Ewing sarcoma

Bone marrow transplant

Szer, J. (1999) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1999.tb127745.x · Cited by 3,376 · see citing works

Histone methylation: a dynamic mark in health, disease and inheritance

Greer, E. L., & Shi, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3173 · Cited by 2,241 · see citing works

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

Delattre, O., Zucman, J., Plougastel, B., Desmaze, C., Melot, T., Peter, M., Kovar, H., Joubert, I., de Jong, P., Rouleau, G., et al. (1992) · Nature · doi:10.1038/359162a0 · Cited by 1,907 · see citing works

Targeting EZH2 in cancer

Kim, K. H., & Roberts, C. W. M. (2016) · Nature Medicine · doi:10.1038/nm.4036 · Cited by 1,471 · see citing works

Germline Mutations in Predisposition Genes in Pediatric Cancer

Zhang, J., Walsh, M. F., Wu, G., Edmonson, M. N., Gruber, T. A., Easton, J., Hedges, D., Ma, X., Zhou, X., Yergeau, D. A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1508054 · Cited by 1,345 · see citing works

MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells

Xu, N., Papagiannakopoulos, T. Y., Pan, G., Thomson, J. A., & Kosik, K. S. (2009) · Cell · doi:10.1016/j.cell.2009.02.038 · Cited by 1,128 · see citing works

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

Shi, J., & Vakoc, C. R. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.016 · Cited by 881 · see citing works

Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics

Kadoch, C., & Crabtree, G. R. (2015) · Science Advances · doi:10.1126/sciadv.1500447 · Cited by 843 · see citing works

JHDM2A, a JmjC-Containing H3K9 Demethylase, Facilitates Transcription Activation by Androgen Receptor

Yamane, K., Toumazou, C., Tsukada, Y.-I., Erdjument‐Bromage, H., Tempst, P., Wong, J., & Zhang, Y. (2006) · Cell · doi:10.1016/j.cell.2006.03.027 · Cited by 840 · see citing works

Randomized Controlled Trial of Interval-Compressed Chemotherapy for the Treatment of Localized Ewing Sarcoma: A Report From the Children's Oncology Group

Womer, R. B., West, D. C., Krailo, M., Dickman, P. S., Pawel, B., Grier, H. E., Marcus, K. J., Sailer, S. L., Healey, J. H., Dormans, J. P., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.41.5703 · Cited by 761 · see citing works

A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS–family transcription factor, ERG

Sorensen, P. H. B., Lessnick, S. L., Lopez-Terrada, D. H., Liu, X. F., Triche, T. J., & Denny, C. T. (1994) · Nature Genetics · doi:10.1038/ng0294-146 · Cited by 747 · see citing works

Ewing Sarcoma: Current Management and Future Approaches Through Collaboration

Gaspar, N., Hawkins, D. S., Dirksen, U., Lewis, I. J., Ferrari, S., Deley, M. L., Kovar, H., Grimer, R. J., Whelan, J. S., Claude, L., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.59.5256 · Cited by 725 · see citing works

Realizing the promise of cancer predisposition genes

Rahman, N. (2014) · Nature · doi:10.1038/nature12981 · Cited by 616 · see citing works

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

Eirew, P. D., Steif, A., Khattra, J. S., Ha, G., Yap, D., Farahani, H., Gelmon, K. A., Chia, S., Mar, C., Wan, A., et al. (2014) · Nature · doi:10.1038/nature13952 · Cited by 585 · see citing works

The Genomic Landscape of Pediatric Ewing Sarcoma

Crompton, B. D., Stewart, C., Taylor-Weiner, A. N., Alexe, G., Kurek, K. C., Calicchio, M. L., Kieżun, A., Carter, S. L., Shukla, S. A., Mehta, S. S., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-1037 · Cited by 573 · see citing works

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

May, W. A., Gishizky, M. L., Lessnick, S. L., Lunsford, L. B., Lewis, B. C., Delattre, O., Zucman‐Rossi, J., Thomas, G. D., & Denny, C. T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5752 · Cited by 572 · see citing works

Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations

Tirode, F., Surdez, D., Ma, X., Parker, M. D., Deley, M. L., Bahrami, A., Zhang, Z., Lapouble, E., Grossetête, S., Rusch, M., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0622 · Cited by 569 · see citing works

Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation

Edmunds, J. W., Mahadevan, L. C., & Clayton, A. L. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601967 · Cited by 547 · see citing works

Cancer biology and NuRD: a multifaceted chromatin remodelling complex

Lai, A. Y., & Wade, P. A. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3091 · Cited by 541 · see citing works

Combinatorial generation of variable fusion proteins in the Ewing family of tumours.

Zucman‐Rossi, J., Melot, T., Desmaze, C., Ghysdael, J., Plougastel-Douglas, B., Peter, M., Zucker, J. M., Triche, T. J., Sheer, D., & Turc‐Carel, C. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06137.x · Cited by 540 · see citing works

Primary Disseminated Multifocal Ewing Sarcoma: Results of the Euro-EWING 99 Trial

Ladenstein, R. L., Pötschger, U., Deley, M. L., Whelan, J. S., Paulussen, M., Oberlin, O., van den Berg, H., Dirksen, U., Hjorth, L., Michon, J. M., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.9864 · Cited by 538 · see citing works

EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma.

de Álava, E., Kawai, A., Healey, J. H., Fligman, I., Meyers, P. A., Huvos, A. G., Gerald, W. L., Jhanwar, S. C., Argani, P., Antonescu, C. R., et al. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.4.1248 · Cited by 522 · see citing works

Non-coding RNAs as direct and indirect modulators of epigenetic regulation

Peschansky, V. J., & Wahlestedt, C. (2013) · Epigenetics · doi:10.4161/epi.27473 · Cited by 516 · see citing works

Mesenchymal Stem Cell Features of Ewing Tumors

Tirode, F., Laud-Duval, K., Prieur, A., Delorme, B., Charbord, P., & Delattre, O. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.02.027 · Cited by 506 · see citing works

BCoR, a novel corepressor involved in BCL-6 repressionPreprint

Huynh, K. D., Fischle, W., Verdin, E. M., & Bardwell, V. J. (2000) · Genes & Development · doi:10.1101/gad.14.14.1810 · Cited by 475 · see citing works

A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion

Pierron, G., Tirode, F., Lucchesi, C., Reynaud, S., Ballet, S., Cohen‐Gogo, S., Perrin, V., Coindre, J., & Delattre, O. (2012) · Nature Genetics · doi:10.1038/ng.1107 · Cited by 475 · see citing works

Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain

Boulay, G., Sandoval, G. J., Riggi, N., Iyer, S., Buisson, R., Naigles, B., Awad, M. E., Rengarajan, S., Volorio, A., McBride, M. J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.036 · Cited by 474 · see citing works

A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.

Jeon, I. S., Davis, J. N., Braun, B. S., Sublett, J. E., Roussel, M. F., Denny, C. T., & Shapiro, D. N. (1995) · PubMed · Cited by 471 · see citing works

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

Erkizan, H. V., Kong, Y., Merchant, M. S., Schlottmann, S., Barber-Rotenberg, J. S., Yuan, L., Abaan, O. D., Chou, T.-F., Dakshanamurthy, S., Brown, M. L., et al. (2009) · Nature Medicine · doi:10.1038/nm.1983 · Cited by 450 · see citing works

EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma

Riggi, N., Knoechel, B., Gillespie, S. M., Rheinbay, E., Boulay, G., Suvà, M. L., Rossetti, N. E., Boonseng, W. E., Oksuz, O., Cook, E., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.004 · Cited by 447 · see citing works

The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation

Brohl, A. S., Solomon, D. A., Chang, W., Wang, J., Song, Y., Sindiri, S., Patidar, R., Hurd, L., Chen, L., Shern, J. F., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004475 · Cited by 440 · see citing works

Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer

Solomon, D. A., Kim, T., Díaz-Martínez, L. A., Fair, J., ELKAHLOUN, A. G., Harris, B. T., Toretsky, J. A., Rosenberg, S. A., Shukla, N. N., Ladanyi, M., et al. (2011) · Science · doi:10.1126/science.1203619 · Cited by 430 · see citing works

Sarcoma classification: An update based on the 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone

Doyle, L. A. (2014) · Cancer · doi:10.1002/cncr.28657 · Cited by 423 · see citing works

Sarcomas With CIC-rearrangements Are a Distinct Pathologic Entity With Aggressive Outcome

Antonescu, C. R., Owosho, A. A., Zhang, L., Chen, S. D., Denız, K., Huryn, J. M., Kao, Y., Huang, S., Singer, S., Tap, W. D., et al. (2017) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000846 · Cited by 407 · see citing works

A new member of the ETS family fused to EWS in Ewing tumors

Peter, M., Couturier, J., Pacquement, H., Michon, J. M., Thomas, G. D., Magdelénat, H., & Delattre, O. (1997) · Oncogene · doi:10.1038/sj.onc.1200933 · Cited by 397 · see citing works

Chromatin crosstalk in development and disease: lessons from REST

Ooi, L., & Wood, I. C. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2100 · Cited by 395 · see citing works

Positron Emission Tomography for Staging of Pediatric Sarcoma Patients: Results of a Prospective Multicenter Trial

Völker, T., Denecke, T., Steffen, I. G., Misch, D., Schönberger, S., Plotkin, M., Ruf, J., Furth, C., Stöver, B., Hautzel, H., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.2473 · Cited by 395 · see citing works

Initial Symptoms and Clinical Features in Osteosarcoma and Ewing Sarcoma*

Widhe, B., & Widhe, T. L. (2000) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200005000-00007 · Cited by 378 · see citing works

Development of Ewing's Sarcoma from Primary Bone Marrow–Derived Mesenchymal Progenitor Cells

Riggi, N., Cironi, L., Provero, P., Suvà, M.-L., Kaloulis, K., Garcı́a-Echeverrı́a, C., Hoffmann, F., Trumpp, A., & Stamenkovic, I. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1696 · Cited by 355 · see citing works

Local therapy in localized Ewing tumors: results of 1058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials

Schuck, A., Ahrens, S., Paulussen, M., Kuhlen, M., Könemann, S., Rübe, C., Winkelmann, W., Kotz, R. I., Dunst, J., Willich, N. A., et al. (2002) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)03797-5 · Cited by 348 · see citing works

Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein

Hahm, K., Cho, K., Lee, C., Im, Y., Chang, J., Choi, S.-G., Sorensen, P. H. B., Thiele, C. J., & Kim, S. (1999) · Nature Genetics · doi:10.1038/13854 · Cited by 347 · see citing works

Transcriptomic definition of molecular subgroups of small round cell sarcomas

Watson, S., Perrin, V., Guillemot, D., Reynaud, S., Coindre, J., Karanian, M., Guinebretière, J., Fréneaux, P., Loarer, F. L., Bouvet, M., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5053 · Cited by 335 · see citing works

EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma

Gorthi, A., Romero, J. C., Loranc, E., Cao, L., Lawrence, L. A., Goodale, E., Iniguez, A. B., Bernard, X., Masamsetti, V. P., Roston, S. R., et al. (2018) · Nature · doi:10.1038/nature25748 · Cited by 333 · see citing works

Regulation of gene transcription by Polycomb proteins

Aranda, S., Martín, G. M., & Croce, L. D. (2015) · Science Advances · doi:10.1126/sciadv.1500737 · Cited by 332 · see citing works

EWS-FLI-1 Expression Triggers a Ewing's Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells

Riggi, N., Suvà, M.-L., Suvà, D., Cironi, L., Provero, P., Tercier, S., Joseph, J., Stehle, J., Baumer, K., Kindler, V., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-1761 · Cited by 330 · see citing works

Next-generation personalised medicine for high-risk paediatric cancer patients – The INFORM pilot study

Worst, B. C., van Tilburg, C. M., Balasubramanian, G. P., Fiesel, P., Witt, R., Freitag, A., Boudalil, M., Previti, C., Wolf, S., Schmidt, S., et al. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.06.009 · Cited by 329 · see citing works

Risk of recurrence and survival after relapse in patients with Ewing sarcoma

Stahl, M., Ranft, A., Paulussen, M., Bölling, T., Vieth, V., Bielack, S., Görtitz, I., Braun‐Munzinger, G., Hardes, J., Jürgens, H., et al. (2011) · Pediatric Blood & Cancer · doi:10.1002/pbc.23040 · Cited by 316 · see citing works

SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions

Zhang, T., & Kraus, W. L. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.10.022 · Cited by 306 · see citing works

EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

Richter, G. H. S., Plehm, S., Fasan, A., Rössler, S., Unland, R., Bennani-Baı̈ti, I. M., Hotfilder, M., Löwel, D., von Luettichau, I., Moßbrugger, I., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810759106 · Cited by 304 · see citing works

Microsatellites as EWS/FLI response elements in Ewing's sarcoma

Gangwal, K., Sankar, S., Hollenhorst, P. C., Kinsey, M., Haroldsen, S. C., Shah, A. A., Boucher, K. M., Watkins, W. S., Jorde, L. B., Graves, B. J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801073105 · Cited by 297 · see citing works

MicroRNA-34a: a potential therapeutic target in human cancer

Li, X. J., Ren, Z. J., & Tang, J. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.270 · Cited by 286 · see citing works

Orthotopic patient-derived xenografts of paediatric solid tumours

Stewart, E., Federico, S. M., Chen, X., Shelat, A. A., Bradley, C., Gordon, B., Karlstrom, A., Twarog, N. R., Clay, M. R., Bahrami, A., et al. (2017) · Nature · doi:10.1038/nature23647 · Cited by 286 · see citing works

Safety assessment of intensive induction with vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) in the treatment of Ewing tumors in the EURO‐E.W.I.N.G. 99 clinical trial

Juergens, C., Weston, C. L., Lewis, I. J., Whelan, J. S., Paulussen, M., Oberlin, O., Michon, J. M., Zoubek, A., Juergens, H., & Craft, A. W. (2006) · Pediatric Blood & Cancer · doi:10.1002/pbc.20820 · Cited by 282 · see citing works

Ewing sarcoma demonstrates racial disparities in incidence‐related and sex‐related differences in outcome

Jawad, M. U., Cheung, M. C., Min, E. S., Schneiderbauer, M. M., Koniaris, L. G., & Scully, S. P. (2009) · Cancer · doi:10.1002/cncr.24388 · Cited by 281 · see citing works

Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis

El-Naggar, A. M., Veinotte, C. J., Cheng, H., Grünewald, T. G. P., Negri, G. L., Somasekharan, S. P., Corkery, D., Tirode, F., Mathers, J. A., Khan, D., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.003 · Cited by 280 · see citing works

YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1

Somasekharan, S. P., El-Naggar, A. M., Leprivier, G., Cheng, H., Hajee, S., Grünewald, T. G. P., Zhang, F., Ng, T., Delattre, O., Evdokimova, V. E., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201411047 · Cited by 279 · see citing works

EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cellsPreprint

Riggi, N., Suvà, M.-L., Vito, C. D., Provero, P., Stehle, J., Baumer, K., Cironi, L., Janiszewska, M., Petricevic, T., Suvà, D., et al. (2010) · Genes & Development · doi:10.1101/gad.1899710 · Cited by 279 · see citing works

BCOR-CCNB3 Fusion Positive Sarcomas

Kao, Y., Owosho, A. A., Sung, Y., Zhang, L., Fujisawa, Y., Lee, J., Wexler, L. H., Argani, P., Swanson, D. M., Dickson, B. C., et al. (2017) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000965 · Cited by 275 · see citing works

Promiscuous partnerships in Ewing's sarcoma

Sankar, S., & Lessnick, S. L. (2011) · Cancer Genetics · doi:10.1016/j.cancergen.2011.07.008 · Cited by 260 · see citing works

Condensin and cohesin complexity: the expanding repertoire of functions

Wood, A. J., Severson, A. F., & Meyer, B. J. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2794 · Cited by 254 · see citing works

DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma

Sheffield, N. C., Pierron, G., Klughammer, J., Datlinger, P., Schönegger, A., Schuster, M. K., Hadler, J. S., Surdez, D., Guillemot, D., Lapouble, E., et al. (2017) · Nature Medicine · doi:10.1038/nm.4273 · Cited by 254 · see citing works

Ewing Sarcomas With p53 Mutation or p16/p14ARF Homozygous Deletion: A Highly Lethal Subset Associated With Poor Chemoresponse

Huang, H.-Y., Illei, P. B., Zhao, Z., Mazumdar, M., Huvos, A. G., Healey, J. H., Wexler, L. H., Gorlick, R. G., Meyers, P. A., & Ladanyi, M. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.081 · Cited by 247 · see citing works

The Insulin-like Growth Factor-I Receptor Is Required for EWS/FLI-1 Transformation of Fibroblasts

Toretsky, J. A., Kalebic, T., Blakesley, V., LeRoith, D., & Helman, L. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.49.30822 · Cited by 246 · see citing works

Ewing's tumors with primary lung metastases: survival analysis of 114 (European Intergroup) Cooperative Ewing's Sarcoma Studies patients.

Paulussen, M., Ahrens, S., Craft, A. W., Dunst, J., Fröhlich, B., Jabar, S., Rübe, C., Winkelmann, W., Wissing, S., Zoubek, A., et al. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.9.3044 · Cited by 246 · see citing works

Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1

Tomazou, E. M., Sheffield, N. C., Schmidl, C., Schuster, M. K., Schönegger, A., Datlinger, P., Kubicek, S., Bock, C., & Kovar, H. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.042 · Cited by 242 · see citing works

Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target.

Scotlandi, K., Benini, S., Sarti, M., Serra, M., Lollini, P., Maurici, D., Picci, P., Manara, M. C., & Baldini, N. (1996) · PubMed · Cited by 227 · see citing works

Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells

Franzetti, G.-A., Laud-Duval, K., van der Ent, W., Brisac, A., Irondelle, M., Aubert, S., Dirksen, U., Bouvier, C., Pinieux, G. D. B. D., Snaar-Jagalska, E. B., et al. (2017) · Oncogene · doi:10.1038/onc.2016.498 · Cited by 224 · see citing works

The Oncogenic EWS-FLI1 Protein Binds In Vivo GGAA Microsatellite Sequences with Potential Transcriptional Activation Function

Guillon, N., Tirode, F., Boeva, V., Zynovyev, A., Barillot, E., & Delattre, O. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004932 · Cited by 218 · see citing works

Histological heterogeneity of Ewing’s sarcoma/PNET: an immunohistochemical analysis of 415 genetically confirmed cases with clinical support

Llombart‐Bosch, A., Machado, I., Navarro, S., Bertoni, F., Bacchini, P., Alberghini, M., Karzeladze, A., Савелов, Н. А., Petrov, S., Alvarado‐Cabrero, I., et al. (2009) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-009-0842-7 · Cited by 217 · see citing works

Translocation involving chromosome 22 in Ewing's Sarcoma. A cytogenetic study of four fresh tumors

Aurias, A., Rimbaut, C., Buffe, D., Zucker, J., & Mazabraud, A. (1984) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(84)90003-7 · Cited by 214 · see citing works

FDG-PET for detection of pulmonary metastases from malignant primary bone tumors: Comparison with spiral CT

Franzius, C., Daldrup-Link, H. E., Sciuk, J., Rummeny, E., Bielack, S., Jürgens, H., & Schober, O. (2001) · Annals of Oncology · doi:10.1023/a:1011111322376 · Cited by 211 · see citing works

Increased Risk of Systemic Relapses Associated With Bone Marrow Micrometastasis and Circulating Tumor Cells in Localized Ewing Tumor

Schleiermacher, G., Peter, M., Oberlin, O., Philip, T. O., Rubie, H., Mechinaud, F. M., Sommelet-Olive, D., Landman‐Parker, J., Bours, D., Michon, J. M., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2003.03.006 · Cited by 210 · see citing works

DNA Microarrays Reveal Relationship of Ewing Family Tumors to Both Endothelial and Fetal Neural Crest-Derived Cells and Define Novel Targets

Staege, M. S., Hutter, C., Neumann, I., Foja, S., Hattenhorst, U. E., Hansen, G., Afar, D., & Burdach, S. E. G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-4059 · Cited by 209 · see citing works

Preliminary Efficacy of the Anti-Insulin–Like Growth Factor Type 1 Receptor Antibody Figitumumab in Patients With Refractory Ewing Sarcoma

Juergens, H., Daw, N. C., Geoerger, B., Ferrari, S., Milena Villarroel, C., Aerts, I., Whelan, J. S., Dirksen, U., Hixon, M. L., Yin, D., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.0670 · Cited by 208 · see citing works

High-Dose Melphalan, Etoposide, Total-Body Irradiation, and Autologous Stem-Cell Reconstitution as Consolidation Therapy for High-Risk Ewing’s Sarcoma Does Not Improve Prognosis

Meyers, P. A., Krailo, M., Ladanyi, M., Chan, K., Sailer, S. L., Dickman, P. S., Baker, D. L., Davis, J. H., Gerbing, R. B., Grovas, A. C., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.11.2812 · Cited by 205 · see citing works

The NFATc2 Gene Is Involved in a Novel Cloned Translocation in a Ewing Sarcoma Variant That Couples Its Function in Immunology to Oncology

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A clinicopathologic study of 20 cases of large-cell (atypical) Ewingʼs sarcoma of bone

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ERBB4 confers metastatic capacity in Ewing sarcoma

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ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repairPreprint

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An evaluation of [F‐18]‐fluorodeoxy‐ D ‐glucose positron emission tomography, bone scan, and bone marrow aspiration/biopsy as staging investigations in Ewing Sarcoma

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Zoledronic Acid as a New Adjuvant Therapeutic Strategy for Ewing's Sarcoma Patients

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Frequent inactivating germline mutations in DNA repair genes in patients with Ewing sarcoma

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Ewing’s sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors

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A Novel Corepressor, BCoR-L1, Represses Transcription through an Interaction with CtBP

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Histone deacetylase inhibitors induce cell death and enhance the apoptosis-inducing activity of TRAIL in Ewing’s sarcoma cells

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Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells

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Longitudinal follow‐up of adult survivors of Ewing sarcoma: A report from the Childhood Cancer Survivor Study

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Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growth

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Molecular Analysis of Ewing's Sarcoma: Another Fusion Gene, EWS‐E1AF, Available for Diagnosis

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RARITY OF EWING'S SARCOMA AMONG U.S. NEGRO CHILDREN

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A zebrafish transgenic model of Ewing’s sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis

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Ploidy and karyotype complexity are powerful prognostic indicators in the Ewing's sarcoma family of tumors: A study by the United Kingdom Cancer Cytogenetics and the Children's Cancer and Leukaemia Group

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Hypoxia Modulates EWS-FLI1 Transcriptional Signature and Enhances the Malignant Properties of Ewing's Sarcoma Cells In vitro

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The histone demethylase KDM3A, and its downstream target MCAM, promote Ewing Sarcoma cell migration and metastasis

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EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma

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First identification of Ewing's sarcoma‐derived extracellular vesicles and exploration of their biological and potential diagnostic implications

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Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting

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EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma

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Suppression of Deacetylase SIRT1 Mediates Tumor-Suppressive NOTCH Response and Offers a Novel Treatment Option in Metastatic Ewing Sarcoma

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Emergent Properties of EWS/FLI Regulation via GGAA Microsatellites in Ewing's Sarcoma

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Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1–PI3K–Rac1 pathway

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Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma

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PARP Inhibitors Sensitize Ewing Sarcoma Cells to Temozolomide-Induced Apoptosis via the Mitochondrial Pathway

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Fractures in Pediatric Ewing Sarcoma

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Inhibition of the oncogenic fusion protein EWS-FLI1 causes G 2 -M cell cycle arrest and enhanced vincristine sensitivity in Ewing’s sarcoma

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Review with novel markers facilitates precise categorization of 41 cases of diagnostically challenging, “undifferentiated small round cell tumors”. A clinicopathologic, immunophenotypic and molecular analysis

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ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma

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Flow cytometric detection of Ewing sarcoma cells in peripheral blood and bone marrow

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DKK2 Mediates Osteolysis, Invasiveness, and Metastatic Spread in Ewing Sarcoma

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Definitive Radiotherapy for Ewing Tumors of Extremities and Pelvis: Long-Term Disease Control, Limb Function, and Treatment Toxicity

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Carboplatin in the treatment of Ewing sarcoma: Results of the first Brazilian Collaborative Study Group for Ewing Sarcoma Family Tumors-EWING1

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The value of high‐dose chemotherapy in patients with first relapsed Ewing sarcoma

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A link between basic fibroblast growth factor (bFGF) and EWS/FLI-1 in Ewing's sarcoma cells

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Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma

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Local Control in Ewing Sarcoma of the Chest Wall: Results of the EURO-EWING 99 Trial

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G‐Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1

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Stress-Induced CXCR4 Promotes Migration and Invasion of Ewing Sarcoma

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Impact of IGF-I/IGF-IR Circuit on the Angiogenetic Properties of Ewing’s Sarcoma Cells

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Racial Differences in the Incidence of Mesenchymal Tumors Associated with EWSR1 Translocation

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Pilot Trial of FANG Immunotherapy in Ewing's Sarcoma

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Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing's sarcoma cells

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A framework for understanding the functions of biomolecular condensates across scales

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Current advance of nanotechnology in diagnosis and treatment for malignant tumors

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Ewing’s Sarcoma

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Ewing Sarcoma—Diagnosis, Treatment, Clinical Challenges and Future Perspectives

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Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden

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Advances in immune checkpoint inhibitors for bone sarcoma therapy

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Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours

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Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution

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High-Dose Chemotherapy Compared With Standard Chemotherapy and Lung Radiation in Ewing Sarcoma With Pulmonary Metastases: Results of the European Ewing Tumour Working Initiative of National Groups, 99 Trial and EWING 2008

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TP53 in bone and soft tissue sarcomas

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Fixation can change the appearance of phase separation in living cells

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Childhood Cancer: Occurrence, Treatment and Risk of Second Primary Malignancies

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Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma

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STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma.

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Engineering the Bridge between Innate and Adaptive Immunity for Cancer Immunotherapy: Focus on γδ T and NK Cells

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Inhibition of the ATR–CHK1 Pathway in Ewing Sarcoma Cells Causes DNA Damage and Apoptosis via the CDK2-Mediated Degradation of RRM2

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Prognostic profiling of the immune cell microenvironment in Ewing´s Sarcoma Family of Tumors

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Ewing Sarcoma-Derived Extracellular Vesicles Impair Dendritic Cell Maturation and Function

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