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Differential disruption of cell cycle pathways in small cell and non-small cell lung cancer
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The 88 genes differentially expressed in both cohorts included known EGFRMUT-associated genes ETV5 and NKX2-1.
“The 88 genes showed clear differential expression across EGFRMUT and EGFRWT tumors and contained known EGFRMUT associated genes such as ETV5 and NKX2-118, 19.”
From Integrative Genomic Analyses Identifies GGA2 as a Cooperative Driver of EGFR-Mediated Lung Tumorigenesis (2019) · cites this paper as [19]
The Results and Discussion section identifies 159 genes differentially expressed between small-cell and non-small-cell lung cancer cell lines, not genes associated with EGFR mutation status. Searches for ETV5, NKX2-1, and EGFR-mutant versus wild-type tumors found no passage establishing the association attributed to this source; the citing paper’s 88-gene result is not something this source can verify. (LLM, conf=0.75)
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Cites
Mitogen-activated protein kinases in apoptosis regulation
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BackgroundBlockade of RAGE-amphoterin signalling suppresses tumour growth and metastases
Taguchi, A., Blood, D. C., del Toro, G., Canet, A., Lee, D. C., Qu, W., Tanji, N., Lu, Y., Lalla, E., Fu, C., et al. (2000) · Nature · doi:10.1038/35012626 · Cited by 1,217
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
Bracken, A. P., Pasini, D., Capra, M., Prosperini, E., Colli, E., & Helin, K. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg542 · Cited by 1,196
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O’Farrell, H., Harbourne, B., Kurlawala, Z., Inoue, Y., Nagelberg, A. L., Martinez, V. D., Lu, D., Oh, M. H., Coe, B. P., Thu, K. L., et al. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2018.12.004 · Cited by 23
Self-citation
Metadata
- Authors
- Coe, B. P., Lockwood, W. W., Girard, L., Chari, R., MacAulay, C., Lam, S., Gazdar, A. F., Minna, J. D., & Lam, W. L.
- Venue
- British Journal of Cancer
- Published
- 2006-05-16
- Volume
- 94
- Issue
- 12
- Pages
- 1927-1935
- ISSN
- 0007-0920
- 1532-1827
- PMC
- PMC2361340
- Cited by
- 67
- References
- 4
- Language
- en
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