Tissue mechanics and fibrosis
Open accessAbstract
Mechanical forces are essential to the development and progression of fibrosis, and are likely to be as important as soluble factors. These forces regulate the phenotype and proliferation of myofibroblasts and other cells in damaged tissues, the activation of growth factors, the structure and mechanics of the matrix, and, potentially, tissue patterning. Better understanding of the variety and magnitude of forces, the characteristics of those forces in biological tissues, and their impact on fibrosis in multiple tissues is needed and may lead to identification of important new therapeutic targets. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease.
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GelMA hydrogel stiffness varied from an elastic modulus of 0.1 to 5 kPa, a range consistent with healthy liver tissue to fibrotic liver tissue.
“The change in concentration could alter the stiffness of the GelMA hydrogel, which varied from an elastic modulus of 0.1 to 5 kPa (fig. S3), a range consistent with healthy liver tissue to fibrotic liver tissue (0.1 to 1.8 kPa) (Fig. 2A) (24).”
From Matrix mechanical remodeled carrier-free nanosystem for programmable closed-loop reversal of liver fibrosis via STING alkylation (2025) · cites this paper as [24]
The “Tissue stiffness and stiffness sensing” section supports the general comparison: healthy liver is soft, and fibrotic liver is stiffer. It does not support the cited 0.1–1.8 kPa range for healthy-to-fibrotic liver: it reports 3–22 kPa for fibrotic liver shear modulus and typically greater than 12 kPa for cirrhotic liver elastic modulus. The GelMA measurements are the citing paper’s own results, not a finding attributed to Wells. (LLM, conf=0.86)
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- Authors
- Wells, R. G.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Wells, Rebecca G.
- ORCID
- Wells, Rebecca G.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 1832
- Issue
- 7
- Pages
- 884-890
- ISSN
- 0925-4439 (ISSN-L)
- PMC
- PMC3641165
- OpenAlex
- W2063208689
- Cited by
- 384
- References
- 110
- Citations by year
- 2026: 18 · 2025: 33 · 2024: 42 · 2023: 35 · 2022: 45 · 2021: 54 · 2020: 41 · 2019: 30 · 2018: 33 · 2017: 16 · 2016: 18 · 2015: 12 · 2014: 4 · 2013: 3
- FWCI
- 7.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01-DK-058123)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
- Keywords
- tissue mechanics, fibrosis, mechanical forces, myofibroblasts, myofibroblast proliferation, growth factor activation, tissue patterning, therapeutic target
- MeSH terms
- Fibrosis, Humans, Disease Progression, Myofibroblasts
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