The DOI matches its Crossref record; 216 of the 216 references it cites were found in a registry or an index.
Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding
Open accessAbstract
The overconsumption of highly caloric and palatable foods has caused a surge in obesity rates in the past half century, thereby posing a healthcare challenge due to the array of comorbidities linked to heightened body fat accrual. Developing treatments to manage body weight requires a grasp of the neurobiological basis of appetite. In this Review, we discuss advances in neuroscience that have identified brain regions and neural circuits that coordinate distinct phases of eating: food procurement, food consumption, and meal termination. While pioneering work identified several hypothalamic nuclei to be involved in feeding, more recent studies have explored how neuronal populations beyond the hypothalamus, such as the mesolimbic pathway and nodes in the hindbrain, interconnect to modulate appetite. We also examine how long-term exposure to a calorically dense diet rewires feeding circuits and alters the response of motivational systems to food. Understanding how the nervous system regulates eating behaviour will bolster the development of medical strategies that will help individuals to maintain a healthy body weight.
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“The mesolimbic dopamine system is an evolutionarily conserved set of circuits that plays a role in approach and avoidance, appetitive behavior, and reward processing (Wise, 2004; Everitt and Robbins, 2005; Alcantara et al., 2022).”
From Ventral striatum dopamine release encodes unique properties of visual stimuli in mice (2023) · cites this paper as Alcantara et al., 2022
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Sorted by citations
Sequential appetite suppression by oral and visceral feedback to the brainstem
Ly, T., Oh, J. Y., Sivakumar, N., Shehata, S., La Santa Medina, N., Huang, H., Liu, Z., Fang, W., Barnes, C., Dundar, N., et al. (2023) · Nature · doi:10.1038/s41586-023-06758-2 · Cited by 90
GLP-1 and the Neurobiology of Eating Control: Recent Advances
Jones, L. A., & Brierley, D. I. (2025) · Endocrinology · doi:10.1210/endocr/bqae167 · Cited by 43
Ventral striatum dopamine release encodes unique properties of visual stimuli in mice
Gonzalez, L. S., Fisher, A. A., D'Souza, S. P., Cotella, E. M., Lang, R. A., & Robinson, J. E. (2023) · eLife · doi:10.7554/elife.85064 · Cited by 18
“The mesolimbic dopamine system is an evolutionarily conserved set of circuits that plays a role in approach and avoidance, appetitive behavior, and reward processing (Wise, 2004; Everitt and Robbins, 2005; Alcantara et al., 2022).”
BackgroundBehavioral dissection of hunger states in Drosophila
Weaver, K. J., Raju, S., Rucker, R. A., Chakraborty, T., Holt, R. A., & Pletcher, S. D. (2023) · eLife · doi:10.7554/elife.84537.3 · Cited by 13
The Intricate Relationship between Circadian Rhythms and Gastrointestinal Peptides in Obesity
Ribeiro, F. M., Arnaldo, L., P. Milhomem, L., S. Aguiar, S., & Franco, O. L. (2025) · Peptides · doi:10.1016/j.peptides.2025.171356 · Cited by 9
Zalucki, O., Brown, D. J., & Key, B. (2023) · Biology & Philosophy · doi:10.1007/s10539-023-09924-y · Cited by 7
Metadata
- Authors
- Alcantara, I. C., Tapia, A. P. M., Aponte, Y., & Krashes, M. J.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Aponte, Yeka
- Krashes, Michael J.
- Venue
- Nature Metabolism
- Published
- 2022-07-25
- Volume
- 4
- Issue
- 7
- Pages
- 836-847
- ISSN
- 2522-5812 (ISSN-L)
- PMC
- PMC10852214
- OpenAlex
- W4287510211
- Cited by
- 155
- References
- 216
- Citations by year
- 2026: 28 · 2025: 65 · 2024: 29 · 2023: 29 · 2022: 4
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health & Human Services | National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- appetite, feeding circuits, neural circuits, food procurement, dietary intake, meal termination, hypothalamus, mesolimbic system, hindbrain, obesity, eating behaviour, body weight regulation
- MeSH terms
- Appetite, Body Weight, Diet, Feeding Behavior, Humans, Obesity
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