A comprehensive overview of liquid biopsy applications in pediatric solid tumors

Cancer statistics, 2023

Siegel, R. L., Miller, K. D., Wagle, N. S., & Jemal, A. (2023) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21763 · Cited by 16,303

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

Bettegowda, C., Sausen, M., Leary, R. J., Kinde, I., Wang, Y., Agrawal, N., Bartlett, B. R., Wang, H., Luber, B., Alani, R. M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007094 · Cited by 5,067

Cancer treatment and survivorship statistics, 2019

Miller, K. D., Nogueira, L., Mariotto, A. B., Rowland, J. H., Yabroff, K. R., Alfano, C. M., Jemal, A., Kramer, J. L., & Siegel, R. L. (2019) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21565 · Cited by 4,347

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

Doll, R., & Peto, R. (1981) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/66.6.1192 · Cited by 3,927

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

Peto, R. (1983) · Springer eBooks · doi:10.1007/978-1-4757-1117-2_30 · Cited by 3,504

The tumor microenvironment

Anderson, N. M., & Simon, M. C. (2020) · Current Biology · doi:10.1016/j.cub.2020.06.081 · Cited by 2,718

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

Dawson, S.-J., Tsui, D. W. Y., Murtaza, M., Biggs, H., Rueda, O. M., Chin, S.-F., Dunning, M. J., Gale, D., Forshew, T., Mahler-Araujo, B., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1213261 · Cited by 2,207

The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report

Cohn, S. L., Pearson, A. D. J., London, W. B., Monclair, T. F., Ambros, P. F., Brodeur, G. M., Faldum, A., Hero, B., Iehara, T., Machin, D., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.16.6785 · Cited by 1,915

The landscape of genomic alterations across childhood cancers

ICGC PedBrain-Seq Project, Gröbner, S. N., ICGC MMML-Seq Project, Worst, B. C., Weischenfeldt, J., Buchhalter, I., Kleinheinz, K., Rudneva, V. A., Johann, P. D., Balasubramanian, G. P., et al. (2018) · Nature · doi:10.1038/nature25480 · Cited by 1,572

Neuroblastoma

Matthay, K. K., Maris, J. M., Schleiermacher, G., Nakagawara, A., Mackall, C. L., Diller, L., & Weiss, W. A. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.78 · Cited by 1,496

Germline Mutations in Predisposition Genes in Pediatric Cancer

Zhang, J., Walsh, M. F., Wu, G., Edmonson, M. N., Gruber, T. A., Easton, J., Hedges, D., Ma, X., Zhou, X., Yergeau, D. A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1508054 · Cited by 1,345

A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors

Voorhoeve, P. M., le Sage, C., Schrier, M., Gillis, A., Stoop, H., Nagel, R., Liu, Y. P., van Duijse, J., Drost, J., Griekspoor, A., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.037 · Cited by 1,266

Liquid biopsy enters the clinic — implementation issues and future challenges

Ignatiadis, M., Sledge, G. W., & Jeffrey, S. S. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00457-x · Cited by 1,191

MicroRNA and cancer

Jansson, M., & Lund, A. H. (2012) · Molecular Oncology · doi:10.1016/j.molonc.2012.09.006 · Cited by 1,148

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

Tomasetti, C., Li, L., & Vogelstein, B. (2017) · Science · doi:10.1126/science.aaf9011 · Cited by 1,143

Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling

Chaudhuri, A. A., Chabon, J. J., Lovejoy, A. F., Newman, A. M., Stehr, H., Azad, T. D., Khodadoust, M. S., Esfahani, M. S., Liu, C. L., Zhou, L., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0716 · Cited by 1,105

Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer

Tie, J., Cohen, J. D., Lahouel, K., Lo, S. N., Wang, Y., Kosmider, S., Wong, R., Shapiro, J., Lee, M., Harris, S., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2200075 · Cited by 1,091

Osteosarcoma

Ritter, J., & Bielack, S. (2010) · Annals of Oncology · doi:10.1093/annonc/mdq276 · Cited by 1,050

Liquid Biopsy: From Discovery to Clinical Application

Alix‐Panabières, C., & Pantel, K. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1311 · Cited by 1,006

Epidemiology of childhood cancer

Kaatsch, P. (2010) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2010.02.003 · Cited by 981

Liquid biopsy: current technology and clinical applications

Nikanjam, M., Kato, S., & Kurzrock, R. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01351-y · Cited by 963

Rhabdomyosarcoma

Skapek, S. X., Ferrari, A., Gupta, A. A., Lupo, P. J., Butler, E. B., SHIPLEY, J. M., Barr, F. G., & Hawkins, D. S. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0051-2 · Cited by 909

Ewing sarcoma

Grünewald, T. G. P., Cidre-Aranaz, F., Surdez, D., Tomazou, E. M., de Álava, E., Kovar, H., Sorensen, P. H., Delattre, O., & Dirksen, U. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0003-x · Cited by 873

Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments

Lone, S. N., Nisar, S., Masoodi, T., Singh, M. K., Rizwan, A., Hashem, S., El-Rifai, W. M., Bedognetti, D., Batra, S. K., Haris, M., et al. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01543-7 · Cited by 866

ctDNA guiding adjuvant immunotherapy in urothelial carcinoma

Powles, T. B., Assaf, Z. J. F., Davarpanah, N. N., Banchereau, R., Szabados, B. E., Yuen, K. C. Y., Grivas, P. D., Hussain, M., Oudard, S. M., Gschwend, J. E., et al. (2021) · Nature · doi:10.1038/s41586-021-03642-9 · Cited by 679

Osteosarcoma

Beird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00409-y · Cited by 660

Enzymatic methyl sequencing detects DNA methylation at single-base resolution from picograms of DNAPreprint

Vaisvila, R., Ponnaluri, V. K. C., Sun, Z., Langhorst, B. W., Saleh, L., Guan, S., Dai, N., Campbell, M. A., Sexton, B. S., Marks, K., et al. (2021) · Genome Research · doi:10.1101/gr.266551.120 · Cited by 533

Fusion Gene–Negative Alveolar Rhabdomyosarcoma Is Clinically and Molecularly Indistinguishable From Embryonal Rhabdomyosarcoma

Williamson, D. S., Missiaglia, E., de Reyniès, A., Pierron, G., Thuille, B., Palenzuela, G., Thway, K., Orbach, D. H., Lae, M. E., Fréneaux, P., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.3814 · Cited by 501

Prognostic Factors in Metastatic Rhabdomyosarcomas: Results of a Pooled Analysis From United States and European Cooperative Groups

Oberlin, O., Rey, A., Lyden, E. R., Bisogno, G., Stevens, M. C. G., Meyer, W. H., Carli, M., & Anderson, J. R. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.14.7207 · Cited by 483

Loss of Heterozygosity for Chromosomes 1p and 16q Is an Adverse Prognostic Factor in Favorable-Histology Wilms Tumor: A Report From the National Wilms Tumor Study Group

Grundy, P. E., Breslow, N. E., Li, S., Perlman, E. J., Beckwith, J. B., Ritchey, M. L., Shamberger, R. C., Haase, G. M., D’Angio, G. J., Donaldson, M. H., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.01.2799 · Cited by 476

Evaluating intrinsic and non-intrinsic cancer risk factors

Wu, S., Zhu, W., Thompson, P. A., & Hannun, Y. A. (2018) · Nature Communications · doi:10.1038/s41467-018-05467-z · Cited by 473

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

Erkizan, H. V., Kong, Y., Merchant, M. S., Schlottmann, S., Barber-Rotenberg, J. S., Yuan, L., Abaan, O. D., Chou, T.-F., Dakshanamurthy, S., Brown, M. L., et al. (2009) · Nature Medicine · doi:10.1038/nm.1983 · Cited by 467

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma

Sausen, M., Leary, R. J., Jones, S., Wu, J., Reynolds, C. P., Liu, X., Blackford, A. L., Parmigiani, G., Diaz, L. A., Papadopoulos, N., et al. (2012) · Nature Genetics · doi:10.1038/ng.2493 · Cited by 415

Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP–RTSG 2016 protocol

on behalf of the International Society of Paediatric Oncology — Renal Tumour Study Group (SIOP–RTSG), van den Heuvel‐Eibrink, M. M., Hol, J. A., Pritchard‐Jones, K., van Tinteren, H., Furtwängler, R., Verschuur, A. C., Vujanic, G. M., Leuschner, I., Brok, J. S., et al. (2017) · Nature Reviews Urology · doi:10.1038/nrurol.2017.163 · Cited by 390

Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study

Tie, J., Cohen, J. D., Wang, Y., Li, L., Christie, M., Simons, K., Elsaleh, H., Kosmider, S., Wong, R., Yip, D., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315852 · Cited by 385

Soft tissue sarcoma across the age spectrum: A population‐based study from the surveillance epidemiology and end results database

Ferrari, A., Sultan, I. Y., Huang, T. T., Galindo, C. R., Shehadeh, A. M., Meazza, C., Ness, K. K., Casanova, M., & Spunt, S. L. (2011) · Pediatric Blood & Cancer · doi:10.1002/pbc.23252 · Cited by 376

A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor

Gadd, S., Huff, V., Walz, A. L., Ooms, A. H. A. G., Armstrong, A. E., Gerhard, D. S., Smith, M. A., Auvil, J. M. G., Meerzaman, D. M., Chen, Q.-R., et al. (2017) · Nature Genetics · doi:10.1038/ng.3940 · Cited by 369

Successful Therapy Reduction and Intensification for Childhood Acute Lymphoblastic Leukemia Based on Minimal Residual Disease Monitoring: Study ALL10 From the Dutch Childhood Oncology Group

Pieters, R., de Groot‐Kruseman, H., van der Velden, V., Fiocco, M. F., van den Berg, H., de Bont, E., Egeler, R. M., Hoogerbrugge, P. M., Kaspers, G. J. L., van der Schoot, C. E., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.64.6364 · Cited by 366

Serum Levels of MicroRNA-371a-3p (M371 Test) as a New Biomarker of Testicular Germ Cell Tumors: Results of a Prospective Multicentric Study

Dieckmann, K., Radtke, A., Géczi, L., Matthies, C., Anheuser, P., Eckardt, U., Sommer, J. U., Zengerling, F., Trenti, E., Pichler, R., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.18.01480 · Cited by 356

Comparing children and adults with synovial sarcoma in the Surveillance, Epidemiology, and End Results program, 1983 to 2005

Sultan, I. Y., Galindo, C. R., Saab, R. H., Yasir, S., Casanova, M., & Ferrari, A. (2009) · Cancer · doi:10.1002/cncr.24424 · Cited by 344

Human germ cell tumours from a developmental perspective

Oosterhuis, J. W., & Looijenga, L. H. J. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0178-9 · Cited by 339

Malignant Germ Cell Tumors Display Common MicroRNA Profiles Resulting in Global Changes in Expression of Messenger RNA Targets

Palmer, R. D., Murray, M. J., Saini, H. K., van Dongen, S., Abreu‐Goodger, C., Muralidhar, B., Pett, M. R., Thornton, C. M., Nicholson, J. C., Enright, A. J., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3301 · Cited by 286

EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells.

Tanaka, K., Iwakuma, T., Harimaya, K., Sato, H., & Iwamoto, Y. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119152 · Cited by 283

Circulating tumor cell isolation, culture, and downstream molecular analysis

Sharma, S., Zhuang, R., Long, M., Pavlović, M. D., Kang, Y., Ilyas, A., & Asghar, W. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.03.007 · Cited by 247

White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer

Leal, A., van Grieken, N. C. T., Palsgrove, D. N., Phallen, J. A., Medina, J. E., Hruban, C., Broeckaert, M. A. M., Anagnostou, V., Adleff, V., Bruhm, D. C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14310-3 · Cited by 245

High‐throughput microRNAome analysis in human germ cell tumours

Gillis, A., Stoop, H., Hersmus, R., Oosterhuis, J. W., Sun, Y., Chen, C., Guenther, S. M., Sherlock, J. K., Veltman, I. M., Baeten, J., et al. (2007) · The Journal of Pathology · doi:10.1002/path.2230 · Cited by 240

Environmental factors inducing human cancers.

Parsa, N. (2012) · Europe PMC (PubMed Central) · Cited by 236

The genomic landscape of pediatric cancers: Implications for diagnosis and treatment

Sweet-Cordero, A., & Biegel, J. A. (2019) · Science · doi:10.1126/science.aaw3535 · Cited by 236

Comparison of Anticancer Drug Toxicities: Paradigm Shift in Adverse Effect Profile

Basak, D., Arrighi, S., Darwiche, Y., & Deb, S. (2021) · Life · doi:10.3390/life12010048 · Cited by 235

Identification of MicroRNAs From the miR-371∼373 and miR-302 Clusters as Potential Serum Biomarkers of Malignant Germ Cell Tumors

Murray, M. J., Halsall, D. J., Hook, C. E., Williams, D., Nicholson, J. C., & Coleman, N. (2010) · American Journal of Clinical Pathology · doi:10.1309/ajcpoe11keyzcjht · Cited by 227

Advances in the translational genomics of neuroblastoma: From improving risk stratification and revealing novel biology to identifying actionable genomic alterations

Bosse, K. R., & Maris, J. M. (2015) · Cancer · doi:10.1002/cncr.29706 · Cited by 222

Hepatoblastoma and Pediatric Hepatocellular Carcinoma: An Update

Ranganathan, S., Lopez-Terrada, D. H., & Alaggio, R. (2019) · Pediatric and Developmental Pathology · doi:10.1177/1093526619875228 · Cited by 221

Osteosarcoma

Eaton, B. R., Schwarz, R., Vatner, R. E., Yeh, B. K., Claude, L., Indelicato, D. J., & Laack, N. N. (2020) · Pediatric Blood & Cancer · doi:10.1002/pbc.28352 · Cited by 216

Increased Risk of Systemic Relapses Associated With Bone Marrow Micrometastasis and Circulating Tumor Cells in Localized Ewing Tumor

Schleiermacher, G., Peter, M., Oberlin, O., Philip, T. O., Rubie, H., Mechinaud, F. M., Sommelet-Olive, D., Landman‐Parker, J., Bours, D., Michon, J. M., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2003.03.006 · Cited by 211

Cell-free DNA analysis in current cancer clinical trials: a review

Cisneros-Villanueva, M., Pérez, L. H., Ríos-Romero, M., Cedro‐Tanda, A., Ruiz-Villavicencio, C. A., Page, K., Hastings, R. K., Fernández-García, D., Allsopp, R. C., Fonseca-Montaño, M. A., et al. (2022) · British Journal of Cancer · doi:10.1038/s41416-021-01696-0 · Cited by 205

Rhabdomyosarcoma

Dasgupta, R. A., Fuchs, J., & Rodeberg, D. A. (2016) · Seminars in Pediatric Surgery · doi:10.1053/j.sempedsurg.2016.09.011 · Cited by 201

Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden

Peneder, P., Stütz, A. M., Surdez, D., Krumbholz, M., Semper, S., Chicard, M., Sheffield, N. C., Pierron, G., Lapouble, E., Tötzl, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23445-w · Cited by 200

Clonal Hematopoiesis in Liquid Biopsy: From Biological Noise to Valuable Clinical Implications

Chan, H. T., Chin, Y. M., Nakamura, Y., & Low, S. (2020) · Cancers · doi:10.3390/cancers12082277 · Cited by 190

The present and future of serum diagnostic tests for testicular germ cell tumours

Murray, M. J., Huddart, R. A., & Coleman, N. (2016) · Nature Reviews Urology · doi:10.1038/nrurol.2016.170 · Cited by 189

Incidence of childhood renal tumours: An international population‐based study

Nakata, K., Colombet, M., Stiller, C. A., Pritchard‐Jones, K., Steliarova‐Foucher, E., & Contributors, I. (2020) · International Journal of Cancer · doi:10.1002/ijc.33147 · Cited by 183

Sensitive detection of rare circulating neuroblastoma cells by the reverse transcriptase-polymerase chain reaction.

Mattano, L. A., Moss, T. J., & Emerson, S. G. (1992) · PubMed · Cited by 181

Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells

Satelli, A., Mitra, A., Cutrera, J. J., Devarie, M., Xia, X., Ingram, D. R., Dibra, D., Somaiah, N., Torres, K. E., Ravi, V., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1739 · Cited by 173

Extracellular vesicle-mediated delivery of miR-101 inhibits lung metastasis in osteosarcoma

Zhang, K., Dong, C., Chen, M., Yang, T.-T., Wang, X., Gao, Y., Wang, L., Wen, Y., Chen, G., Wang, X., et al. (2019) · Theranostics · doi:10.7150/thno.33482 · Cited by 173

Osimertinib benefit inEGFR-mutant NSCLC patients withT790M-mutation detected by circulating tumour DNA

Remón, J., Caramella, C., Jovelet, C., Lacroix, L., Lawson, A. R. J., Smalley, S., Howarth, K., Gale, D. G., Green, E., Plagnol, V., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx017 · Cited by 167

Compare and contrast: pediatric cancer versus adult malignancies

Kattner, P., Strobel, H., Khoshnevis, N., Grunert, M., Bartholomae, S., Pruss, M., Fitzel, R., Halatsch, M., Schilberg, K., Siegelin, M. D., et al. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09836-y · Cited by 166

Refinement of risk stratification for childhood rhabdomyosarcoma using FOXO1 fusion status in addition to established clinical outcome predictors: A report from the Children's Oncology Group

Hibbitts, E., Chi, Y., Hawkins, D. S., Barr, F. G., Bradley, J. A., Dasgupta, R. A., Meyer, W. H., Rodeberg, D. A., Rudzinski, E. R., Spunt, S. L., et al. (2019) · Cancer Medicine · doi:10.1002/cam4.2504 · Cited by 162

Targeted serum miRNA (TSmiR) test for diagnosis and follow‐up of (testicular) germ cell cancer patients: A proof of principle

Gillis, A., Rijlaarsdam, M. A., Eini, R., Dorssers, L. C. J., Biermann, K., Murray, M. J., Nicholson, J. C., Coleman, N., Dieckmann, K., Belge, G., et al. (2013) · Molecular Oncology · doi:10.1016/j.molonc.2013.08.002 · Cited by 159

Quantitative Tumor Cell Content of Bone Marrow and Blood as a Predictor of Outcome in Stage IV Neuroblastoma: A Children’s Cancer Group Study

Seeger, R. C., Reynolds, C. P., Gallego, R., Stram, D. O., Gerbing, R. B., & Matthay, K. K. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.24.4067 · Cited by 159

Diagnostic and prognostic value of circulating miR-21 for cancer: A systematic review and meta-analysis

Wang, Y., Gao, X., Wei, F., Zhang, X., Yu, J., Zhao, H., Sun, Q., Fan, Y. L., Yan, C., Li, H., et al. (2013) · Gene · doi:10.1016/j.gene.2013.09.038 · Cited by 158

The current landscape of rhabdomyosarcomas: an update

Leiner, J., & Loarer, F. L. (2019) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-019-02676-9 · Cited by 152

Whole-Exome Sequencing of Cell-Free DNA Reveals Temporo-spatial Heterogeneity and Identifies Treatment-Resistant Clones in Neuroblastoma

Chicard, M., Daage, L. C., Clément, N., Danzon, A., Bohec, M., Bernard, V., Baulande, S., Bellini, A., Deveau, P., Pierron, G., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1586 · Cited by 150

Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children’s Oncology Group

Shulman, D. S., Klega, K., Imamovic-Tuco, A., Clapp, A., Nag, A., Thorner, A. R., Van Allen, E., Ha, G., Lessnick, S. L., Gorlick, R., et al. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0212-9 · Cited by 149

A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours

Murray, M. J., Bell, E., Raby, K. L., Rijlaarsdam, M. A., Gillis, A., Looijenga, L. H. J., Brown, H. J., Destenaves, B., Nicholson, J. C., & Coleman, N. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.429 · Cited by 148

Gene fusions in soft tissue tumors: Recurrent and overlapping pathogenetic themes

Mertens, F., Antonescu, C. R., & Mitelman, F. (2015) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22335 · Cited by 145

Human Germ Cell Tumors are Developmental Cancers: Impact of Epigenetics on Pathobiology and Clinic

Lobo, J., Gillis, A., Jerónimo, C., Henrique, R., & Looijenga, L. H. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020258 · Cited by 144

Alternative and complementary cancer therapies

Cassileth, B. R., & Chapman, C. C. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960315)77:6 · Cited by 142

Clear cell sarcoma of the kidney: A review

Gooskens, S. L. M., Furtwängler, R., Vujanic, G. M., Dome, J. S., Graf, N. M., & van den Heuvel‐Eibrink, M. M. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2012.04.009 · Cited by 141

Harmonizing Cell-Free DNA Collection and Processing Practices through Evidence-Based Guidance

Greytak, S. R., Engel, K. B., Parpart-Li, S., Murtaza, M., Bronkhorst, A. J., Pertile, M. D., & Moore, H. M. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-3015 · Cited by 140

Detection of Somatic Structural Variants Enables Quantification and Characterization of Circulating Tumor DNA in Children With Solid Tumors

Klega, K. S., Imamović, A., Ha, G., Clapp, A. N., Meyer, S. C., Ward, A., Clinton, C., Nag, A., Allen, E. M. V., Mullen, E. A., et al. (2018) · JCO Precision Oncology · doi:10.1200/po.17.00285 · Cited by 139

Epigenetic Biomarkers in Cell-Free DNA and Applications in Liquid Biopsy

Gai, W., & Sun, K. (2019) · Genes · doi:10.3390/genes10010032 · Cited by 138

Circulating muscle-specific microRNA, miR-206, as a potential diagnostic marker for rhabdomyosarcoma

Miyachi, M., Tsuchiya, K., Yoshida, H., Yagyu, S., Kikuchi, K., Misawa, A., Iehara, T., & Hosoi, H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.08.015 · Cited by 133

Detection of circulating tumor cells in patients with Ewing's sarcoma and peripheral primitive neuroectodermal tumor.

West, D. C., Grier, H. E., Swallow, M. M., Demetri, G. D., Granowetter, L., & Sklar, J. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.2.583 · Cited by 132

Urine as a Source of Liquid Biopsy for Cancer

Oshi, M., Murthy, V., Takahashi, H., Huyser, M. R., Okano, M., Tokumaru, Y., Rashid, O. M., Matsuyama, R., Endo, I., & Takabe, K. (2021) · Cancers · doi:10.3390/cancers13112652 · Cited by 131

Shallow Whole Genome Sequencing on Circulating Cell-Free DNA Allows Reliable Noninvasive Copy-Number Profiling in Neuroblastoma Patients

Roy, N. V., Linden, M. V. D., Menten, B., Dheedene, A., Vandeputte, C., Dorpe, J. V., Laureys, G., Renard, M., Sante, T., Lammens, T., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0675 · Cited by 128

Proteomic approaches for serum biomarker discovery in cancer.

Maurya, P., Meleady, P., Dowling, P., & CLYNES, M. M. (2007) · PubMed · Cited by 123

Neuroblastoma mRNAs Predict Outcome in Children With Stage 4 Neuroblastoma: A European HR-NBL1/SIOPEN Study

Viprey, V. F., Gregory, W. M., Corrias, M. V., Tchirkov, A., Swerts, K., Vícha, A., Dallorso, S., Brock, P. R., Luksch, R., Valteau‐Couanet, D., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.53.3604 · Cited by 121

Non-blood circulating tumor DNA detection in cancer

Peng, M., Chen, C., Hulbert, A., Brock, M. V., & Yu, F. (2017) · Oncotarget · doi:10.18632/oncotarget.19942 · Cited by 119

Upregulation of long non-coding RNA TUG1 correlates with poor prognosis and disease status in osteosarcoma

Ma, B., Li, M., Zhang, L., Huang, M., Lei, J.-B., Fu, G.-H., Liu, C.-X., Lai, Q.-W., Chen, Q., & Wang, Y.-L. (2015) · Tumor Biology · doi:10.1007/s13277-015-4301-6 · Cited by 118

Clinical significance of circulating miR-25-3p as a novel diagnostic and prognostic biomarker in osteosarcoma

Fujiwara, T., Uotani, K., Yoshida, A., Morita, T., Nezu, Y., Kobayashi, E., Yoshida, A., Uehara, T., Omori, T., Sugiu, K., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16498 · Cited by 118

Integrated microfluidic-SERS for exosome biomarker profiling and osteosarcoma diagnosis

Han, Z., Peng, X., Yang, Y., Yi, J., Zhao, D., Bao, Q., Long, S., Yu, S., Xu, X., Liu, B., et al. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114709 · Cited by 118

Germline and somatic NF1 mutations in sporadic and NF1‐associated malignant peripheral nerve sheath tumours

Bottillo, I., Ahlquist, T. C., Brekke, H. R., Danielsen, S. A., van den Berg, E., Mertens, F., Lothe, R. A., & Dallapiccola, B. (2008) · The Journal of Pathology · doi:10.1002/path.2494 · Cited by 118

Application of miRNAs in the diagnosis and monitoring of testicular germ cell tumours

Almstrup, K., Lobo, J., Mørup, N., Belge, G., Meyts, E. R., Looijenga, L. H. J., & Dieckmann, K. (2020) · Nature Reviews Urology · doi:10.1038/s41585-020-0296-x · Cited by 115

Longitudinal tracking of 97 esophageal adenocarcinomas using liquid biopsy sampling

Ococks, E., Frankell, A. M., Masqué‐Soler, N., Grehan, N., Northrop, A., Coles, H., Redmond, A. M., Devonshire, G., Weaver, J. M. J., Hughes, C. D., et al. (2021) · Annals of Oncology · doi:10.1016/j.annonc.2020.12.010 · Cited by 114

Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma

Lin, P. P., Wang, Y., & Lozano, G. (2010) · Sarcoma · doi:10.1155/2011/276463 · Cited by 114

A three-plasma miRNA signature serves as novel biomarkers for osteosarcoma

Ouyang, L., Liu, P., Yang, S., Ye, S., Xu, W., & Liu, X. (2012) · Medical Oncology · doi:10.1007/s12032-012-0340-7 · Cited by 113

Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Chicard, M., Boyault, S., Daage, L. C., Richer, W., Gentien, D., Pierron, G., Lapouble, E., Bellini, A., Clément, N., Iacono, I., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0500 · Cited by 113

Circulating Neuroblastoma Cells Detected by Reverse Transcriptase Polymerase Chain Reaction for Tyrosine Hydroxylase mRNA Are an Independent Poor Prognostic Indicator in Stage 4 Neuroblastoma in Children Over 1 Year

Burchill, S. A., Lewis, I. J., Abrams, K. R., Riley, R. D., Imeson, J., Pearson, A. D. J., Pinkerton, C., & Selby, P. J. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.6.1795 · Cited by 113

Circulating MicroRNAs, the Next-Generation Serum Biomarkers in Testicular Germ Cell Tumours: A Systematic Review

Leao, R. R. N., Albersen, M., Looijenga, L. H. J., Tandstad, T., Kollmannsberger, C., Murray, M. J., Culine, S., Coleman, N., Belge, G., Hamilton, R. J., et al. (2021) · European Urology · doi:10.1016/j.eururo.2021.06.006 · Cited by 113

Serum Levels of MicroRNAs miR-371-3: A Novel Class of Serum Biomarkers for Testicular Germ Cell Tumors?

Belge, G., Dieckmann, K., Spiekermann, M., Balks, T., & Bullerdiek, J. (2012) · European Urology · doi:10.1016/j.eururo.2012.02.037 · Cited by 112

In Brief: Classifications in Brief

Jawad, M. U., & Scully, S. P. (2010) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-010-1315-7 · Cited by 111

Clinical significance of clonal hematopoiesis in the interpretation of blood liquid biopsy

Chan, H. T., Nagayama, S., Chin, Y. M., Otaki, M., Hayashi, R., Kiyotani, K., Fukunaga, Y., Ueno, M., Nakamura, Y., & Low, S. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12727 · Cited by 110

Metastatic Progression of Osteosarcomas: A Review of Current Knowledge of Environmental versus Oncogenic Drivers

Odri, G. A., Tchicaya-Bouanga, J., Yoon, D. J. Y., & Modrowski, D. (2022) · Cancers · doi:10.3390/cancers14020360 · Cited by 108

GD2‐targeted immunotherapy and potential value of circulating microRNAs in neuroblastoma

Gholamin, S., Mirzaei, H., Razavi, S., Hassanian, S. M., Saadatpour, L., Masoudifar, A., Shahidsales, S., & Avan, A. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25793 · Cited by 108

Presence of tumor cells in bone marrow but not in blood is associated with adverse prognosis in patients with Ewing's tumor. Société Française d'Oncologie Pédiatrique.

Fagnou, C., Michon, J. M., Peter, M., Bernoux, A., Oberlin, O., Zucker, J. M., Magdelénat, H., & Delattre, O. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.5.1707 · Cited by 108

Neuroblastoma cell detection by reverse transcriptase‐polymerase chain reaction (RT‐PCR) for tyrosine hydroxylase mRNA

Burchill, S. A., Bradbury, F. M., Smith, B., Lewis, I. J., & Selby, P. J. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910570510 · Cited by 106

Identification and Validation Model for Informative Liquid Biopsy-Based microRNA Biomarkers: Insights from Germ Cell Tumor In Vitro, In Vivo and Patient-Derived Data

Lobo, J., Gillis, A., van den Berg, A., Dorssers, L. C. J., Belge, G., Dieckmann, K., Roest, H. P., van der Laan, L. J. W., Gietema, J. A., Hamilton, R. J., et al. (2019) · Cells · doi:10.3390/cells8121637 · Cited by 105

Pediatric Liver Tumors

Ng, K., & Mogul, D. B. (2018) · Clinics in Liver Disease · doi:10.1016/j.cld.2018.06.008 · Cited by 103

Genomic EWSR1 Fusion Sequence as Highly Sensitive and Dynamic Plasma Tumor Marker in Ewing Sarcoma

Krumbholz, M., Hellberg, J., Steif, B., Bäuerle, T., Gillmann, C., Fritscher, T., Agaimy, A., Frey, B., Juengert, J., Wardelmann, E., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-3028 · Cited by 100

Exosomal miR-675 from metastatic osteosarcoma promotes cell migration and invasion by targeting CALN1

Gong, L., Bao, Q., Hu, C., Wang, J., Zhou, Q. G., Li, W., Tong, L., Zhang, W., & Shen, Y. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.04.016 · Cited by 100

MicroRNAs in osteosarcoma

Zhang, J., Yan, Y., Wang, C., Zhang, S., Yu, X., & Wang, W. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.01.025 · Cited by 100

Detection of neuroblastoma cells in blood.

Moss, T. J., & Sanders, D. G. (1990) · Journal of Clinical Oncology · doi:10.1200/jco.1990.8.4.736 · Cited by 99

European Union Ethical Considerations for Clinical Trials on Medicinal Products Conducted with the Paediatric Population

(2008) · European Journal of Health Law · doi:10.1163/157180908x333228 · Cited by 99

Gain of 1q is associated with inferior event‐free and overall survival in patients with favorable histology Wilms tumor: A report from the Children's Oncology Group

Gratias, E. J., Jennings, L. J., Anderson, J. R., Dome, J. S., Grundy, P. E., & Perlman, E. J. (2013) · Cancer · doi:10.1002/cncr.28239 · Cited by 97

Identification of a Plasma Four-microRNA Panel as Potential Noninvasive Biomarker for Osteosarcoma

Lian, F., Cui, Y., Zhou, C., Gao, K., & Wu, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121499 · Cited by 94

miR-491 Inhibits Osteosarcoma Lung Metastasis and Chemoresistance by Targeting αB-crystallin

Wang, S., Luo, S., Liu, C., Piao, Z.-H., Gou, W., Wang, Y., Guan, W., Li, Q., Zou, H., Yang, Z., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.05.018 · Cited by 94

Pediatric Germ Cell Tumors: A Developmental Perspective

Pierce, J. L., Frazier, A. L., & Amatruda, J. F. (2018) · Advances in Urology · doi:10.1155/2018/9059382 · Cited by 93

Prediction of MYCN Amplification in Neuroblastoma Using Serum DNA and Real-Time Quantitative Polymerase Chain Reaction

Gotoh, T., Hosoi, H., Iehara, T., Kuwahara, Y., Osone, S., Tsuchiya, K., Ohira, M., Nakagawara, A., Kuroda, H., & Sugimoto, T. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.014 · Cited by 93

Liquid biopsy at the frontier in renal cell carcinoma: recent analysis of techniques and clinical application

Li, M., Li, L., Zheng, J., Li, Z., Li, S., Wang, K., & Chen, X. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01745-7 · Cited by 89

Fusion status in patients with lymph node‐positive (N1) alveolar rhabdomyosarcoma is a powerful predictor of prognosis: Experience of the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG)

Gallego, S., Zanetti, I., Orbach, D. H., Ranchère‐Vince, D., SHIPLEY, J. M., Zin, A., Bergeron, C., Salvo, G. L. D., Chisholm, J., Ferrari, A., et al. (2018) · Cancer · doi:10.1002/cncr.31553 · Cited by 88

Osteosarcoma, chondrosarcoma and Ewing sarcoma: clinical aspects, biomarker discovery and liquid biopsy

Aran, V., Devalle, S., Meohas, W., Heringer, M., Cunha Caruso, A., Pinheiro Aguiar, D., Leite Duarte, M. E., & Moura Neto, V. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103340 · Cited by 87

Using droplet digital PCR to analyzeMYCNandALKcopy number in plasma from patients with neuroblastoma

Lodrini, M., Sprüssel, A., Astrahantseff, K., Tiburtius, D., Konschak, R., Lode, H. N., Fischer, M., Keilholz, U., Eggert, A., & Deubzer, H. E. (2017) · Oncotarget · doi:10.18632/oncotarget.19076 · Cited by 87

Exosomes containing differential expression of microRNA and mRNA in osteosarcoma that can predict response to chemotherapy

Xu, J., Wang, Y., Zhang, S., Chen, Y., Gu, H.-F., Dou, X., Xia, B., Bi, Q., & Fan, S.-W. (2017) · Oncotarget · doi:10.18632/oncotarget.18373 · Cited by 86

From genomics to metabolomics: emerging metastatic biomarkers in osteosarcoma

Dean, D. C., Shen, S., Hornicek, F. J., & Duan, Z. (2018) · Cancer and Metastasis Reviews · doi:10.1007/s10555-018-9763-8 · Cited by 86

Circulating MYCN DNA as a tumor-specific marker in neuroblastoma patients.

Combaret, V., Audoynaud, C., Iacono, I., Favrot, M., Schell, M., Bergeron, C., & Puisieux, A. (2002) · PubMed · Cited by 86

Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study

Szymanski, J. J., Sundby, R. T., Jones, P. A., Srihari, D., Earland, N. J., Harris, P. K. W., Feng, W., Qaium, F., Lei, H., Roberts, D., et al. (2021) · PLoS Medicine · doi:10.1371/journal.pmed.1003734 · Cited by 86

Serum miR-195 is a diagnostic and prognostic marker for osteosarcoma

Cai, H., Zhao, H., Tang, J., & Wu, H. (2014) · Journal of Surgical Research · doi:10.1016/j.jss.2014.11.025 · Cited by 84

Wilms tumor

Pater, L. E., Melchior, P., Rübe, C., Cooper, B. T., McAleer, M. F., Kalapurakal, J. A., & Paulino, A. C. (2020) · Pediatric Blood & Cancer · doi:10.1002/pbc.28257 · Cited by 84

Recent Advances and Challenges in the Treatment of Rhabdomyosarcoma

Miwa, S., Yamamoto, N., Hayashi, K., Takeuchi, A., Igarashi, K., & Tsuchiya, H. (2020) · Cancers · doi:10.3390/cancers12071758 · Cited by 82

Cross‐species identification of a plasma microRNA signature for detection, therapeutic monitoring, and prognosis in osteosarcoma

Allen‐Rhoades, W. A., Kurenbekova, L., Satterfield, L., Parikh, N., Fuja, D. G., Shuck, R. L., Rainusso, N. C., Trucco, M. M., Barkauskas, D. A., Jo, E., et al. (2015) · Cancer Medicine · doi:10.1002/cam4.438 · Cited by 81

Circulating miRNAs as Diagnostic and Prognostic Biomarkers in Common Solid Tumors: Focus on Lung, Breast, Prostate Cancers, and Osteosarcoma

Bottani, M., Banfi, G., & Lombardi, G. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101661 · Cited by 81

Beyond the Blood: CSF-Derived cfDNA for Diagnosis and Characterization of CNS Tumors

McEwen, A. E., Leary, S. E. S., & Lockwood, C. M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00045 · Cited by 81

Identification of Serum MicroRNA-21 as a Biomarker for Chemosensitivity and Prognosis in Human Osteosarcoma

Yuan, J., Chen, L., Chen, X., Sun, W., & Zhou, X. H. (2012) · Journal of International Medical Research · doi:10.1177/030006051204000606 · Cited by 80

Molecular testing of rhabdomyosarcoma in clinical trials to improve risk stratification and outcome: A consensus view from European paediatric Soft tissue sarcoma Study Group, Children's Oncology Group and Cooperative Weichteilsarkom-Studiengruppe

Hettmer, S., Linardic, C. M., Kelsey, A. M., Rudzinski, E. R., Vokuhl, C., Selfe, J., Ruhen, O., Shern, J. F., Khan, J. I., Kovach, A. R., et al. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2022.05.036 · Cited by 80

Detecting Minimal Residual Disease in Neuroblastoma: The Superiority of a Panel of Real-Time Quantitative PCR Markers

Stutterheim, J., Gerritsen, A., Zappeij‐Kannegieter, L., Yalçın, B., Dee, R., van Noesel, M. M., Berthold, F., Versteeg, R., Caron, H. N., van der Schoot, C. E., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.117945 · Cited by 80

Antiphospholipid syndrome associated with immunotherapy for patients with melanoma

Naldi, L., Locati, F., Finazzi, G., Barbui, T., Cainelli, T., Becker, R. C. J., & Bröcker, E.-B. (1995) · Cancer · doi:10.1002/1097-0142(19950601)75:11 · Cited by 80

Prognostic Factors for Wilms Tumor Recurrence: A Review of the Literature

Groenendijk, A., Spreafico, F., de Krijger, R. R., Drost, J., Brok, J. S., Perotti, D., van Tinteren, H., Venkatramani, R., Godzinski, J. K., Rübe, C., et al. (2021) · Cancers · doi:10.3390/cancers13133142 · Cited by 80

Pediatric Non-Rhabdomyosarcoma Soft Tissue Sarcomas: Standard of Care and Treatment Recommendations from the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG)

Ferrari, A., Brennan, B. M. D., Casanova, M., Corradini, N., Berlanga, P., Schoot, R. A., Ramirez, G. L., Safwat, A., Guillén, G., Dall’Igna, P., et al. (2022) · Cancer Management and Research · doi:10.2147/cmar.s368381 · Cited by 80

MiR-326 is a diagnostic biomarker and regulates cell survival and apoptosis by targeting Bcl-2 in osteosarcoma

Cao, L., Wang, J., & Wang, Q. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.10.008 · Cited by 79

Detection of tumor ALK status in neuroblastoma patients using peripheral blood

Combaret, V., Iacono, I., Bellini, A., Bréjon, S., Bernard, V., Marabelle, A., Coze, C., Pierron, G., Lapouble, E., Schleiermacher, G., et al. (2015) · Cancer Medicine · doi:10.1002/cam4.414 · Cited by 79

Clonogenicity of circulating neuroblastoma cells: implications regarding peripheral blood stem cell transplantation

Moss, T., Cairo, M. S., Santana, V., Weinthal, J., Hurvitz, C. G., & Bostrom, B. (1994) · Blood · doi:10.1182/blood.v83.10.3085.3085 · Cited by 79

Quantitation of marrow disease in neuroblastoma by real-time reverse transcription-PCR.

Cheung, I. Y., & Cheung, N. V. (2001) · PubMed · Cited by 78

Exosomal MiRNAs in Pediatric Cancers

Galardi, A., Colletti, M., Paolo, V. D., Vitullo, P., Antonetti, L., Russo, I., & Giannatale, A. D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184600 · Cited by 77

Exploiting Gene Expression Profiling to Identify Novel Minimal Residual Disease Markers of Neuroblastoma

Cheung, I. Y., Feng, Y., Gerald, W. L., & Cheung, N. V. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0541 · Cited by 77

miRNA-223 is a potential diagnostic and prognostic marker for osteosarcoma

Dong, J., Liu, Y., Liao, W., Liu, R., Shi, P., & Wang, L. (2016) · Journal of bone oncology · doi:10.1016/j.jbo.2016.05.001 · Cited by 77

Highly personalized detection of minimal Ewing sarcoma disease burden from plasma tumor DNA

Hayashi, M., Chu, D. T. W., Meyer, C. F., Llosa, N. J., McCarty, G., Morris, C. D., Levin, A. S., Wolinsky, J., Albert, C. M., Steppan, D. A., et al. (2016) · Cancer · doi:10.1002/cncr.30144 · Cited by 76

Serum MicroRNA-371a-3p Levels Predict Viable Germ Cell Tumor in Chemotherapy-naïve Patients Undergoing Retroperitoneal Lymph Node Dissection

Lafin, J. T., Singla, N., Woldu, S. L., Lotan, Y., Lewis, C. M., Majmudar, K., Savelyeva, A., Kapur, P., Margulis, V., Strand, D. W., et al. (2019) · European Urology · doi:10.1016/j.eururo.2019.10.005 · Cited by 76

A new generation of biomarkers for malignant germ cell tumours

Murray, M. J., & Coleman, N. (2012) · Nature Reviews Urology · doi:10.1038/nrurol.2012.86 · Cited by 75

Circulating miR-148a is a significant diagnostic and prognostic biomarker for patients with osteosarcoma

Ma, W., Zhang, X., Chai, J., Chen, P., Ren, P., & Gong, M. (2014) · Tumor Biology · doi:10.1007/s13277-014-2565-x · Cited by 74

Current treatment for Wilms tumor: COG and SIOP standards

Wang, J., Li, M.-J., Tang, D., Gu, W., Mao, J., & Shu, Q. (2019) · World Journal of Pediatric Surgery · doi:10.1136/wjps-2019-000038 · Cited by 73

Liquid biopsy: from concept to clinical application

Alix‐Panabières, C., Marchetti, D., & Lang, J. E. (2023) · Scientific Reports · doi:10.1038/s41598-023-48501-x · Cited by 73

Circulating tumour cells in the -omics era: how far are we from achieving the ‘singularity’?

Visal, T. H., den Hollander, P., Cristofanilli, M., & Mani, S. A. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01768-9 · Cited by 72

Serum levels of microRNA-133b and microRNA-206 expression predict prognosis in patients with osteosarcoma.

Zhang, C., Yao, C., Li, H., Wang, G., & He, X. (2014) · PubMed Central · Cited by 72

Assessment of circulating tumor DNA in pediatric solid tumors: The promise of liquid biopsies

Abbou, S. D., Shulman, D. S., DuBois, S. G., & Crompton, B. D. (2019) · Pediatric Blood & Cancer · doi:10.1002/pbc.27595 · Cited by 72

A causal role for circulating miR-34b in osteosarcoma

Tian, Q., Jia, J., Ling, S., Liu, Y., Yang, S., & Shao, Z. (2013) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2013.08.024 · Cited by 71

Solid Tumors of Childhood Display Specific Serum microRNA Profiles

Murray, M. J., Raby, K. L., Saini, H. K., Bailey, S., Wool, S. V., Tunnacliffe, J. M., Enright, A. J., Nicholson, J. C., & Coleman, N. (2014) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-14-0669 · Cited by 70

Use of Reverse Transcriptase Polymerase Chain Reaction for Diagnosis and Staging of Alveolar Rhabdomyosarcoma, Ewing Sarcoma Family of Tumors, and Desmoplastic Small Round Cell Tumor

Athale, U. H., Shurtleff, S. A., Jenkins, J. J., Poquette, C. A., Tan, M. T., Downing, J. R., & Pappo, A. S. (2001) · The American journal of pediatric hematology/oncology · doi:10.1097/00043426-200102000-00006 · Cited by 70

Molecular detection of GAGE expression in peripheral blood and bone marrow: utility as a tumor marker for neuroblastoma.

Cheung, I. Y., & Cheung, N. V. (1997) · PubMed · Cited by 70

Combined Elevation of microRNA-196a and microRNA-196b in Sera Predicts Unfavorable Prognosis in Patients with Osteosarcomas

Zhang, C., Yao, C., Li, H., Wang, G., & He, X. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15046544 · Cited by 69

Integrated Expression of Circulating miR375 and miR371 to Identify Teratoma and Active Germ Cell Malignancy Components in Malignant Germ Cell Tumors

Nappi, L., Thi, M., Adra, N., Hamilton, R. J., Leao, R. R. N., Lavoie, J., Soleimani, M., Eigl, B. J., Chi, K., Gleave, M. E., et al. (2020) · European Urology · doi:10.1016/j.eururo.2020.10.024 · Cited by 69

The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children: a review

Paemel, R. V., Vlug, R., Preter, K. D., Roy, N. V., Speleman, F., Willems, L., Lammens, T., Laureys, G., Schleiermacher, G., Tytgat, G. A. M., et al. (2020) · European Journal of Pediatrics · doi:10.1007/s00431-019-03545-y · Cited by 68

Preoperative platelet-lymphocyte ratio is superior to neutrophil-lymphocyte ratio as a prognostic factor for soft-tissue sarcoma

Que, Y., Qiu, H., Li, Y., Chen, Y., Xiao, W., Zhou, Z., & Zhang, X. (2015) · BMC Cancer · doi:10.1186/s12885-015-1654-6 · Cited by 67

Managing side effects of childhood cancer treatment

Bryant, R. (2003) · Journal of Pediatric Nursing · doi:10.1053/jpdn.2003.11 · Cited by 66

Size-based detection of sarcoma circulating tumor cells and cell clusters

Hayashi, M., Zhu, P., McCarty, G., Meyer, C. F., Pratilas, C. A., Levin, A. S., Morris, C. D., Albert, C. M., Jackson, K. W., Tang, C., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.20697 · Cited by 66

MicroRNA-Based Diagnosis and Treatment of Metastatic Human Osteosarcoma

Sasaki, R., Osaki, M., & Okada, F. (2019) · Cancers · doi:10.3390/cancers11040553 · Cited by 65

Minimally invasive classification of paediatric solid tumours using reduced representation bisulphite sequencing of cell-free DNA: a proof-of-principle study

Paemel, R. V., Koker, A. D., Vandeputte, C., van Zogchel, L. M. J., Lammens, T., Laureys, G., Vandesompele, J., Schleiermacher, G., Chicard, M., Roy, N. V., et al. (2020) · Epigenetics · doi:10.1080/15592294.2020.1790950 · Cited by 65

Standardisation of operating procedures for the detection of minimal disease by QRT-PCR in children with neuroblastoma: Quality assurance on behalf of SIOPEN-R-NET

Viprey, V. F., Corrias, M. V., Kågedal, B., Oltra, S., Swerts, K., Vícha, A., Ladenstein, R. L., & Burchill, S. A. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.08.007 · Cited by 64

Non-coding RNAs as biomarkers in liquid biopsies with a special emphasis on extracellular vesicles in urological malignancies

Zeuschner, P., Linxweiler, J., & Junker, K. (2019) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2019.1665998 · Cited by 63

Childhood Rhabdomyosarcoma

Wang, C. (2011) · Journal of Dental Research · doi:10.1177/0022034511421490 · Cited by 63

Detection of circulating tumor DNA in patients with osteosarcoma

Barris, D. M., Weiner, S. B., Dubin, R. A., Fremed, M., Zhang, X., Piperdi, S., Zhang, W., Maqbool, S., Gill, J., Roth, M., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24268 · Cited by 63

Long noncoding RNA ATB promotes osteosarcoma cell proliferation, migration and invasion by suppressing miR-200s.

Han, F., Wang, C., Wang, Y., & Zhang, L. (2017) · PubMed Central · Cited by 63

Circulating MicroRNA-92b-3p as a Novel Biomarker for Monitoring of Synovial Sarcoma

Uotani, K., Fujiwara, T., Yoshida, A., Iwata, S., Morita, T., Kiyono, M., Yokoo, S., Kunisada, T., Takeda, K., Hasei, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12660-5 · Cited by 62

Circulating serum miRNAs as potential biomarkers for nephroblastoma

Ludwig, N., Nourkami‐Tutdibi, N., Backes, C., Lenhof, H., Graf, N. M., Keller, A., & Meese, E. U. (2015) · Pediatric Blood & Cancer · doi:10.1002/pbc.25481 · Cited by 62

Ewing Family Tumors

de Álava, E., Lozano, M. D., Patiño‐García, A., Sierrasesúmaga, L., & Pardo-Mindán, F. J. (1998) · Diagnostic Molecular Pathology · doi:10.1097/00019606-199806000-00005 · Cited by 62

miR-421 is a diagnostic and prognostic marker in patients with osteosarcoma

Zhou, S., Wang, B., Hu, J. X., Zhou, Y., Jiang, M., Wu, M., Qin, L., & Yang, X. (2016) · Tumor Biology · doi:10.1007/s13277-015-4578-5 · Cited by 62

Expression of Five Neuroblastoma Genes in Bone Marrow or Blood of Patients with Relapsed/Refractory Neuroblastoma Provides a New Biomarker for Disease and Prognosis

Marachelian, A., Villablanca, J. G., Liu, C. W., Liu, B., Goodarzian, F., Lai, H., Shimada, H., Tran, H. C., Parra, J. A., Gallego, R., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2647 · Cited by 62

Progress toward liquid biopsies in pediatric solid tumors

Weiser, D. A., West-Szymanski, D. C., Fraint, E., Weiner, S., Rivas, M. A., Zhao, C. W. T., He, C., & Applebaum, M. A. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09825-1 · Cited by 61

The lnc RNA HNF 1A‐ AS 1 is a negative prognostic factor and promotes tumorigenesis in osteosarcoma

Cai, L., Lv, J., Zhang, Y., Li, J., Wang, Y., & Yang, H. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12944 · Cited by 60

Detection of microscopic neuroblastoma in marrow by histology, immunocytology, and reverse transcription-PCR of multiple molecular markers.

Cheung, I. Y., Barber, D., & Cheung, N. K. (1998) · PubMed · Cited by 60

Paediatric non-rhabdomyosarcoma soft tissue sarcomas: the prospective NRSTS 2005 study by the European Pediatric Soft Tissue Sarcoma Study Group (EpSSG)

Ferrari, A., van Noesel, M. M., Brennan, B. M. D., Zanetti, I., Corradini, N., Casanova, M., Berlanga, P., Merks, J. H. M., Alaggio, R., Schifflers, S., et al. (2021) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(21)00159-0 · Cited by 60

Imaging in childhood cancer: A society for pediatric radiology and children's oncology group joint task force report

Weiser, D. A., Kaste, S. C., Siegel, M. J., & Adamson, P. C. (2013) · Pediatric Blood & Cancer · doi:10.1002/pbc.24533 · Cited by 59

Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors

Park, S., Sawitzki, B., Kluwe, L., Mautner, V. F., Holtkamp, N., & Kurtz, A. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-109 · Cited by 59

Relevance of microRNAs in normal and malignant development, including human testicular germ cell tumours

Looijenga, L. H. J., Gillis, A., Stoop, H., Hersmus, R., & Oosterhuis, J. W. (2007) · International Journal of Andrology · doi:10.1111/j.1365-2605.2007.00765.x · Cited by 59

Correlation of elevated level of blood midkine with poor prognostic factors of human neuroblastomas

Ikematsu, S., Nakagawara, A., Nakamura, Y., Sakuma, S., Wakai, K., Muramatsu, T., & Kadomatsu, K. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600938 · Cited by 59

Renal Tumors of Childhood—A Histopathologic Pattern-Based Diagnostic Approach

Ooms, A. H. A. G., Vujanic, G. M., D’Hooghe, E., Collini, P., L’Herminé, A. C., Vokuhl, C., Graf, N. M., van den Heuvel‐Eibrink, M. M., & de Krijger, R. R. (2020) · Cancers · doi:10.3390/cancers12030729 · Cited by 59

Diagnostic and prognostic potentials of microRNA-27a in osteosarcoma

Tang, J., Zhao, H., Cai, H., & Wu, H. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.01.025 · Cited by 58

The prognostic value of fast molecular response of marrow disease in patients aged over 1year with stage 4 neuroblastoma

Stutterheim, J., Zappeij‐Kannegieter, L., Versteeg, R., Caron, H. N., van der Schoot, C. E., & Tytgat, G. A. M. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.02.003 · Cited by 58

Usefulness and real-world outcomes of next generation sequencing testing in patients with cancer: an observational study on the impact of selection based on clinical judgement

Colomer, R., Miranda, J., Romero-Laorden, N., Hornedo, J., González‐Cortijo, L., Mouron, S. A., Bueno, M. J., Mondéjar, R., & Quintela-Fandiño, M. (2023) · EClinicalMedicine · doi:10.1016/j.eclinm.2023.102029 · Cited by 57

Dynamics of Minimal Residual Disease in Neuroblastoma Patients

Uemura, S., Ishida, T., Thwin, K. K. M., Yamamoto, N., Tamura, A., Kishimoto, K., Hasegawa, D., Kosaka, Y., Nino, N., Lin, K. S., et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00455 · Cited by 57

Serum Small RNA Sequencing and miR-375 Assay Do Not Identify the Presence of Pure Teratoma at Postchemotherapy Retroperitoneal Lymph Node Dissection

Lafin, J. T., Kenigsberg, A. P., Meng, X., Abe, D., Savelyeva, A., Singla, N., Woldu, S. L., Lotan, Y., Mauck, R. J., Lewis, C. M., et al. (2021) · European Urology Open Science · doi:10.1016/j.euros.2021.02.003 · Cited by 57

Circulating biomarkers in osteosarcoma: new translational tools for diagnosis and treatment

Raimondi, L., Luca, A. D., Costa, V., Amodio, N., Carina, V., Bellavia, D., Tassone, P., Pagani, S., Fini, M., Alessandro, R., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19852 · Cited by 56

Diagnostic and prognostic values of serum exosomal microRNA-21 in children with hepatoblastoma: a Chinese population-based study

Liu, W., Chen, S., & Liu, B. (2016) · Pediatric Surgery International · doi:10.1007/s00383-016-3960-8 · Cited by 56

Quantitation of GD2 Synthase mRNA by Real-Time Reverse Transcriptase Polymerase Chain Reaction: Clinical Utility in Evaluating Adjuvant Therapy in Neuroblastoma

Cheung, I. Y., Piccolo, M. S. L., Kushner, B. H., Kramer, K., & Cheung, N. V. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.02.055 · Cited by 56

Exosomal microRNAs from Longitudinal Liquid Biopsies for the Prediction of Response to Induction Chemotherapy in High-Risk Neuroblastoma Patients: A Proof of Concept SIOPEN Study ‖

Morini, M., Cangelosi, D., Segalerba, D., Marimpietri, D., Raggi, F., Castellano, A., Fruci, D., de Mora, J. F., Cañete, A., Yáñez, Y., et al. (2019) · Cancers · doi:10.3390/cancers11101476 · Cited by 56

Bax immunohistochemical expression in breast carcinoma: A study with long term follow-up

Veronese, S. M., Mauri, F. A., Caffo, O., Scaioli, M., Aldovini, D., Perrone, G., Galligioni, E., Doglioni, C., Palma, P., & Barbareschi, M. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980220)79:1 · Cited by 55

Quantitative Analysis of Tyrosine Hydroxylase mRNA for Sensitive Detection of Neuroblastoma Cells in Blood and Bone Marrow

Träger, C., Kogner, P., Lindskog, M., Ponthan, F., Kullman, A., & Kågedal, B. (2003) · Clinical Chemistry · doi:10.1373/49.1.104 · Cited by 55

Quantum biophysics of water

Stekhin, A., Yakovleva, G., Pronko, K., & Zemskov, V. (2018) · Clinical Practice · doi:10.4172/clinical-practice.1000393 · Cited by 55

Combined low-pass whole genome and targeted sequencing in liquid biopsies for pediatric solid tumors

Christodoulou, E., Yellapantula, V., O’Halloran, K., Xu, L., Berry, J. L., Cotter, J. A., Zdanowicz, A., Mascarenhas, L., Amatruda, J. F., Ostrow, D., et al. (2023) · npj Precision Oncology · doi:10.1038/s41698-023-00357-0 · Cited by 55

Exosomal hsa-miR199a-3p Promotes Proliferation and Migration in Neuroblastoma

Ma, J., Xu, M., Yin, M., Hong, J., Chen, H., Gao, Y., Xie, C., Shen, N., Gu, S., & Mo, X. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00459 · Cited by 54

Amino acid metabolism in breast cancer: pathogenic drivers and therapeutic opportunities

Liu, Y., Zong, X., Altea‐Manzano, P., & Fu, J. (2025) · Protein & Cell · doi:10.1093/procel/pwaf011 · Cited by 32

GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing

Huang, A., Guo, D., Su, Z., Zhong, Y., Liu, L., Xiong, Z., He, D.-L., Yan, B., Li, Q., Feng, Z., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02367-x · Cited by 23

Microfluidics-based label-free SERS profiling of exosomes with machine learning for osteosarcoma diagnosis

Jin, Y., Zhang, J., Wu, X., Qu, C., Fang, X., Yang, Y., Yuan, Y., Liu, H., & Han, Z. (2025) · Talanta · doi:10.1016/j.talanta.2025.128276 · Cited by 15

Sensitive detection of minimal residual disease and immunotherapy targets by multi-modal bone marrow analysis in high-risk neuroblastoma – a multi-center study

Gelineau, N. U., Bozsaky, E., van Zogchel, L. M. J., Rifatbegovic, F., Lazic, D., Ziegler, A. M., Javadi, A., Zappeij‐Kannegieter, L., Pötschger, U., Fiocco, M. F., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03481-w · Cited by 7

Extracellular vesicle biomarkers: current status and future perspectives as novel tools in liquid biopsy

Huang, W., Zhao, M., Li, L., Chen, Q., Yang, M., Zhou, C., Qi, M., Wang, Y., Luo, L., Liang, W., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1853671 · Cited by 5

Evaluating Circulating Biomarkers for Diagnosis, Prognosis, and Tumor Monitoring in Pediatric Sarcomas: Recent Advances and Future Directions

Maqueda, J. J., De Feo, A., & Scotlandi, K. (2024) · Biomolecules · doi:10.3390/biom14101306 · Cited by 4

Breast cancer frontiers: mapping molecular signals, intelligent diagnostics, and adaptive therapies

Kumar, D., Choudhary, N., Kaur, S., & Kondaveeti, S. B. (2026) · Discover Oncology · doi:10.1007/s12672-026-04453-y · Cited by 4

Glucose metabolism in glioma: an emerging sight with ncRNAs

Rong, J., Wang, Q., Li, T., Qian, J., & Cheng, J. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03499-8 · Cited by 3

Circulating Tumor DNA and microRNA–Based Liquid Biopsy for Longitudinal Treatment Monitoring and Recurrence Prediction in Pediatric Sarcomas: A Prospective Cohort Study

Kurdi, M., Hassan, A., Reda, B., Nooh, A., Alsobaie, M., Alkhotani, A., Mirdad, D. S., Almansouri, M., Khashoggi, K., Halwani, M., et al. (2026) · Oncology Research · doi:10.32604/or.2026.078833 · Cited by 2

Exploring a Circulating miRNA Signature for PMM2 ‐ CDG : Initial Insights Toward Diagnosis, Stratification, and Monitoring

Epifani, F., Cabús, L., Nolasco, G. A., Bolasell, M., Pérez‐Boza, J., Alcalá, A. M., Fernández, P., Lizano, E., Márquez, G., Belmonte, S., et al. (2025) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.70104 · Cited by 2

Identification and validation of liquid biopsy-based methylation biomarkers for germ cell tumor subtypes

Janssen, F. W., Gillis, A. J. M., Gouswaart, P. B., Kester, L. A., Takami, H., Ichimura, K., Eleveld, T. F., & Looijenga, L. H. J. (2026) · Communications Medicine · doi:10.1038/s43856-026-01587-6 · Cited by 2

Extracellular Vesicles in the Biology and Liquid Biopsy Diagnostics of Pediatric High‐Grade Glioma – Emerging Findings and Opportunities

Jahouri, S., Montermini, L., Tawil, N., Jalali, M., Garzia, L., Jabado, N., & Rak, J. W. (2026) · Journal of Extracellular Biology · doi:10.1002/jex2.70152 · Cited by 2

Screening and molecular mechanism research on bile microRNAs associated with chemotherapy efficacy in perihilar cholangiocarcinoma

Fu, S., Du, H., Dai, Y., Zheng, K., Cao, G., Xu, L., Zhong, Y., Niu, C., Kong, Y., & Wang, X. (2024) · iScience · doi:10.1016/j.isci.2024.111437 · Cited by 2

Phosphopeptidome Profiling of Human Plasma for Hepatocellular Carcinoma Biomarker Discovery

Saleem, S. M., Sajid, M. S., Varghese, R. S., Sherif, Z. A., Kroemer, A., & Ressom, H. W. (2025) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5c01004 · Cited by 1

Therapeutic targeting of cancer stem cell-specific surface glycans and glycoproteins

Al‐Khreisat, M. J., Abdulsahib, W. K., Jasim, I. K., Malathi, H., Nayak, P. P., Anand, D. A., Mukherjee, G., Sinha, A., & Ruziyeva, G. (2026) · Discover Oncology · doi:10.1007/s12672-026-04586-0 · Cited by 1

Liquid biopsy in pediatric acute lymphoblastic leukemia

Chen, Y., Wang, J., Ye, C., Xu, X., Yue, M., & Zhao, X. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1853549 · Cited by 1

Circulating Tumor DNA Methylation Profiling for Early Diagnosis and Treatment Monitoring in Rhabdomyosarcoma: A Prospective Cohort StudyPreprint

Li, Q., Luo, S., Jiang, S., Zhang, J., Lin, H., Xie, Y., & Liu, M. (2026) · Research Square · doi:10.21203/rs.3.rs-9067616/v1 · Cited by 1

Basic Science, New Target Investigation, and Research in Childhood Cancer

Abdelhafeez, A. H., & Santana, V. M. (2025) · Springer eBooks · doi:10.1007/978-3-030-71113-9_52-1

Cell-free DNA methylome and fragmentome analysis for disease relapse monitoring in patients with Ewing Sarcoma

Richardson, S. A., Gulati, G., Harker, P. J. B., Redfern, A., Pearce, S. P., Karimpour, M., Hill, S. M., Makeev, V. J., Brennan, B., Lee, A. T., et al. (2025) · doi:10.1101/2025.04.25.25325254

Basic Science, New Target Investigation, and Research in Childhood Cancer

Abdelhafeez, A. H., & Santana, V. M. (2025) · Springer eBooks · doi:10.1007/978-3-030-71113-9_52-2

Basic Science, New Target Investigation, and Research in Childhood Cancer

Abdelhafeez, A. H., & Santana, V. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-76882-8_52

The use of plasma miRNAs to better manage pediatric brain gliomas

Coppes, M. J. (2025) · Pediatric Research · doi:10.1038/s41390-025-04544-6

Identification of coilin in bone marrow as a potential neuroblastoma tumor progression marker transcriptionally regulated by MYCN

Yue, Z., Li, L., Liu, S. P., Gao, C., He, S., Xue, T., Zhao, W., Cui, C., Duan, C., & Su, Y. (2025) · Cancer Biology & Therapy · doi:10.1080/15384047.2025.2600709

Cell-Free DNA Uncovered Tumor Heterogeneity and Informed Targeted Therapy in a Pediatric Rhabdomyosarcoma

Faucher, J., Richer, C., Langlois, S., Rouette, A., Bianco, S., Sontag, T., Lepage, M.-E., Silva, E. D., Cellot, S., Tran, T. H., et al. (2026) · JCO Precision Oncology · doi:10.1200/po-25-00948

Biomarkers for Diagnosis, Risk Stratification, and Immunotherapy of Pediatric Solid Tumors

Kościelniak, E., Janeway, K., & Gottschalk, S. M. (2026) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk-26-519040

Multi-omics analysis identifies stemness-driven molecular subtypes, prognostic signature, epigenetic target APCDD1, and drug candidate Leflunomide in Wilms tumor

Du, H., Zheng, Y. N., Zhu, C., Guo, Y., Li, P., & Hong, P. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1775326

Molecular and biochemical profile of testicular germ cell tumors: Diagnostic implicationsPreprint

Shahini, L., Haxhibeqiri, V., Kabashi, K., Gjocaj, M., Ukelli, S., Kabashi, E., Haxhibeqiri, S., & Haziri, I. (2026) · Research Square · doi:10.21203/rs.3.rs-9808339/v1

Current Perspective: The Role of Liquid Biopsy in Diagnosis and Management of Pediatric Rhabdomyosarcomas (RMS)

Lehovsky, K., Putnam, C., Hall, N. J., Gray, J., & Walters, Z. S. (2026) · Pediatric Hematology and Oncology · doi:10.1080/08880018.2026.2696405

Advances in the association between tumor immune microenvironment remodeling in osteosarcoma and the risk of pathological fractures

Yang, Y. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2026.1882506

CX3CL1/CX3CR1 signaling in spinal metastasis: mechanisms and translational opportunities

Sanker, V., Li, Z., Urdaneta, A., Dravid, A., Heesen, P., Frantzias, J., Cavagnaro, M. J., Ratliff, J. K., Mathews, I. I., & Desai, A. M. (2026) · Clinical & Experimental Metastasis · doi:10.1007/s10585-026-10427-9

Minimal residual disease and relapse surveillance in osteosarcoma: an action-linked framework integrating liquid biopsy and imaging biomarkers

Huang, G., Zhou, Y., Wang, H., & Xiucai, M. (2026) · Journal of bone oncology · doi:10.1016/j.jbo.2026.100803

Pediatric non-gestational choriocarcinoma: a call for disease-specific treatment protocols

Arif, A., Ali, S., Lohana, I., & Abbas, S. (2026) · Journal of Gynecologic Oncology · doi:10.3802/jgo.2026.37.e146

Testicular Cancer

Eleveld, T. F., Janssen, F. W., Mego, M., & Looijenga, L. H. J. (2026) · Endocrinology · doi:10.1007/978-3-319-29456-8_48-1

Progress toward liquid biopsies in pediatric solid tumors

Weiser, D. A., West-Szymanski, D. C., Fraint, E., Weiner, S., Rivas, M. A., Zhao, C. W. T., He, C., & Applebaum, M. A. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09825-1 · Cited by 61

The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children: a review

Paemel, R. V., Vlug, R., Preter, K. D., Roy, N. V., Speleman, F., Willems, L., Lammens, T., Laureys, G., Schleiermacher, G., Tytgat, G. A. M., et al. (2020) · European Journal of Pediatrics · doi:10.1007/s00431-019-03545-y · Cited by 68

Case series on clinical applications of liquid biopsy in pediatric solid tumors: towards improved diagnostics and disease monitoring

Gelineau, N. U., van Barneveld, A., Samim, A., van Zogchel, L. M. J., Lak, N. S. M., Tas, M. L., Matser, Y. A. H., Mavinkurve‐Groothuis, A. M. C., van Grotel, M., Zsiros, J., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1209150 · Cited by 17

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Kościelniak, E., Janeway, K., & Gottschalk, S. M. (2026) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk-26-519040

Liquid biopsies in pediatric solid tumors

van Zogchel, L. M. J. (2025) · doi:10.33540/3061