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Telomeres and human disease: ageing, cancer and beyond

Blasco, Maria A.·2005·Nature Reviews Genetics
DOI 10.1038/nrg1656
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Abstract

Telomere length and telomerase activity are important factors in the pathobiology of human disease. Age-related diseases and premature ageing syndromes are characterized by short telomeres, which can compromise cell viability, whereas tumour cells can prevent telomere loss by aberrantly upregulating telomerase. Altered functioning of both telomerase and telomere-interacting proteins is present in some human premature ageing syndromes and in cancer, and recent findings indicate that alterations that affect telomeres at the level of chromatin structure might also have a role in human disease. These findings have inspired a number of potential therapeutic strategies that are based on telomerase and telomeres.

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  • Telomerase prevents the deleterious effects of telomere shortening by elongating telomeres to maintain their adequate length.

    “These deleterious effects can be prevented by the reverse transcriptase activity of telomerase, an active ribonucleoprotein that elongates telomeres to maintain their adequate length 31,32 .”

    From Hallmarks of aging: An expanding universe (2023) · cites this paper as [32]

  • Senescence is triggered at least in part by telomere shortening with aging.

    “a process that is triggered at least in part by telomere shortening with aging 32 .”

    From Hallmarks of aging: An expanding universe (2023) · cites this paper as [32]

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Metadata

Authors
Blasco, M. A.
Venue
Nature Reviews Genetics
Publisher
Springer Science and Business Media LLC
Published
2005-08
Volume
6
Issue
8
Pages
611-622
ISSN
  • 1471-0056
  • 1471-0064
DOI
10.1038/nrg1656
Cited by
1,434
References
30
Language
en
Licence
www.springer.com/tdm (tdm)

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