The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Telomere and telomerase in stem cells
Open accessAbstract
Telomeres, guanine-rich tandem DNA repeats of the chromosomal end, provide chromosomal stability, and cellular replication causes their loss. In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. In embryonic stem cells, telomerase is activated and maintains telomere length and cellular immortality; however, the level of telomerase activity is low or absent in the majority of stem cells regardless of their proliferative capacity. Thus, even in stem cells, except for embryonal stem cells and cancer stem cells, telomere shortening occurs during replicative ageing, possibly at a slower rate than that in normal somatic cells. Recently, the importance of telomere maintenance in human stem cells has been highlighted by studies on dyskeratosis congenital, which is a genetic disorder in the human telomerase component. The regulation of telomere length and telomerase activity is a complex and dynamic process that is tightly linked to cell cycle regulation in human stem cells. Here we review the role of telomeres and telomerase in the function and capacity of the human stem cells.
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“TELOMERES AND TELOMERASE IN HEMATOPOIETIC STEM CELLS In the hematopoietic system, telomerase-expressing cells are stem cells with self-renewal potential and their early descendants (Hiyama et al., 1995; Morrison et al., 1996).”
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Cited by
Killela, P. J., Reitman, Z. J., Jiao, Y., Bettegowda, C., Agrawal, N., Diaz, L. A., Friedman, A. H., Friedman, H., Gallia, G. L., Giovanella, B. C., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303607110 · Cited by 1,368
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Targeting telomeres and telomerase
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Soft fibrin gels promote selection and growth of tumorigenic cells
Liu, J., Tan, Y., Zhang, H., Zhang, Y., Xu, P., Chen, J., Poh, Y.-C., Tang, K., Wang, N., & Huang, B. (2012) · Nature Materials · doi:10.1038/nmat3361 · Cited by 468
Defining stem and progenitor cells within adipose tissue
Lin, G., Garcia, M., Ning, H., Banie, L., Guo, Y.-L., Lue, T. F., & Lin, C.-S. (2008) · Stem Cells and Development · doi:10.1089/scd.2008.0117 · Cited by 398
Metadata
- Authors
- Hiyama, E., & Hiyama, K.
- Venue
- British Journal of Cancer
- Published
- 2007-03-13
- Volume
- 96
- Issue
- 7
- Pages
- 1020-1024
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2163229747
- Cited by
- 548
- References
- 48
- FWCI
- 14.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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