The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects
Open accessAbstract
Dendritic and lymphoid 'exosomes' regulate immune activation. Tumours release membranous material mimicking these 'exosomes,' resulting in deletion of reactive lymphocytes. Tumour-derived 'exosomes' have recently been explored as vaccines, without analysis of their immunologic consequences. This investigation examines the composition of tumour-derived 'exosomes' and their effects on T lymphocytes. Membranous materials were isolated from ascites of ovarian cancer patients (n=6) and Western immunoblotting was performed for markers associated with 'exosomes.' Using cultured T cells, 'exosomes' were evaluated for suppression of CD3-zeta and JAK 3 expressions and induction of apoptosis, measured by DNA fragmentation. 'Exosome' components mediating suppression of CD3-zeta were isolated by continuous eluting electrophoresis and examined by Western immunoblotting. 'Exosomes' were shown to be identical with previously characterised shed membrane vesicles by protein staining and TSG101 expression. 'Exosomes' expressed class I MHC, placental alkaline phosphatase, B23/nucleophosmin, and FasL. 'Exosomes' suppressed expression of T-cell activation signalling components, CD3-zeta and JAK 3 and induced apoptosis. CD3-zeta suppression was mediated by two components: 26 and 42 kDa. Only the 42 kDa component reacted with anti-FasL antibody. These results indicate that, while 'exosomes' express tumour antigens, leading to their proposed utility as tumour vaccines, they also can suppress T-cell signalling molecules and induce apoptosis.
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Cited by
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
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Microfluidic isolation and transcriptome analysis of serum microvesicles
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Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production
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Metadata
- Authors
- Taylor, D. D., & Gerçel-Taylor, C.
- Venue
- British Journal of Cancer
- Published
- 2005-01
- Volume
- 92
- Issue
- 2
- Pages
- 305-311
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2058297649
- Cited by
- 391
- References
- 37
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
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