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Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis

Open access
Clifford, G M, Smith, J S, Aguado, T, Franceschi, S·2003·British Journal of Cancer

Abstract

Particular types of human papillomavirus (HPV) infection may preferentially progress from high-grade squamous intraepithelial lesions (HSIL) to squamous cell carcinoma of the cervix (SCC). We performed a meta-analysis of published data to compare HPV type distribution in HSIL and SCC. HPV16, 18 and 45 were each more prevalent in SCC than HSIL, whereas the reverse was true for other oncogenic types including HPV31, 33, 52 and 58. These data suggest that HSILs infected with HPV16, 18 and 45 preferentially progress to SCC. This may have implications for follow-up protocols of future HPV-based cervical cancer screening programmes and for HPV vaccine trials.

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Metadata

Authors
Clifford, G. M., Smith, J. S., Aguado, T., & Franceschi, S.
Venue
British Journal of Cancer
Published
2003-07
Volume
89
Issue
1
Pages
101-105
ISSN
  • 0007-0920 (ISSN-L)
  • 1532-1827
OpenAlex
W2066860562
Cited by
684
References
0
FWCI
20.63
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis. https://app.cochat.ai/papers/10.1038/sj.bjc.6601024
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Clifford, G. M., Smith, J. S., Aguado, T., & Franceschi, S. (2003). Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis. British Journal of Cancer. https://doi.org/10.1038/sj.bjc.6601024

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.