Cytokine release syndrome in severe COVID-19
Abstract
Lessons from arthritis and cell therapy in cancer patients point to therapy for severe disease
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Reports of hemophagocytosis and elevated cytokine levels, as well as beneficial effects of immunosuppressant agents, in severely ill Covid-19 patients suggest that cytokine storm may contribute to the pathogenesis of Covid-19.
“reports of hemophagocytosis and elevated cytokine levels — as well as beneficial effects of immunosuppressant agents — in affected patients, particularly those who are the most severely ill, suggest that cytokine storm may contribute to the pathogenesis of Covid-19.87,88”
From Cytokine storm (2020) · cites this paper as [87]
After a 1-year follow-up, 28% of SARS survivors presented decreased lung function and pulmonary fibrosis signs.
“After a 1-year follow-up, a study showed that 28% of the survivors presented decreased lung function and pulmonary fibrosis signs44,47,48.”
From More than 50 long-term effects of COVID-19: a systematic review and meta-analysis (2021) · cites this paper as [47]
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“Therefore, SARS-CoV-1 and SARS-CoV-2 infection activate both NF-κ B and STAT3, key elements of the IL-6 Amp, to cause cytokine storm (12, 13, 15, 349, 350).”
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“Inflammatory organ injury may occur in severe COVID-19, with a subset of patients having markedly elevated inflammatory markers such as C-reactive protein, ferritin, and interleukins 1 and 6.(6,15,16) Several therapeutic interventions to mitigate inflammatory organ injury have been proposed in viral pneumonia but the…”
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- Authors
- Moore, J. B., & June, C. H.
- Affiliations
- Walter Reed National Military Medical Center (US)
- University of Pennsylvania (US)
- Venue
- Science
- Published
- 2020-05
- Volume
- 368
- Issue
- 6490
- Pages
- 473-474
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3016661132
- Cited by
- 1,912
- References
- 15
- Citations by year
- 2026: 42 · 2025: 76 · 2024: 134 · 2023: 201 · 2022: 337 · 2021: 600 · 2020: 520
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA120409)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- cytokine release syndrome, severe COVID-19, SARS-CoV-2, cytokine storm, arthritis, cell therapy, cancer patients, immune-related adverse events
- MeSH terms
- Betacoronavirus, Receptors, Chimeric Antigen, Cytokine Release Syndrome, COVID-19, SARS-CoV-2, Interleukin-6 Inhibitors, C-Reactive Protein, Humans, Pneumonia, Viral, Respiratory Distress Syndrome, Interleukin-6, Immunotherapy, Adoptive, Coronavirus Infections, Severe Acute Respiratory Syndrome, Lymphohistiocytosis, Hemophagocytic, Pandemics, Antibodies, Monoclonal, Humanized
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