Reimann, Frank

Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2

Tolhurst, G., Heffron, H., Lam, Y. S., Parker, H. E., Habib, A. M., Diakogiannaki, E., Cameron, J., Grosse, J., Reimann, F., & Gribble, F. M. (2012) · Diabetes

Diabetes Treatment and ManagementGut microbiota and health

Cited by 2,404

Glucagon-like peptide 1 (GLP-1)

Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism

Diabetes Treatment and ManagementRegulation of Appetite and Obesity

Cited by 1,868

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduction

Topaloglu, A. K., Reimann, F., Guclu, M., Yalin, A. S., Kotan, L. D., Porter, K. M., Serin, A., Mungan, N. O., Cook, J. R., Ozbek, M. N., et al. (2009) · Nature Genetics

Hypothalamic control of reproductive hormonesNeuropeptides and Animal Physiology

Cited by 961

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

Ellingsgaard, H., Hauselmann, I., Schuler, B., Habib, A. M., Baggio, L. L., Meier, D. T., Eppler, E., Bouzakri, K., Wueest, S., Muller, Y. D., et al. (2011) · Nature Medicine

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 922

Glucose Sensing in L Cells: A Primary Cell Study

Reimann, F., Habib, A. M., Tolhurst, G., Parker, H. E., Rogers, G. J., & Gribble, F. M. (2008) · Cell Metabolism

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 733

Na+-d-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

Gorboulev, V., Schürmann, A., Vallon, V., Kipp, H., Jaschke, A., Klessen, D., Friedrich, A., Scherneck, S., Rieg, T., Cunard, R., et al. (2012) · Diabetes

Diabetes Treatment and ManagementIon Transport and Channel Regulation

Cited by 687

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium

Gribble, F. M., & Reimann, F. (2016) · Annual Review of Physiology

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 683

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

Gribble, F. M., & Reimann, F. (2019) · Nature Reviews Endocrinology

Diabetes Treatment and ManagementRegulation of Appetite and Obesity

Cited by 670

Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis

Millonig, G., Reimann, F. M., Friedrich, S., Fonouni, H., Mehrabi, A., Büchler, M. W., Seitz, H. K., & Mueller, S. (2008) · Hepatology

Liver Disease Diagnosis and TreatmentUltrasound Imaging and Elastography

Cited by 599

GDF15 mediates the effects of metformin on body weight and energy balance

Coll, A. P., Chen, M., Taskar, P., Rimmington, D., Patel, S., Tadross, J. A., Cimino, I., Yang, M., Welsh, P., Virtue, S., et al. (2020) · Nature

GDF15 and Related BiomarkersRegulation of Appetite and Obesity

Cited by 584

Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells

Chimerel, C., Emery, E., Summers, D. K., Keyser, U., Gribble, F. M., & Reimann, F. (2014) · Cell Reports

Gut microbiota and healthPancreatic function and diabetes

Cited by 548

Sulfonylurea Stimulation of Insulin Secretion

Proks, P., Reimann, F., Green, N., Gribble, F., & Ashcroft, F. (2002) · Diabetes

Ion channel regulation and functionPancreatic function and diabetes

Cited by 510

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

Patel, S., Alvarez-Guaita, A., Melvin, A., Rimmington, D., Dattilo, A., Miedzybrodzka, E. L., Cimino, I., Maurin, A.-C., Roberts, G. P., Meek, C. L., et al. (2019) · Cell Metabolism

GDF15 and Related BiomarkersRegulation of Appetite and Obesity

Cited by 509

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain

Cork, S. C., Richards, J. E., Holt, M. K., Gribble, F. M., Reimann, F., & Trapp, S. (2015) · Molecular Metabolism

Regulation of Appetite and ObesityNeuropeptides and Animal Physiology

Cited by 478

Identification and characterization of GLP-1 receptor–expressing cells using a new transgenic mouse model

Richards, P., Parker, H. E., Adriaenssens, A. E., Hodgson, J. M., Cork, S. C., Trapp, S., Gribble, F. M., & Reimann, F. (2014) · Diabetes

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 472

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

Chera, S., Baronnier, D., Ghila, L., Cigliola, V., Jensen, J. N., Gu, G., Furuyama, K., Thorel, F., Gribble, F. M., Reimann, F., et al. (2014) · Nature

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 410

Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells

Parker, H. E., Habib, A. M., Rogers, G. J., Gribble, F. M., & Reimann, F. (2009) · Diabetologia

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 324

Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake

Adriaenssens, A. E., Biggs, E. K., Darwish, T., Tadross, J., Sukthankar, T., Girish, M., Polex-Wolf, J., Lam, B. Y., Zvetkova, I., Pan, W., et al. (2019) · Cell Metabolism

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 324

Sulphonylurea action revisited: the post-cloning era

Gribble, F. M., & Reimann, F. (2003) · Diabetologia

Ion channel regulation and functionPancreatic function and diabetes

Cited by 284

Central and peripheral GLP-1 systems independently suppress eating

Brierley, D. I., Holt, M. K., Singh, A., de Araujo, A., McDougle, M., Vergara, M., Afaghani, M. H., Lee, S. J., Scott, K., Maske, C., et al. (2021) · Nature Metabolism

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 265

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

Brereton, M. F., Iberl, M., Shimomura, K., Zhang, Q., Adriaenssens, A. E., Proks, P., Spiliotis, I. I., Dace, W., Mattis, K. K., Ramracheya, R., et al. (2014) · Nature Communications

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 259

GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis

De Marinis, Y. Z., Salehi, A., Ward, C. E., Zhang, Q., Abdulkader, F., Bengtsson, M., Braha, O., Braun, M., Ramracheya, R., Amisten, S., et al. (2010) · Cell Metabolism

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 257

Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes

Zhang, Q., Ramracheya, R., Lahmann, C., Tarasov, A., Bengtsson, M., Braha, O., Braun, M., Brereton, M., Collins, S., Galvanovskis, J., et al. (2013) · Cell Metabolism

Pancreatic function and diabetesIon channel regulation and function

Cited by 225

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

Adriaenssens, A. E., Svendsen, B., Lam, B. Y. H., Yeo, G. S. H., Holst, J. J., Reimann, F., & Gribble, F. M. (2016) · Diabetologia

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 223