and five swine were randomly allocated to the sham and RDN groups, respectively. Each swine underwent measurement of the atrial effective refractory period (AERP) and AF induction tests using burst atrial pacing before and immediately after sham or RDN procedures with and without vagal nerve stimulation (VNS). A laparoscopic RDN procedure circumferentially ablated the renal nerves round the renal arteries using radiofrequency energy. There was no significant difference in the baseline AERP between the two groups (p > 0.05). Under VNS, AERP was significantly increased by 20 ms after laparoscopic RDN (95% CI = 0–30, p = 0.004). Compared to the sham group, the RDN group showed significantly reduced AF inducibility [OR (95% CI) = 0.32 (0.13–0.76) and 0.24 (0.11–0.57) with and without VNS, respectively]. After laparoscopic RDN, the duration of inducible AF episodes was significantly shortened from 28 (10–77) s to 7 (3–11) s (p < 0.001). The novel laparoscopic RDN can immediately reduce AF inducibility in a swine model.

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  • In a swine model, renal denervation significantly reduced the inducibility of atrial fibrillation and the duration of induced atrial fibrillation episodes immediately after denervation.

    “A study in a swine model in which the renal nerves were surgically ablated using a laparoscopic procedure found that RDN significantly reduced the inducibility of atrial fibrillation (OR = 0.32) and the duration of induced atrial fibrillation episodes (from 28 s to 7 s)161. Importantly, these findings were observed immediately after denervation, indicating that the effects of RDN on atrial”

    From Renal nerves in physiology, pathophysiology and interoception (2025) · cites this paper as [161]

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References 24 · Cited by 3

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Authors
Kwon, S., Choi, E.-K., Ahn, H.-J., Lee, S.-R., Oh, S., Kim, S. H., Do, M.-T., Han, J. H., & Jeong, C. W.
Affiliations
Seoul National University (KR)
Corresponding author
  • Choi, Eue-Keun
  • Jeong, Chang Wook
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2023-11-11
Volume
13
Issue
1
Pages
19679-19679
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-023-47077-w
PMC
PMC10640613
OpenAlex
W4388594559
Cited by
3
References
24
Citations by year
2025: 1 · 2024: 2
FWCI
0.59
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Research Foundation of Korea (2020R1F1A106740)
  • DeepQure, Inc, Seoul, Republic ok Korea (0620221670)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
atrial fibrillation, atrial fibrillation inducibility, atrial effective refractory period, vagus nerve stimulation, radiofrequency ablation, renal nerves, porcine model, catheter ablation
MeSH terms
Animals, Atrial Fibrillation, Denervation, Heart Atria, Kidney, Laparoscopy, Swine

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