The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer
Open accessAbstract
The carbonic anhydrases (CAs) comprise a family of evolutionarily ancient enzymes found ubiquitously in nature. They have important roles in facilitating transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the unstirred layers of the extracellular space. The tumour-associated isoenzymes, CAIX and CAXII, are expressed in a wide variety of malignancies and appear to be tightly regulated by microenvironmental hypoxia. CAIX expression is linked to poor prognosis in a number of human tumours, and may be a marker of aggressive malignant phenotype and a mechanism of progression. Inhibitors of CA may inhibit tumour growth and invasion, with consequent therapeutic potential.
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Cites
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Carbonic Anhydrase: New Insights for an Ancient Enzyme
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Acidic pH enhances the invasive behavior of human melanoma cells
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Cited by
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH
Švastová, E., Hulı́ková, A., Rafajová, M., Zat'ovičová, M., Gibadulinová, A., Casini, A., Cecchi, A., Scozzafava, A., Supuran, C. T., Pastorek, J., et al. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.10.043 · Cited by 711
Steroid sulfatase: molecular biology, regulation, and inhibition
Reed, M. J., Purohit, A., Woo, L. W. L., Newman, S. P., & Potter, B. V. L. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0003 · Cited by 524
Jensen, R. L. (2009) · Journal of Neuro-Oncology · doi:10.1007/s11060-009-9827-2 · Cited by 287
Metadata
- Authors
- Potter, C. P. S., & Harris, A. L.
- Venue
- British Journal of Cancer
- Published
- 2003-07
- Volume
- 89
- Issue
- 1
- Pages
- 2-7
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2077635615
- Cited by
- 300
- References
- 35
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
