The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment
Open accessAbstract
Oxidative damage and inflammation have been pointed out in preclinical studies as the root cause of cancer and other chronic diseases such as diabetes, hypertension, Alzheimer’s disease, etc. Epidemiological and clinical studies have suggested that cancer could be prevented or significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore, curcumin, a principal component of turmeric (a curry spice) showing strong anti-oxidant and anti-inflammatory activities, might be a potential candidate for the prevention and/or treatment of cancer and other chronic diseases. However, curcumin, a highly pleiotropic molecule with an excellent safety profile targeting multiple diseases with strong evidence on the molecular level, could not achieve its optimum therapeutic outcome in past clinical trials, largely due to its low solubility and poor bioavailability. Curcumin can be developed as a therapeutic drug through improvement in formulation properties or delivery systems, enabling its enhanced absorption and cellular uptake. This review mainly focuses on the anti-inflammatory potential of curcumin and recent developments in dosage form and nanoparticulate delivery systems with the possibilities of therapeutic application of curcumin for the prevention and/or treatment of cancer.
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Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
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Modes of resistance to anti-angiogenic therapy
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“This concept is exemplified by recent discoveries [165-167].”
BackgroundThe role of cyclooxygenases in inflammation, cancer, and development
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Cited by
Curcumin: A Review of Its Effects on Human Health
Hewlings, S., & Kalman, D. (2017) · Foods · doi:10.3390/foods6100092 · Cited by 2,720
Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study
Lopresti, A. L., Maes, M., Maker, G. L., Hood, S. D., & Drummond, P. D. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.06.001 · Cited by 216
Long, Y., Zhang, W., Wang, F., & Chen, Z. (2014) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2013.10.002 · Cited by 53
Research Mechanism and Progress of the Natural Compound Curcumin in Treating Alzheimer’s Disease
Li, L., Wang, F., Jia, X., Yao, L., & Liu, Y. (2024) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575263783231009051957 · Cited by 11
Effect of turmeric extract on bone healing in an experimental model of femoral bone fracture
Ilka (2022) · PubMed · doi:10.22038/ajp.2021.18561 · Cited by 7
Metadata
- Authors
- Basnet, P., & Skalko-Basnet, N.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2011-06-03
- Volume
- 16
- Issue
- 6
- Pages
- 4567-4598
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2102192655
- Cited by
- 733
- References
- 5
- FWCI
- 16.30
- Type
- journal article
- Language
- en
- Open access
- gold
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