Cited by 1,950Regulation of Appetite and ObesityNeuropeptides and Animal PhysiologyDiabetes Treatment and Management

A role for glucagon-like peptide-1 in the central regulation of feeding

Turton, M. D., O'Shea, D., Gunn, I., Beak, S. A., Edwards, C. M. B., Meeran, K., Choi, S. J., Taylor, G. M. +7 more·1996·Nature

Abstract

The sequence of glucagon-like peptide-1 (7-36) amide (GLP-1) is completely conserved in all mammalian species studied, implying that it plays a critical physiological role. We have shown that GLP-1 and its specific receptors are present in the hypothalamus. No physiological role for central GLP-1 has been established. We report here that intracerebroventricular (ICV) GLP-1 powerfully inhibits feeding in fasted rats. ICV injection of the specific GLP-1-receptor antagonist, exendin (9-39), blocked the inhibitory effect of GLP-1 on food intake. Exendin (9-39) alone had no influence on fast-induced feeding but more than doubled food intake in satiated rats, and augmented the feeding response to the appetite stimulant, neuropeptide Y. Induction of c-fos is a marker of neuronal activation. Following ICV GLP-1 injection, c-fos appeared exclusively in the paraventricular nucleus of the hypothalamus and central nucleus of the amygdala, and this was inhibited by prior administration of exendin (9-39). Both of these regions of the brain are of primary importance in the regulation of feeding. These findings suggest that central GLP-1 is a new physiological mediator of satiety.

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Crossref · 10.1038/379069a0

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21 of 21 references verified0 citation errors · 0 not checkable

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  • Enteroendocrine cells sense nutrients in the intestinal lumen and produce CCK, secretin, GIP, and GLP-1.

    “Enteroendocrine cells sense nutrients in the intestinal lumen and produce peptides such as cholecystokinin (CCK), secretin, and the incretins; glucose‐dependent insulinotropic peptide (GIP); and glucagon‐like peptide 1 (GLP‐1) 19, 20.”

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Authors
Turton, M. D., O'Shea, D., Gunn, I., Beak, S. A., Edwards, C. M. B., Meeran, K., Choi, S. J., Taylor, G. M., Heath, M. M., Lambert, P. D., Wilding, J. P. H., Smith, D. M., Ghatei, M. A., Herbert, J., & Bloom, S. R.
Affiliations
Hammersmith Hospital (GB)
Venue
Nature
Published
1996-01
Volume
379
Issue
6560
Pages
69-72
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2013082477
Cited by
1,950
References
21
Citations by year
2026: 35 · 2025: 60 · 2024: 87 · 2023: 55 · 2022: 48 · 2021: 66 · 2020: 55 · 2019: 63 · 2018: 62 · 2017: 69 · 2016: 70 · 2015: 76 · 2014: 92 · 2013: 87 · 2012: 87
FWCI
20.76
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
glucagon-like peptide-1, GLP-1 receptor, exendin-9-39, hypothalamus, food intake regulation, satiety, dietary intake, paraventricular nucleus, central amygdala, c-fos, neuropeptide Y, appetite, intracerebroventricular administration
MeSH terms
Animals, Cerebral Ventricles, Eating, Glucagon-Like Peptides, Glucagon, Injections, Intraventricular, Male, Neuropeptide Y, Peptide Fragments, Satiation, Proto-Oncogene Proteins c-fos, Rats, Glucagon-Like Peptide 1

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