The DOI matches its Crossref record; 226 of the 226 references it cites were found in a registry or an index.
Modelling and targeting mechanical forces in organ fibrosis
Open accessAbstract
Few efficacious therapies exist for the treatment of fibrotic diseases, such as skin scarring, liver cirrhosis and pulmonary fibrosis, which is related to our limited understanding of the fundamental causes and mechanisms of fibrosis. Mechanical forces from cell-matrix interactions, cell-cell contact, fluid flow and other physical stimuli may play a central role in the initiation and propagation of fibrosis. In this Review, we highlight the mechanotransduction mechanisms by which various sources of physical force drive fibrotic disease processes, with an emphasis on central pathways that may be therapeutically targeted to prevent and reverse fibrosis. We then discuss engineered models of mechanotransduction in fibrosis, as well as molecular and biomaterials-based therapeutic approaches for limiting fibrosis and promoting regenerative healing phenotypes in various organs. Finally, we discuss challenges within fibrosis research that remain to be addressed and that may greatly benefit from next-generation bioengineered model systems.
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“A seminal study demonstrated that Cadherin-11 facilitates robust adhesion between M2-like macrophages and myofibroblasts, creating a niche enriched with active TGF-b (3, 57, 63, 64).”
From The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives (2025) · cites this paper as [3]
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Cites
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541
Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy
Neuman, K. C., & Nagy, A. (2008) · Nature Methods · doi:10.1038/nmeth.1218 · Cited by 2,459
Munger, J. S., Huang, X., Kawakatsu, H., Griffiths, M. J. D., Dalton, S. L., Wu, J., Pittet, J.-F., Kaminski, N., Garat, C., Matthay, M. A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80545-0 · Cited by 2,076
Histopathological Image Analysis: A Review
Gurcan, M. N., Boucheron, L. E., Can, A., Madabhushi, A., Rajpoot, N. M., & Yener, B. (2009) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2009.2034865 · Cited by 2,052
Transition from inflammation to proliferation: a critical step during wound healing
Landén, N. X., Li, D., & Ståhle, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2268-0 · Cited by 1,980 · cited 1×
“Within 2 to 10 days, wound repair enters a proliferative phase, characterized by angiogenesis, formation of granulation tissue, and reconstitution of the epithelial barrier by proliferation and migration of keratinocytes at the leading edge 252,253 .”
Fibrotic disease and the TH1/TH2 paradigm
Wynn, T. A. (2004) · Nature Reviews Immunology · doi:10.1038/nri1412 · Cited by 1,765
Formation and function of the myofibroblast during tissue repair
Hinz, B. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700613 · Cited by 1,658
Human organs-on-chips for disease modelling, drug development and personalized medicine
Ingber, D. E. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00466-9 · Cited by 1,589
Deep profiling of mouse splenic architecture with CODEX multiplexed imaging
Goltsev, Y., Samusik, N., Kennedy-Darling, J., Bhate, S., Hale, M., Vazquez, G., Black, S., & Nolan, G. P. (2018) · Cell · doi:10.1016/j.cell.2018.07.010 · Cited by 1,501 · cited 1×
“…can resolve the spatial heterogeneity of fibrosis by quantifying in situ gene and protein expression, which may help to identify cell–cell interactions involved in mechanotransduction signalling and elucidate how localized mechanobiological niches influence profibrotic transcription 185,186 .”
Research works printed but not linked: 2
- Kim, K. K. et al. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J. Clin. Invest. 119, 213–224 (2009).
- Wilder, J. & Patel, K. The clinical utility of FibroScan((R)) as a noninvasive diagnostic test for liver disease. Med. Devices 7, 107–114, (2014).
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de la Lastra, J. M. P., Wardell, S. J. T., Pal, T., de la Fuente‐Núñez, C., & Pletzer, D. (2024) · Journal of Medical Systems · doi:10.1007/s10916-024-02089-5 · Cited by 92
The mechanobiology of fibroblast activation in disease
Chang, Y., Lee, J. W. N., & Holle, A. W. (2025) · APL Bioengineering · doi:10.1063/5.0272393 · Cited by 30
Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets
Long, Y., Wang, P., Lei, J., Su, B., Wei, Q., & Liu, X. (2025) · MedComm · doi:10.1002/mco2.70523 · Cited by 27
Advanced 3D scaffolds for corneal stroma regeneration: a preclinical progress
Salehi, A. O. M., Soleimani, M., Rios, K. S. C., Ortega-Lara, W. D. L., & Mamidi, N. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00090d · Cited by 22
Metadata
- Authors
- Mascharak, S., L. Guo, J., Griffin, M., E. Berry, C., C. Wan, D., & T. Longaker, M.
- Affiliations
- Stanford Medicine (US)
- Venue
- Nature Reviews Bioengineering
- Published
- 2024-01-18
- Volume
- 2
- Issue
- 4
- Pages
- 305-323
- ISSN
- 2731-6092 (ISSN-L)
- PMC
- PMC11567675
- OpenAlex
- W4390964997
- Cited by
- 59
- References
- 226
- Citations by year
- 2026: 33 · 2025: 21 · 2024: 5
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Reviews Bioengineering (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (F32HL167318)
- National Institute of General Medical Sciences (R01GM136659)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR081343)
- National Institute of Dental and Craniofacial Research (R01DE027346, U24DE029463, R01DE032677)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- organ fibrosis, mechanotransduction, mechanical forces, cell-matrix interactions, cell-cell contact, fluid flow, pulmonary fibrosis, liver cirrhosis, scar tissue
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