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Cited by 12SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesPluripotent Stem Cells Research

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

Open access
Chau, Chiu Wang, To, Alex, Au-Yeung, Rex K. H., Tang, Kaiming, Xiang, Yang, Ruan, Degong, Zhang, Lanlan, Wong, Hera, Zhang, Shihui, Au, Man Ting, Chung, Seok, Song, Euijeong, Choi, Dong-Hee, Liu, Pentao, Yuan, Shuofeng, Wen, Chunyi, Sugimura, Ryohichi·2024·Scientific Reports
DOI 10.1038/s41598-024-59405-9PMC PMC11021416

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Abstract

SARS-CoV-2 provokes devastating tissue damage by cytokine release syndrome and leads to multi-organ failure. Modeling the process of immune cell activation and subsequent tissue damage is a significant task. Organoids from human tissues advanced our understanding of SARS-CoV-2 infection mechanisms though, they are missing crucial components: immune cells and endothelial cells. This study aims to generate organoids with these components. We established vascular immune organoids from human pluripotent stem cells and examined the effect of SARS-CoV-2 infection. We demonstrated that infections activated inflammatory macrophages. Notably, the upregulation of interferon signaling supports macrophages’ role in cytokine release syndrome. We propose vascular immune organoids are a useful platform to model and discover factors that ameliorate SARS-CoV-2-mediated cytokine release syndrome.

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  • Vascular-associated inflammatory readouts are relevant to inflammatory skin pathophysiology.

    “An important feature of the VSA system is its ability to assess vascular-associated inflammatory readouts, which are relevant to inflammatory skin pathophysiology [40][41][42] .”

    From Vascularized human skin assembloids model compartmental skin organization and immune responsiveness in vitro (2026) · cites this paper as [40]

    The Results report inflammatory gene signatures and IL6 in vascular immune organoids after SARS-CoV-2 infection, supporting the use of vascular-associated inflammatory readouts. The paper does not establish their relevance to inflammatory skin pathophysiology; its Discussion concerns COVID-19-related cytokine release and vascular damage, not skin disease. (LLM, conf=0.85)

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Research works printed but not linked: 32

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Metadata

Authors
Chau, C. W., To, A., Au-Yeung, R. K. H., Tang, K., Xiang, Y., Ruan, D., Zhang, L., Wong, H., Zhang, S., Au, M. T., Chung, S., Song, E., Choi, D.-H., Liu, P., Yuan, S., Wen, C., & Sugimura, R.
Affiliations
  • University of Hong Kong (HK)
  • Hong Kong Polytechnic University (HK)
  • Korea University (KR)
Corresponding author
  • Wen, Chunyi
  • Sugimura, Ryohichi
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2024-04-16
Volume
14
Issue
1
Pages
8781-8781
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-024-59405-9
PMC
PMC11021416
OpenAlex
W4394855728
Cited by
12
References
5
Citations by year
2026: 7 · 2025: 3 · 2024: 2
FWCI
4.15
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PolyU Institutional Research Archive (Hong Kong Polytechnic University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords
SARS-CoV-2, inflammatory macrophages, cytokine release syndrome, interferon signaling, human pluripotent stem cells, endothelial cells, multiple organ failure, COVID-19 pathogenesis, disease modeling
MeSH terms
Cytokine Release Syndrome, COVID-19, SARS-CoV-2, Humans, Macrophages, Organoids, Endothelial Cells

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