Deletion of neural estrogen receptor alpha induces sex differential effects on reproductive behavior in mice
Open accessAbstract
Estrogen receptor (ER) α is involved in several estrogen-modulated neural and peripheral functions. To determine its role in the expression of female and male reproductive behavior, a mouse line lacking the ERα in the nervous system was generated. Mutant females did not exhibit sexual behavior despite normal olfactory preference, and had a reduced number of progesterone receptor-immunoreactive neurons in the ventromedial hypothalamus. Mutant males displayed a moderately impaired sexual behavior and unaffected fertility, despite evidences of altered organization of sexually dimorphic populations in the preoptic area. In comparison, males deleted for both neural ERα and androgen receptor (AR) displayed greater sexual deficiencies. Thus, these data highlight a predominant role for neural ERα in females and a complementary role with the AR in males in the regulation of sexual behavior, and provide a solid background for future analyses of neuronal versus glial implication of these signaling pathways in both sexes.
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The impairments in male copulatory behavior following play deprivation were close to the magnitude seen in other studies in which male copulatory behavior is altered by more substantial pharmacological or genetic manipulations.
“Remarkably, these impairments were close to the magnitude seen in other studies in which male copulatory behavior is altered by more substantial pharmacological or genetic manipulations”
From Social play experience in juvenile rats is indispensable for appropriate socio-sexual behavior in adulthood in males but not females (2023) · cites this paper as Trouillet et al., 2022
The Results section, under “Double neural AR and ERα knockout severely impaired male sexual behavior in mice” (page unavailable), reports substantial changes in male mating behavior after a genetic manipulation. The paper does not examine play deprivation or compare its effects with the knockout effects, so it cannot establish the claimed similarity in magnitude. (LLM, conf=0.82)
Experimental — accuracy not yet measuredThe reduction in the percentage of animals successfully ejaculating was similar to that seen in males in which both the androgen receptor and estrogen receptor alpha were genetically deleted.
“the reduction in the percentage of animals which successfully ejaculated we observed was similar to that seen in males in which both the androgen receptor and estrogen receptor alpha were genetically deleted (Trouillet et al., 2022).”
From Social play experience in juvenile rats is indispensable for appropriate socio-sexual behavior in adulthood in males but not females (2023) · cites this paper as Trouillet et al., 2022
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- Authors
- Trouillet, A.-C., Ducroq, S., Naulé, L., Capela, D., Parmentier, C., Radovick, S., Hardin-Pouzet, H., & Mhaouty-Kodja, S.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Rutgers, The State University of New Jersey (US)
- Venue
- Communications Biology
- Published
- 2022-04-20
- Volume
- 5
- Issue
- 1
- Pages
- 383-383
- ISSN
- 2399-3642 (ISSN-L)
- PMC
- PMC9021208
- OpenAlex
- W4224210277
- Cited by
- 39
- References
- 43
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 17 · 2023: 9 · 2022: 5
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Communications Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agence Nationale de la Recherche (ANR-09-CESA-006, ANR-programme blanc SVSE 7-2012)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- estrogen receptor alpha, sexual behavior, sex differences, androgen receptor, ventromedial hypothalamus, preoptic area, odor preference, fertility
- MeSH terms
- Animals, Female, Hypothalamus, Male, Neurons, Preoptic Area, Sexual Behavior, Animal, Estrogen Receptor alpha, Mice
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