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Cited by 627Sirtuins and Resveratrol in MedicineBiochemical and Molecular ResearchCalcium signaling and nucleotide metabolism

The DOI matches its Crossref record; 456 of the 456 references it cites were found in a registry or an index.

NAD+ homeostasis in health and disease

Open access
Katsyuba, Elena, Romani, Mario, Hofer, Dina, Auwerx, Johan·2020·Nature Metabolism
DOI 10.1038/s42255-019-0161-5
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Abstract

The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and longevity, including the sirtuin family of protein deacylases, has led to a new wave of scientific interest in NAD+. NAD+ levels decline during ageing, and alterations in NAD+ homeostasis can be found in virtually all age-related diseases, including neurodegeneration, diabetes and cancer. In preclinical settings, various strategies to increase NAD+ levels have shown beneficial effects, thus starting a competitive race to discover marketable NAD+ boosters to improve healthspan and lifespan. Here, we review the basics of NAD+ biochemistry and metabolism, and its roles in health and disease, and we discuss current challenges and the future translational potential of NAD+ research.

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  1. Allegri, G., Costa, C.V.L., Ragazzi, E., Steinhart, H. & Laresio, L. Developments in Tryptophan and Serotonin Metabolism (Springer, 2012).
  2. Choi, S. H. et al. Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model. Science 361, eaan8821 (2018). · DOI · Paper page

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Metadata

Authors
Katsyuba, E., Romani, M., Hofer, D., & Auwerx, J.
Affiliations
  • École Polytechnique Fédérale de Lausanne (CH)
  • Thermo Fisher Scientific (Switzerland) (CH)
Corresponding author
Auwerx, Johan
ORCID
Venue
Nature Metabolism
Publisher
Springer Science and Business Media LLC
Published
2020-01-20
Volume
2
Issue
1
Pages
9-31
ISSN
2522-5812 (ISSN-L)
DOI
10.1038/s42255-019-0161-5
OpenAlex
W3000157665
Cited by
627
References
456
Citations by year
2026: 102 · 2025: 101 · 2024: 92 · 2023: 110 · 2022: 110 · 2021: 77 · 2020: 34
FWCI
10.28
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders
National Institute on Aging (R01AG043930)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords
NAD+ homeostasis, NAD+ metabolism, sirtuins, aging, age-related diseases, neurodegeneration, diabetes mellitus, cancer, healthspan, lifespan
MeSH terms
Animals, Disease, Glycolysis, Homeostasis, Humans, Longevity, Metabolism, NAD, NADP, Oxidation-Reduction, Phosphorylation, Subcellular Fractions, Sirtuins

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