The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration
Open accessAbstract
Studies in vitro and in animal models of colorectal and hepatocellular cancers suggest that curcumin is an effective chemopreventive agent. In this pilot trial, we investigated whether oral administration of curcumin results in concentrations of the agent in normal and malignant human liver tissue, which are sufficient to elicit pharmacological activity. In total, 12 patients with hepatic metastases from colorectal cancer received 450-3600 mg of curcumin daily, for 1 week prior to surgery. Levels of curcumin and its metabolites were measured by HPLC in portal and peripheral blood, bile and liver tissue. Curcumin was poorly available, following oral administration, with low nanomolar levels of the parent compound and its glucuronide and sulphate conjugates found in the peripheral or portal circulation. While curcumin was not found in liver tissue, trace levels of products of its metabolic reduction were detected. In patients who had received curcumin, levels of malondialdehyde-DNA (M(1)G) adduct, which reflect oxidative DNA changes, were not decreased in post-treatment normal and malignant liver tissue when compared to pretreatment samples. The results suggest that doses of curcumin required to furnish hepatic levels sufficient to exert pharmacological activity are probably not feasible in humans.
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Colletti, L. M., Remick, D. G., Burtch, G. D., Kunkel, S. L., Strieter, R. M., & Campbell, D. A. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114656 · Cited by 817 · cited 1×
“Consequently, Kupffer cells are activated, resulting in the production of reactive oxygen species and cytokines, thus precipitating oxidative stress (Colletti et al, 1990; Wang et al, 1994).”
Background
Cited by
Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543
CURCUMIN: THE INDIAN SOLID GOLD
Aggarwal, B. B., Sundaram, C., Malani, N., & Ichikawa, H. (2007) · ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY · doi:10.1007/978-0-387-46401-5_1 · Cited by 1,647
Aggarwal, B. B., & Sung, B. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.11.002 · Cited by 1,140
Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment
Basnet, P., & Skalko-Basnet, N. (2011) · Molecules · doi:10.3390/molecules16064567 · Cited by 733
Lee, W.-H., Loo, C.-Y., Bebawy, M., Luk, F., Mason, R., & Rohanizadeh, R. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311040002 · Cited by 537
Metadata
- Authors
- Garcea, G., Jones, D. J. L., Singh, R., Dennison, A. R., Farmer, P. B., Sharma, R. A., Steward, W. P., Gescher, A. J., & Berry, D. P.
- Venue
- British Journal of Cancer
- Published
- 2004-03
- Volume
- 90
- Issue
- 5
- Pages
- 1011-1015
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2077008353
- Cited by
- 425
- References
- 1
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Garcea, G., Jones, D. J. L., Singh, R., Dennison, A. R., Farmer, P. B., Sharma, R. A., Steward, W. P., Gescher, A. J., & Berry, D. P. (2004). Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration. British Journal of Cancer. https://doi.org/10.1038/sj.bjc.6601623
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