Functionalized Magnetic Nanoparticles with Deep Eutectic Solvents as Efficient Catalyst for the Green Synthesis of Dihydroquinazolinones
Open accessAbstract
-coated magnetic nanoparticles through a linker. The resulting nanomagnet-immobilized arginine/choline chloride designated as MNP@Arg/ChCl was characterized using FT-IR, XRD, TGA, VSM, and SEM techniques. The catalyst showed an irregular spherical morphology, and the mean particle diameter was determined to be about 39.9 nm. TGA analysis also confirmed that the catalyst remained thermally stable up to approximately 225 °C. MNP@Arg/ChCl demonstrated excellent catalytic activity in the solvent-free synthesis of 2,3-disubstituted-2,3-dihydroquinazolin-4(1 H)-one derivatives via a three-component reaction involving isatoic anhydride, amines, and aldehydes. The scope of this method was assessed using various aromatic aldehydes and aromatic amines. The 2,3-disubstituted-2,3-dihydroquinazolin-4(1 H)-one derivatives were obtained in yields ranging from 85% to 93% within a short reaction time. Due to the magnetization properties of MNP@Arg/ChCl, the catalyst can be easily separated from the reaction mixture and reused several times without significant loss of catalytic activity. This method is particularly attractive in the context of green chemistry due to its high catalytic efficiency, thermal stability, reusability, ease of recovery, and environmentally friendly features.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Anchoring DESs onto magnetic nanostructures broadens their potential applications in sustainable catalytic systems.
“thereby broadening their potential applications in sustainable catalytic systems [118].”
From Eco-Friendly Deep Eutectic Solvent-Based Extraction Technologies: A Comprehensive Review of Principles, Applications, and Comparative Insights (2026) · cites this paper as [118]
Anchoring DESs onto magnetic nanostructures can enhance material stability, facilitate recovery, and improve functional performance.
“Their findings showed that anchoring DESs onto magnetic nanostructures can enhance material stability, facilitate recovery, and improve functional performance, thereby broadening their potential applications in sustainable catalytic systems [118].”
From Eco-Friendly Deep Eutectic Solvent-Based Extraction Technologies: A Comprehensive Review of Principles, Applications, and Comparative Insights (2026) · cites this paper as [118]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Deep Eutectic Solvents (DESs) and Their Applications
Smith, E. L., Abbott, A. P., & Ryder, K. S. (2014) · Chemical Reviews · doi:10.1021/cr300162p · Cited by 7,378 · see citing works
Deep eutectic solvents: A review of fundamentals and applications
Hansen, B. B., Spittle, S., Chen, B., Poe, D., Zhang, Y., Klein, J. M., Horton, A., Adhikari, L., Zelovich, T., Doherty, B. W., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00385 · Cited by 3,422 · see citing works
Choi, Y. H., van Spronsen, J., Dai, Y., Verberne, M., Hollmann, F., Arends, I. W. C. E., Witkamp, G.-J., & Verpoorte, R. (2011) · Plant Physiology · doi:10.1104/pp.111.178426 · Cited by 1,368 · see citing works
Deep Eutectic Solvents: The Organic Reaction Medium of the Century
Alonso, D. A., Baeza, A., Chinchílla, R., Guillena, G., Pastor, I. M., & Ramón, D. J. (2016) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201501197 · Cited by 715 · see citing works
Dai, Y., Witkamp, G., Verpoorte, R., & Choi, Y. H. (2013) · Analytical Chemistry · doi:10.1021/ac400432p · Cited by 687 · see citing works
Liu, P., Hao, J., Mo, L., & Zhang, Z. (2015) · RSC Advances · doi:10.1039/c5ra05746a · Cited by 670 · see citing works
Multicomponent reactions (MCR) in medicinal chemistry: a patent review (2010-2020)
Younus, H. A., al‐Rashida, M., Hameed, A., et al. (2020) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2021.1858797 · Cited by 240 · see citing works
Zhang, Z., Lü, H., Yang, S.-H., et al. (2010) · Journal of Combinatorial Chemistry · doi:10.1021/cc100047j · Cited by 182 · see citing works
2,3-Dihydroquinazolin-4(1 H )-one as a privileged scaffold in drug design
Badolato, M., Aiello, F., & Neamati, N. (2018) · RSC Advances · doi:10.1039/c8ra02827c · Cited by 143 · see citing works
Alagarsamy, V., Solomon, V. R., & Murugan, M. (2007) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2007.04.001 · Cited by 117 · see citing works
Abdel‐Aziz, A. A. ‐., Abou-zeid, L. A., ElTahir, K. E. H., et al. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.05.066 · Cited by 113 · see citing works
Characterization and immobilization of trypsin on tannic acid modified Fe3O4 nanoparticles
Atacan, K., & Özacar, M. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.01.038 · Cited by 108 · see citing works
Wang, L., Hu, L., Shao, J., et al. (2008) · Journal of Fluorine Chemistry · doi:10.1016/j.jfluchem.2008.08.005 · Cited by 102 · see citing works
Magnetic deep eutectic solvents – Fundamentals and applications
Makoś‐Chełstowska, P., Kaykhaii, M., Płotka‐Wasylka, J., & de la Guárdia, M. (2022) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2022.120158 · Cited by 101 · see citing works
Towards a sustainable tomorrow: advancing green practices in organic chemistry
Sharma, S., Gallou, F., & Handa, S. (2024) · Green Chemistry · doi:10.1039/d4gc01826e · Cited by 90 · see citing works
Zhang, J., Ren, D., Ma, Y., et al. (2014) · Tetrahedron · doi:10.1016/j.tet.2014.05.059 · Cited by 89 · see citing works
Nguyen, T. T. N., Le, N. T., Nguyen, T. T., & Tran, P. H. (2019) · RSC Advances · doi:10.1039/c9ra08074k · Cited by 77 · see citing works
Antifungal quinazolinones from marine-derived Bacillus cereus and their preparation
Xu, Z., Zhang, Y., Fu, H., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.05.002 · Cited by 73 · see citing works
Lamei, N., Ezoddin, M., Ardestani, M. S., & Abdi, K. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-017-0547-8 · Cited by 73 · see citing works
Nandi, S., Jamatia, R., Sarkar, R., et al. (2022) · ChemistrySelect · doi:10.1002/slct.202201901 · Cited by 72 · see citing works
Razavi, N., & Akhlaghinia, B. (2015) · New Journal of Chemistry · doi:10.1039/c5nj02123e · Cited by 70 · see citing works
Tamoradi, T., Ghadermazi, M., & Ghorbani‐Choghamarani, A. (2018) · Catalysis Letters · doi:10.1007/s10562-018-2311-x · Cited by 67 · see citing works
Barmak, A., Niknam, K., & Mohebbi, G. (2019) · ACS Omega · doi:10.1021/acsomega.9b01906 · Cited by 60 · see citing works
Tajbakhsh, M., Farhang, M., Hosseinzadeh, R., et al. (2014) · RSC Advances · doi:10.1039/c4ra03333g · Cited by 59 · see citing works
Self-citationHydrogen bonding motifs of protein side chains: Descriptions of binding of arginine and amide groups
Shimoni, L., & GLUSKER, J. P. (1995) · Protein Science · doi:10.1002/pro.5560040109 · Cited by 58 · see citing works
Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors
Birch, H. L., Buckley, G. M., Davies, N., et al. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.06.108 · Cited by 57 · see citing works
Yu, D., Mou, H., Zhao, X., Wang, Y., & Mu, T. (2019) · Chemistry - An Asian Journal · doi:10.1002/asia.201900990 · Cited by 52 · see citing works
Amirnejat, S., Nosrati, A., Javanshir, S., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.02.212 · Cited by 48 · see citing works
Akbarian, M., Sanchooli, E., Oveisi, A. R., et al. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.115228 · Cited by 48 · see citing works
Azizi, N., & Edrisi, M. (2016) · Microporous and Mesoporous Materials · doi:10.1016/j.micromeso.2016.11.009 · Cited by 46 · see citing works
Inaloo, I. D., Majnooni, S., & Esmaeilpour, M. (2018) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201800581 · Cited by 43 · see citing works
Tavakol, H., & Keshavarzipour, F. (2017) · Applied Organometallic Chemistry · doi:10.1002/aoc.3811 · Cited by 40 · see citing works
Inaloo, I. D., & Majnooni, S. (2019) · New Journal of Chemistry · doi:10.1039/c9nj02810b · Cited by 40 · see citing works
Valipour, Z., Hosseinzadeh, R., Sarrafi, Y., et al. (2023) · Organic Preparations and Procedures International · doi:10.1080/00304948.2023.2232917 · Cited by 39 · see citing works
Self-citation“Inverted” Deep Eutectic Solvents Based on Host‐Guest Interactions
Yu, D., Mou, H., Fu, H., Lan, X., Wang, Y., & Mu, T. (2019) · Chemistry - An Asian Journal · doi:10.1002/asia.201901365 · Cited by 35 · see citing works
Falcini, C., & de Gonzalo, G. (2024) · Catalysts · doi:10.3390/catal14020120 · Cited by 34 · see citing works
Hosseinzadeh, R., Zarei, S., Valipour, Z., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e37170 · Cited by 32 · see citing works
Self-citationYang, Y., Fu, R., Liu, Y., et al. (2020) · Tetrahedron · doi:10.1016/j.tet.2020.131312 · Cited by 30 · see citing works
Mohammadi, A. A., Rohi, H., & Soorki, A. A. (2013) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.1075 · Cited by 29 · see citing works
Jannatabadi, S. A., Hosseinzadeh, R., & Maleki, B. (2024) · Results in Chemistry · doi:10.1016/j.rechem.2024.101848 · Cited by 28 · see citing works
Self-citationBakhtiarian, M., & Khodaei, M. M. (2022) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2022.128569 · Cited by 26 · see citing works
Fanimoghadam, H., Dekamin, M. G., & Rostami, N. (2022) · Research on Chemical Intermediates · doi:10.1007/s11164-022-04736-3 · Cited by 26 · see citing works
Anizadeh, M. R., Zolfigol, M. A., Torabi, M., Yarie, M., & Notash, B. (2022) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2022.120016 · Cited by 25 · see citing works
Mirjalili, B. B. F., Bamoniri, A., & Azad, S. (2016) · Journal of the Iranian Chemical Society · doi:10.1007/s13738-016-0956-1 · Cited by 24 · see citing works
Bagherzadeh, N., Sardarian, A. R., & Inaloo, I. D. (2021) · New Journal of Chemistry · doi:10.1039/d1nj01827b · Cited by 21 · see citing works
Zamani, P., Ozdemir, J., Ha, Y., Benamara, M., Kuchuk, A., Wang, T., Chen, J., Khosropour, A. R., & Beyzavi, M. H. (2018) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201800743 · Cited by 20 · see citing works
Co-aminobenzamid@Al-SBA-15: a favorable catalyst in synthesis of 2,3-dihydroquinazolin-4(1H)-ones
Safaei‐Ghomi, J., Teymuri, R., & Bakhtiari, A. (2019) · BMC Chemistry · doi:10.1186/s13065-019-0517-7 · Cited by 20 · see citing works
Karimi‐Nami, R., Keypour, H., Rabiei, K., et al. (2023) · Polycyclic aromatic compounds · doi:10.1080/10406638.2023.2244632 · Cited by 20 · see citing works
Rabiei, K., Pouramiri, B., Neshati, M., et al. (2023) · Journal of Organometallic Chemistry · doi:10.1016/j.jorganchem.2023.122888 · Cited by 20 · see citing works
Hosseinzadeh, R., Mavvaji, M., Tajbakhsh, M., et al. (2018) · Journal of the Iranian Chemical Society · doi:10.1007/s13738-017-1288-5 · Cited by 15 · see citing works
Self-citationSynthesis of new hybrid pyridines catalyzed by Fe3O4@SiO2@urea-riched ligand/Ch-Cl
Zarei, N., Zolfigol, M. A., Torabi, M., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-35849-3 · Cited by 15 · see citing works
Mohammadkhani, Z., Rabiei, K., Keypour, H., et al. (2023) · Journal of Organometallic Chemistry · doi:10.1016/j.jorganchem.2023.122822 · Cited by 15 · see citing works
Roustaie, E., Tajbakhsh, M., & Hosseinzadeh, R. (2023) · Journal of Organometallic Chemistry · doi:10.1016/j.jorganchem.2023.122885 · Cited by 14 · see citing works
Self-citationMashhadi, E., & Safaei‐Ghomi, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-52749-2 · Cited by 14 · see citing works
Poudapally, S., Gurram, V., Garlapati, R., et al. (2017) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.2815 · Cited by 12 · see citing works
Rahimi, S., Nezhad, S. M., Zare, E. N., et al. (2023) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2023.111556 · Cited by 12 · see citing works
Bollini, M., Bruno, A. M., Niño, M. E., Casal, J. J., Sasiambarrena, L. D., Valdez, D. A. G., Battini, L., Puente, V., & Lombardo, M. E. (2018) · Medicinal Chemistry · doi:10.2174/1573406414666181005145042 · Cited by 11 · see citing works
Karkhah, M. K., Kefayati, H., & Shariati, S. (2019) · Applied Organometallic Chemistry · doi:10.1002/aoc.5139 · Cited by 11 · see citing works
Benrashid, A., Habibi, D., & Beiranvand, M. (2024) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2024.125504 · Cited by 9 · see citing works
Heterogeneous Catalysis in the Synthesis of Nitrogen‐Containing Heterocyclics
Rajendran, A., Anand, S., Sunajadevi, K. R. P., et al. (2024) · ChemistrySelect · doi:10.1002/slct.202403656 · Cited by 8 · see citing works
Mane, R. R., Yaraguppi, D. A., Ashok, A. K., et al. (2024) · Research on Chemical Intermediates · doi:10.1007/s11164-024-05305-6 · Cited by 6 · see citing works
Hutait, S., Maikhuri, V. K., Pandey, A. K., et al. (2024) · ChemistrySelect · doi:10.1002/slct.202304087 · Cited by 4 · see citing works
Hosseinzadeh, R., Karimi, S., Valipour, Z., et al. (2024) · Organic Preparations and Procedures International · doi:10.1080/00304948.2024.2346706 · Cited by 4 · see citing works
Self-citationRode, N. R., Tantray, A. A., Shelar, A. V., et al. (2023) · Research on Chemical Intermediates · doi:10.1007/s11164-023-05197-y · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [45]Sourkouhi, R. P., Dekamin, M. G., Valiey, E. & Dohendou, M. Magnetic decorated 5-sulfosalicylic acid grafted to chitosan: A solid acid organocatalyst for green synthesis of Quinazoline derivatives. Carbohydr. Polym. Technol. Appl. 7, 100420 (2024).
Cited by
Sorted by citations
Alahmadi, S. M., & Abu-Dief, A. M. (2026) · Sustainable Chemistry · doi:10.3390/suschem7030033 · Cited by 1 · see citing works
“Their findings showed that anchoring DESs onto magnetic nanostructures can enhance material stability, facilitate recovery, and improve functional performance, thereby broadening their potential applications in sustainable catalytic systems [118].”
- Authors
- Valipour, Z., Hosseinzadeh, R., Sarrafi, Y., & Maleki, B.
- Affiliations
- University of Mazandaran (IR)
- Corresponding author
- Hosseinzadeh, Rahman
- Venue
- Scientific Reports
- Published
- 2025-11-17
- Volume
- 15
- Issue
- 1
- Pages
- 40184-40184
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC12623933
- OpenAlex
- W4416291432
- Cited by
- 7
- References
- 64
- Citations by year
- 2026: 7
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Scientific Reports (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Mazandaran
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Multicomponent Synthesis of Heterocycles
- Physical Sciences › Chemistry › Organic Chemistry › Quinazolinone synthesis and applications
- Physical Sciences › Chemical Engineering › Catalysis › Ionic liquids properties and applications
- Keywords
- magnetic nanoparticles, deep eutectic solvents, dihydroquinazolinones, three-component reaction, isatoic anhydride, green synthesis, heterogeneous catalysis, catalyst immobilization, L-arginine, choline chloride, catalyst reusability, solvent-free synthesis, aromatic amines, aromatic aldehydes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review