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Detection and genetic characterization of multidrug-resistant staphylococci isolated from public areas in an international airport
Open accessAbstract
The environmental realm has been acknowledged as a pivotal arena for the emergence and propagation of antimicrobial resistance. To further explore insight into antimicrobial resistance dynamics beyond clinical and veterinary settings, we embarked on an environmental surveillance initiative targeting the prevalence of antibiotic-resistant bacteria within the bustling confines of an international airport in Japan. Our findings illuminate a high prevalence of methicillin-resistant staphylococci (46.3%) on frequently contacted surfaces in the public domain. Notably, Staphylococcus haemolyticus and S. epidermidis emerged as the preeminent carriers of the mecA gene. Intriguingly, we encountered a virulent strain of livestock-associated MRSA harboring a PVL-positive ST1232 clone, CC398 lineage. Further scrutiny unveiled a repertoire of resistance mechanisms, the methicillin-resistant isolates exhibited two or more resistance genes conferring resistance against different types of antibiotics, including beta-lactams, macrolides, lincosamides, aminoglycosides, chloramphenicol, and fosfomycin. Revealing multidrug-resistant CoNS and a LA-MRSA across various surfaces in urban public areas unearths a looming public health hazard. Thus, implementation of molecular surveillance is imperative, augmenting our capacity for early detection and mitigation of the insidious spread and potential transfer of antibiotic resistance genes and virulence factors amidst urban settings, notably within pivotal nodes such as airports.
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Key S. haemolyticus sequence types included methicillin-resistant ST1, linked to NICUs previously, and ST49, associated with children and often resistant to methicillin.
“Of particular note, key S. haemolyticus STs included methicillin-resistant ST1, linked to NICUs previously34 and ST49, associated with children and often resistant to methicillin35,36.”
From Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants. (2025) · cites this paper as [36]
The Results section (Methicillin-resistant coagulase-negative Staphylococcus; page unavailable) identifies ST49 among methicillin-resistant S. haemolyticus isolates from airport surfaces. It does not link ST49 to children or establish that ST49 is often methicillin-resistant. The ST1/NICU clause has a separate citation in the citing sentence and is not attributed to this paper. (LLM, conf=0.86)
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Kiu, R., Darby, E. M., Alcon-Giner, C., Acuna-Gonzalez, A., Camargo, A., Lamberte, L. E., Phillips, S., Sim, K., Shaw, A. G., Clarke, P., et al. (2025) · Nature communications · doi:10.1038/s41467-025-62584-2 · Cited by 36
“Of particular note, key S. haemolyticus STs included methicillin-resistant ST1, linked to NICUs previously 34 and ST49, associated with children and often resistant to methicillin 35,36 .”
Metadata
- Authors
- Dewi, D. A. P. R., Khalifa, H. O., Khandar, H., Hisatsune, J., Kutuno, S., Yu, L., Hayashi, W., Kayama, S., Mason, C. E., Sugai, M., Suzuki, H., & Matsumoto, T.
- Affiliations
- Udayana University (ID)
- Kafrelsheikh University (EG)
- International University of Health and Welfare (JP)
- National Institute of Infectious Diseases (JP)
- Weill Cornell Medicine (US)
- Keio University (JP)
- Corresponding author
- Dewi, Dewa A.P. Rasmika
- Khalifa, Hazim O.
- Suzuki, Haruo
- ORCID
- Venue
- Scientific Reports
- Published
- 2024-11-12
- Volume
- 14
- Issue
- 1
- Pages
- 27738-27738
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC11557577
- OpenAlex
- W4404297738
- Cited by
- 7
- References
- 55
- Citations by year
- 2026: 4 · 2025: 3
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Scientific Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Japan Agency for Medical Research and Development (JP22fk0108132, JP23fk0108664)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Keywords
- multidrug-resistant staphylococci, methicillin-resistant staphylococci, mecA gene, Staphylococcus haemolyticus, Staphylococcus epidermidis, livestock-associated MRSA, Panton-Valentine leukocidin, CC398, coagulase-negative staphylococci, environmental surveillance, antimicrobial resistance genes, virulence factors, public health risk, molecular surveillance
- MeSH terms
- Anti-Bacterial Agents, Bacterial Proteins, Humans, Japan, Microbial Sensitivity Tests, Staphylococcal Infections, Staphylococcus, Drug Resistance, Multiple, Bacterial, Methicillin-Resistant Staphylococcus aureus, Airports
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