The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis
Open accessAbstract
Atherosclerosis is a progressive vascular disease triggered by interplay between abnormal shear stress and endothelial lipid retention. A combination of these and, potentially, other factors leads to a chronic inflammatory response in the vessel wall, which is thought to be responsible for disease progression characterized by a buildup of atherosclerotic plaques. Yet molecular events responsible for maintenance of plaque inflammation and plaque growth have not been fully defined. Here we show that endothelial transforming growh factor β (TGF-β) signalling is one of the primary drivers of atherosclerosis-associated vascular inflammation. Inhibition of endothelial TGF-β signalling in hyperlipidemic mice reduces vessel wall inflammation and vascular permeability and leads to arrest of disease progression and regression of established lesions. These proinflammatory effects of endothelial TGF-β signalling are in stark contrast with its effects in other cell types and identify it as an important driver of atherosclerotic plaque growth and show the potential of cell-type-specific therapeutic intervention aimed at control of this disease. Chen et al. report that TGF-β signalling, although largely considered anti-inflammatory, has proinflammatory effects on endothelial cells. Inhibition of endothelial TGF-β signalling decreases atherosclerosis in mice and reverts established plaques, in part by decreasing endothelial-to-mesenchymal transitions.
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Smooth Muscle Cell Reprogramming in Aortic Aneurysms
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Self-citationSOX9 reprograms endothelial cells by altering the chromatin landscape
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Metadata
- Authors
- Chen, P.-Y., Qin, L., Li, G., Wang, Z., Dahlman, J. E., Malagon-Lopez, J., Gujja, S., Cilfone, N. A., Kauffman, K. J., Sun, L., Sun, H., Zhang, X., Aryal, B., Canfran-Duque, A., Liu, R., Kusters, P., Sehgal, A., Jiao, Y., Anderson, D. G., Gulcher, J., Fernandez-Hernando, C., Lutgens, E., Schwartz, M. A., Pober, J. S., Chittenden, T. W., Tellides, G., & Simons, M.
- Venue
- Nature Metabolism
- Published
- 2019-08-26
- Volume
- 1
- Issue
- 9
- Pages
- 912-926
- ISSN
- 2522-5812 (ISSN-L)
- OpenAlex
- W2970727076
- Cited by
- 346
- References
- 44
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, P.-Y., Qin, L., Li, G., Wang, Z., Dahlman, J. E., Malagon-Lopez, J., Gujja, S., Cilfone, N. A., Kauffman, K. J., Sun, L., Sun, H., Zhang, X., Aryal, B., Canfran-Duque, A., Liu, R., Kusters, P., Sehgal, A., Jiao, Y., Anderson, D. G., . . . Simons, M. (2019). Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Nature Metabolism. https://doi.org/10.1038/s42255-019-0102-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
