The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
3D bioprinting for reconstituting the cancer microenvironment
Open accessAbstract
The cancer microenvironment is known for its complexity, both in its content as well as its dynamic nature, which is difficult to study using two-dimensional (2D) cell culture models. Several advances in tissue engineering have allowed more physiologically relevant three-dimensional (3D) in vitro cancer models, such as spheroid cultures, biopolymer scaffolds, and cancer-on-a-chip devices. Although these models serve as powerful tools for dissecting the roles of various biochemical and biophysical cues in carcinoma initiation and progression, they lack the ability to control the organization of multiple cell types in a complex dynamic 3D architecture. By virtue of its ability to precisely define perfusable networks and position of various cell types in a high-throughput manner, 3D bioprinting has the potential to more closely recapitulate the cancer microenvironment, relative to current methods. In this review, we discuss the applications of 3D bioprinting in mimicking cancer microenvironment, their use in immunotherapy as prescreening tools, and overview of current bioprinted cancer models.
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Cites
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Cited by
Fabrication of Biomedical Scaffolds Using Biodegradable Polymers.
Kirillova, A., Yeazel, T. R., Asheghali, D., Petersen, S. R., Dort, S., Gall, K., & Becker, M. L. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01200 · Cited by 368
Johnson, P. A., Menegatti, S., Chambers, A. C., Alibhai, D., Collard, T. J., Williams, A. C., Bayley, H., & Perriman, A. W. (2023) · Biofabrication · doi:10.1088/1758-5090/ac999f · Cited by 16
Metadata
- Authors
- Datta, P., Dey, M., Ataie, Z., Unutmaz, D., & Ozbolat, I. T.
- Venue
- npj Precision Oncology
- Published
- 2020-07-27
- Volume
- 4
- Issue
- 1
- Pages
- 18-18
- ISSN
- 2397-768X (ISSN-L)
- OpenAlex
- W3044874253
- Cited by
- 304
- References
- 102
- FWCI
- 12.75
- Type
- journal article
- Language
- en
- Open access
- gold
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- Datta, P., Dey, M., Ataie, Z., Unutmaz, D., & Ozbolat, I. T. (2020). 3D bioprinting for reconstituting the cancer microenvironment. npj Precision Oncology. https://doi.org/10.1038/s41698-020-0121-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
