Formation and function of the myofibroblast during tissue repair
Open accessAbstract
It is generally accepted that fibroblast-to-myofibroblast differentiation represents a key event during wound healing and tissue repair. The high contractile force generated by myofibroblasts is beneficial for physiological tissue remodeling but detrimental for tissue function when it becomes excessive such as in hypertrophic scars, in virtually all fibrotic diseases and during stroma reaction to tumors. Specific molecular features as well as factors that control myofibroblast differentiation are potential targets to counteract its development, function, and survival. Such targets include alpha-smooth muscle actin and more recently discovered markers of the myofibroblast cytoskeleton, membrane surface proteins, and the extracellular matrix. Moreover, intervening with myofibroblast stress perception and transmission offers novel strategies to reduce tissue contracture; stress release leads to the instant loss of contraction and promotes apoptosis.
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The transition from fibroblast to myofibroblast includes production of α-smooth muscle actin and its assembly into stress fibres.
“Phenotypic changes occurring in fibroblast-to-myofibroblast transition include the expression of the α-smooth muscle actin (α-SMA) and its incorporation into stress fibres that allows cell's migration and contraction [19,20].”
Starting with the third day after injury, the concentration of hyaluronic acid within the wound area quickly decreases, while collagen takes its place.
“Starting with the third day after the injury, the concentration of hyaluronic acid within the wound area quickly decreases, while collagen takes the place of this glycosaminoglycan.”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [73]
The collagen content in granulation tissue increases up to the third week after the wound appears, accompanied by a gradual decrease of fibroblast amount until they disappear by apoptosis.
“The collagen content in the granulation tissue increases up to the third week, from the moment when the wound appeared, which is accompanied by a gradual decrease of the fibroblast amount up to the moment when they disappear in the process of apoptosis [73].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [73]
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- Authors
- Hinz, B.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Hinz, Boris
- ORCID
- Hinz, Boris
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 127
- Issue
- 3
- Pages
- 526-537
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2013537969
- Cited by
- 1,658
- References
- 150
- Citations by year
- 2026: 86 · 2025: 69 · 2024: 83 · 2023: 86 · 2022: 85 · 2021: 99 · 2020: 92 · 2019: 102 · 2018: 87 · 2017: 92 · 2016: 114 · 2015: 118 · 2014: 101 · 2013: 81 · 2012: 96
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- myofibroblast differentiation, wound healing, tissue repair, tissue remodeling, fibrosis, hypertrophic scars, alpha-smooth muscle actin, extracellular matrix, cytoskeleton, apoptosis, tumor stroma
- MeSH terms
- Actins, Animals, Cell Differentiation, Cell Membrane, Cell Survival, Cells, Cultured, Cytoskeleton, Extracellular Matrix, Fibroblasts, Humans, Models, Biological, Muscles, Wound Healing, Apoptosis, Myocytes, Smooth Muscle
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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