Central and peripheral GLP-1 systems independently suppress eating

Brierley, Daniel I.; Holt, Marie K.; Singh, Arashdeep; de Araujo, Alan; McDougle, Molly; Vergara, Macarena; Afaghani, Majd H.; Lee, Shin Jae; Scott, Karen; Maske, Calyn; Langhans, Wolfgang; Krause, Eric; de Kloet, Annette; Gribble, Fiona M.; Reimann, Frank; Rinaman, Linda; de Lartigue, Guillaume; Trapp, Stefan

doi:10.1038/s42255-021-00344-4

Central and peripheral GLP-1 systems independently suppress eating

The anorexigenic peptide glucagon-like peptide-1 (GLP-1) is secreted from gut enteroendocrine cells and brain preproglucagon (PPG) neurons, which, respectively, define the peripheral and central GLP-1 systems. PPG neurons in the nucleus tractus solitarii (NTS) are widely assumed to link the perip…