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The carbonic anhydrase domain of receptor tyrosine phosphatase β is a functional ligand for the axonal cell recognition molecule contactin
Open accessAbstract
Receptor-type protein tyrosine phosphatase beta (RPTP beta) is expressed in the developing nervous system and contains a carbonic anhydrase (CAH) domain as well as a fibronectin type III repeat in its extracellular domain. Fusion proteins containing these domains were used to search for ligands of RPTP beta. The CAH domain bound specifically to a 140 kDa protein expressed on the surface of neuronal cells. Expression cloning in COS7 cells revealed that this protein is contactin, a GPI membrane-anchored neuronal cell recognition molecule. The CAH domain of RPTP beta induced cell adhesion and neurite growth of primary tectal neurons, and differentiation of neuroblastoma cells. These responses were blocked by antibodies against contactin, demonstrating that contactin is a neuronal receptor for RPTP beta. These experiments show that an individual domain of RPTP beta acts as a functional ligand for the neuronal receptor contactin. The interaction between contactin and RPTP beta may generate unidirectional or bidirectional signals during neural development.
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Cites
Peles, E., Bacus, S. S., Koski, R. A., Lu, H. S., Wen, D., Ogden, S. G., Levy, R. B., & Yarden, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90131-u · Cited by 524
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Cited by
Structure and mechanism of carbonic anhydrase
Lindskog, S. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(96)00198-2 · Cited by 1,022
Lecticans: organizers of the brain extracellular matrix
Yamaguchi, Y. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000690 · Cited by 642
Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins
Bandtlow, C. E., & Zimmermann, D. R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1267 · Cited by 632
Extracellular matrix of the central nervous system: from neglect to challenge
Zimmermann, D. R., & Dours-Zimmermann, M. T. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0485-9 · Cited by 465
Boyle, M. E. T., Berglund, E. O., Murai, K. K., Weber, L., Peles, E., & Ranscht, B. (2001) · Neuron · doi:10.1016/s0896-6273(01)00296-3 · Cited by 452
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Metadata
- Authors
- Peles, E., Nativ, M., Campbell, P. L., Sakurai, T., Martinez, R., Levt, S., Clary, D. O., Schilling, J., Barnea, G., Plowman, G. D., Grumet, M., & Schlessinger, J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-07
- Volume
- 82
- Issue
- 2
- Pages
- 251-260
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2151915336
- Cited by
- 397
- References
- 1
- FWCI
- 14.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: The carbonic anhydrase domain of receptor tyrosine phosphatase β is a functional ligand for the axonal cell recognition molecule contactin. https://app.cochat.ai/papers/10.1016/0092-8674(95)90312-7
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- Peles, E., Nativ, M., Campbell, P. L., Sakurai, T., Martinez, R., Levt, S., Clary, D. O., Schilling, J., Barnea, G., Plowman, G. D., Grumet, M., & Schlessinger, J. (1995). The carbonic anhydrase domain of receptor tyrosine phosphatase β is a functional ligand for the axonal cell recognition molecule contactin. Cell. https://doi.org/10.1016/0092-8674(95)90312-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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