The DOI matches its Crossref record; 171 of the 171 references it cites were found in a registry or an index.
The cGAS–STING pathway and cancer
Open accessAbstract
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has emerged as a critical innate immune pathway that, following engagement by DNA, promotes distinct immune effector responses that can impact virtually all aspects of tumorigenesis, from malignant cell transformation to metastasis. Here we address how natural tumor-associated processes and traditional cancer therapies are shaped by cGAS-STING signaling, and how this contributes to beneficial or detrimental outcomes of cancer. We consider current efforts to target the cGAS-STING axis in tumors and highlight new frontiers in cGAS-STING biology to inspire thinking about their connection to cancer.
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Citations
Cites
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Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
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Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
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The cGAS–STING pathway as a therapeutic target in inflammatory diseases
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Molecular mechanisms and cellular functions of cGAS–STING signalling
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Cited by
Immunotherapy for glioblastoma: current state, challenges, and future perspectives
Liu, Y., Zhou, F., Ali, H., Lathia, J. D., & Chen, P. (2024) · Cellular & Molecular Immunology · doi:10.1038/s41423-024-01226-x · Cited by 336
Regulation of cGAS–STING signalling and its diversity of cellular outcomes
Zhang, Z., & Zhang, C. (2025) · Nature Reviews Immunology · doi:10.1038/s41577-024-01112-7 · Cited by 287
Yu, B., Lu, X., Feng, X., Zhao, T., Li, J., Lu, Y., Ye, F., Liu, X., Zheng, X., Shen, Z., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s428044 · Cited by 23
Metadata
- Authors
- Samson, N., & Ablasser, A.
- Venue
- Nature Cancer
- Published
- 2022-12-12
- Volume
- 3
- Issue
- 12
- Pages
- 1452-1463
- ISSN
- 2662-1347 (ISSN-L)
- OpenAlex
- W4312132334
- Cited by
- 668
- References
- 171
- FWCI
- 37.62
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
